Matches in SemOpenAlex for { <https://semopenalex.org/work/W2401808577> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2401808577 endingPage "5" @default.
- W2401808577 startingPage "1910" @default.
- W2401808577 abstract "The distribution of radioactivity in the rat brain at 5 min after 10 mg/kg of 14C-labelled N-methyl-2[(o-methyl-a-phenylbenzyl)oxy]ethylamine, [14C]-tofenacine-hydrochloride, the active constituent of Elamol¿ and Tofacine¿, i.v. showed a heterogeneous pattern correlating well with what is known about perfusion and capillarization of brain areas. With the passage of time total brain radioactivity decreased rapidly and radioactivity was redistributed. Both processes occurred simultaneously so that a nearly homogeneous pattern was found at 1 h after i.v. administration. The outer layers of the hippocampus were then the only brain areas with a higher concentration of radioactivity. On i.p. administration of 25 mg/kg of [14C]-tofenacine-hydrochloride maximum brain radioactivity was observed at 30 min, the distribution pattern resembling that seen at 5 min after i.v. dosage. Its further time course corresponded to that of the i.v. series. On multiple oral administration of [14C]-tofenacine-hydrochloride (4 doses of 25 mg/kg at 3-h intervals), maximal radioactivity in the rat brain was observed at 120 min after the last dose. Again the distribution was heterogeneous. Areas of high and low radioactivity were very similar to those seen in the i.v. series at the first intervals, although the contrasts were less pronounced. An exception was the hippocampus where the distribution of radioactivity, -- with high levels in the outer layers as the principal feature -- was similar to that at the last intervals after i.v. administration. A model comprising a central compartment and two brain compartments, representing areas of high and low perfusion, respectively, allows a quantitative explanation of the phenomena observed." @default.
- W2401808577 created "2016-06-24" @default.
- W2401808577 creator A5013119521 @default.
- W2401808577 creator A5051176427 @default.
- W2401808577 date "1975-01-01" @default.
- W2401808577 modified "2023-09-23" @default.
- W2401808577 title "Distribution of [14C]-tofenacine in rat brain after intravenous, intraperitoneal and multiple oral dosage." @default.
- W2401808577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1243662" @default.
- W2401808577 hasPublicationYear "1975" @default.
- W2401808577 type Work @default.
- W2401808577 sameAs 2401808577 @default.
- W2401808577 citedByCount "0" @default.
- W2401808577 crossrefType "journal-article" @default.
- W2401808577 hasAuthorship W2401808577A5013119521 @default.
- W2401808577 hasAuthorship W2401808577A5051176427 @default.
- W2401808577 hasConcept C110121322 @default.
- W2401808577 hasConcept C121332964 @default.
- W2401808577 hasConcept C126322002 @default.
- W2401808577 hasConcept C134306372 @default.
- W2401808577 hasConcept C185592680 @default.
- W2401808577 hasConcept C2776460385 @default.
- W2401808577 hasConcept C2777056448 @default.
- W2401808577 hasConcept C2781161787 @default.
- W2401808577 hasConcept C33923547 @default.
- W2401808577 hasConcept C55493867 @default.
- W2401808577 hasConcept C66882249 @default.
- W2401808577 hasConcept C71924100 @default.
- W2401808577 hasConcept C86803240 @default.
- W2401808577 hasConcept C97355855 @default.
- W2401808577 hasConcept C98274493 @default.
- W2401808577 hasConceptScore W2401808577C110121322 @default.
- W2401808577 hasConceptScore W2401808577C121332964 @default.
- W2401808577 hasConceptScore W2401808577C126322002 @default.
- W2401808577 hasConceptScore W2401808577C134306372 @default.
- W2401808577 hasConceptScore W2401808577C185592680 @default.
- W2401808577 hasConceptScore W2401808577C2776460385 @default.
- W2401808577 hasConceptScore W2401808577C2777056448 @default.
- W2401808577 hasConceptScore W2401808577C2781161787 @default.
- W2401808577 hasConceptScore W2401808577C33923547 @default.
- W2401808577 hasConceptScore W2401808577C55493867 @default.
- W2401808577 hasConceptScore W2401808577C66882249 @default.
- W2401808577 hasConceptScore W2401808577C71924100 @default.
- W2401808577 hasConceptScore W2401808577C86803240 @default.
- W2401808577 hasConceptScore W2401808577C97355855 @default.
- W2401808577 hasConceptScore W2401808577C98274493 @default.
- W2401808577 hasIssue "12" @default.
- W2401808577 hasLocation W24018085771 @default.
- W2401808577 hasOpenAccess W2401808577 @default.
- W2401808577 hasPrimaryLocation W24018085771 @default.
- W2401808577 hasRelatedWork W1999146294 @default.
- W2401808577 hasRelatedWork W2021551397 @default.
- W2401808577 hasRelatedWork W2103126842 @default.
- W2401808577 hasRelatedWork W2117501861 @default.
- W2401808577 hasRelatedWork W2142238400 @default.
- W2401808577 hasRelatedWork W2315719950 @default.
- W2401808577 hasRelatedWork W2406588624 @default.
- W2401808577 hasRelatedWork W2409040035 @default.
- W2401808577 hasRelatedWork W2411423086 @default.
- W2401808577 hasRelatedWork W3120625362 @default.
- W2401808577 hasVolume "25" @default.
- W2401808577 isParatext "false" @default.
- W2401808577 isRetracted "false" @default.
- W2401808577 magId "2401808577" @default.
- W2401808577 workType "article" @default.