FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2401839542> ?p ?o ?g. }

• W2401839542 endingPage "1047" @default.
• W2401839542 startingPage "1040" @default.
• W2401839542 abstract "Alzheimer’s disease (AD), the most common cause of dementia in the elderly, is characterized by deficits in cognition and memory. Although amyloid-β (Aβ) accumulation is known to be the earliest pathological event that triggers subsequent neurodegeneration, how Aβ accumulation causes behavioral deficits remains incompletely understood. In this study, using the Morris water maze test, ELISA and stereological methods, we examined spatial learning and memory performance, the soluble Aβ concentration and the myelination of fibers in the hippocampus of 4-, 6-, 8- and 10-month-old Tg2576 AD model mice. Our results showed that spatial learning and memory performance was significantly impaired in the Tg2576 mice compared to the wild type (WT) controls and that the myelinated fiber length in the hippocampal dentate gyrus (DG) was markedly decreased from 0.33 ± 0.03 km in the WT controls to 0.17 ± 0.02 km in the Tg2576 mice at 10 months of age. However, the concentrations of soluble Aβ40 and Aβ42 were significantly increased as early as 4-6 months of age. The decreased myelinated fiber length in the DG may contribute to the spatial learning and memory deficits of Tg2576 mice. Therefore, we suggest that the significant accumulation of soluble Aβ may serve as a preclinical biomarker for AD diagnosis and that protecting myelinated fibers may represent a novel strategy for delaying the progression of early-stage AD. Keywords: Alzheimer’s disease, Aβ, hippocampus, myelinated fiber, stereology, Tg2576 mouse." @default.
• W2401839542 created "2016-06-24" @default.
• W2401839542 creator A5001864357 @default.
• W2401839542 creator A5019200264 @default.
• W2401839542 creator A5020020050 @default.
• W2401839542 creator A5032269876 @default.
• W2401839542 creator A5050475802 @default.
• W2401839542 creator A5060141911 @default.
• W2401839542 creator A5070811798 @default.
• W2401839542 creator A5075546277 @default.
• W2401839542 creator A5078143614 @default.
• W2401839542 creator A5082185821 @default.
• W2401839542 date "2016-07-20" @default.
• W2401839542 modified "2023-10-16" @default.
• W2401839542 title "Decreased Myelinated Fibers in the Hippocampal Dentate Gyrus of the Tg2576 Mouse Model of Alzheimer's Disease" @default.
• W2401839542 cites W127741752 @default.
• W2401839542 cites W1572812739 @default.
• W2401839542 cites W1963097925 @default.
• W2401839542 cites W1963620452 @default.
• W2401839542 cites W1972573416 @default.
• W2401839542 cites W1992484817 @default.
• W2401839542 cites W1995809230 @default.
• W2401839542 cites W2000706612 @default.
• W2401839542 cites W2001210466 @default.
• W2401839542 cites W2001327864 @default.
• W2401839542 cites W2004546493 @default.
• W2401839542 cites W2007922488 @default.
• W2401839542 cites W2009832268 @default.
• W2401839542 cites W2011719655 @default.
• W2401839542 cites W2015669295 @default.
• W2401839542 cites W2027821802 @default.
• W2401839542 cites W2042419130 @default.
• W2401839542 cites W2048251539 @default.
• W2401839542 cites W2056657762 @default.
• W2401839542 cites W2059696821 @default.
• W2401839542 cites W2072704019 @default.
• W2401839542 cites W2079206376 @default.
• W2401839542 cites W2082429191 @default.
• W2401839542 cites W2084015594 @default.
• W2401839542 cites W2088151512 @default.
• W2401839542 cites W2096410114 @default.
• W2401839542 cites W2103440561 @default.
• W2401839542 cites W2104757313 @default.
• W2401839542 cites W2107960095 @default.
• W2401839542 cites W2110000213 @default.
• W2401839542 cites W2116155138 @default.
• W2401839542 cites W2118671543 @default.
• W2401839542 cites W2136901555 @default.
• W2401839542 cites W2139671539 @default.
• W2401839542 cites W2151137844 @default.
• W2401839542 doi "https://doi.org/10.2174/1567205013666160314150709" @default.
• W2401839542 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5002931" @default.
• W2401839542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26971933" @default.
• W2401839542 hasPublicationYear "2016" @default.
• W2401839542 type Work @default.
• W2401839542 sameAs 2401839542 @default.
• W2401839542 citedByCount "9" @default.
• W2401839542 countsByYear W24018395422017 @default.
• W2401839542 countsByYear W24018395422018 @default.
• W2401839542 countsByYear W24018395422020 @default.
• W2401839542 countsByYear W24018395422021 @default.
• W2401839542 countsByYear W24018395422022 @default.
• W2401839542 countsByYear W24018395422023 @default.
• W2401839542 crossrefType "journal-article" @default.
• W2401839542 hasAuthorship W2401839542A5001864357 @default.
• W2401839542 hasAuthorship W2401839542A5019200264 @default.
• W2401839542 hasAuthorship W2401839542A5020020050 @default.
• W2401839542 hasAuthorship W2401839542A5032269876 @default.
• W2401839542 hasAuthorship W2401839542A5050475802 @default.
• W2401839542 hasAuthorship W2401839542A5060141911 @default.
• W2401839542 hasAuthorship W2401839542A5070811798 @default.
• W2401839542 hasAuthorship W2401839542A5075546277 @default.
• W2401839542 hasAuthorship W2401839542A5078143614 @default.
• W2401839542 hasAuthorship W2401839542A5082185821 @default.
• W2401839542 hasBestOaLocation W24018395422 @default.
• W2401839542 hasConcept C126322002 @default.
• W2401839542 hasConcept C134018914 @default.
• W2401839542 hasConcept C142724271 @default.
• W2401839542 hasConcept C148762608 @default.
• W2401839542 hasConcept C15744967 @default.
• W2401839542 hasConcept C169760540 @default.
• W2401839542 hasConcept C2776464000 @default.
• W2401839542 hasConcept C2776925932 @default.
• W2401839542 hasConcept C2776993930 @default.
• W2401839542 hasConcept C2779134260 @default.
• W2401839542 hasConcept C2781161787 @default.
• W2401839542 hasConcept C44752575 @default.
• W2401839542 hasConcept C502032728 @default.
• W2401839542 hasConcept C71924100 @default.
• W2401839542 hasConceptScore W2401839542C126322002 @default.
• W2401839542 hasConceptScore W2401839542C134018914 @default.
• W2401839542 hasConceptScore W2401839542C142724271 @default.
• W2401839542 hasConceptScore W2401839542C148762608 @default.
• W2401839542 hasConceptScore W2401839542C15744967 @default.
• W2401839542 hasConceptScore W2401839542C169760540 @default.
• W2401839542 hasConceptScore W2401839542C2776464000 @default.
• W2401839542 hasConceptScore W2401839542C2776925932 @default.
• W2401839542 hasConceptScore W2401839542C2776993930 @default.

• next