Matches in SemOpenAlex for { <https://semopenalex.org/work/W240188654> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W240188654 endingPage "67.13" @default.
- W240188654 startingPage "67.13" @default.
- W240188654 abstract "Abstract T cell cross-reactivity describes the phenomenon whereby a single T cell can recognize two or more different peptide antigens presented in complex withMHCproteins. Cross-reactive T cells have previously been characterized at the population level by cytokine secretion and MHC tetramer staining assays, but single-cell analysis is difficult or impossible using these methods. In this study, we describe development of a novel peptide-MHC heterodimer specific for cross-reactive T cells. MHC-peptide monomers were independently conjugated to hydrazide or aldehyde-containing cross-linkers using thiol-maleimide coupling at cysteine residues introduced into recombinant MHC heavy chain proteins. Hydrazone formation provided bi-specific MHC heterodimers carrying two different peptides. Using this approach we prepared heterodimers of the murine class I MHC protein H-2Kb carrying peptides from lymphocytic choriomeningitis virus and vaccinia virus, and used these to identify crossreactive CD8[|#1#|] T cells recognizing both lymphocytic choriomeningitis virus and vaccinia virus antigens. A similar strategy could be used to develop reagents to analyze cross-reactive T cell responses in humans." @default.
- W240188654 created "2016-06-24" @default.
- W240188654 creator A5007129617 @default.
- W240188654 creator A5016467167 @default.
- W240188654 creator A5023032912 @default.
- W240188654 creator A5033703557 @default.
- W240188654 creator A5034784009 @default.
- W240188654 creator A5054495834 @default.
- W240188654 creator A5091676156 @default.
- W240188654 date "2011-04-01" @default.
- W240188654 modified "2023-10-01" @default.
- W240188654 title "Bi-specific MHC heterodimers for the characterization of cross-reactive T cells (67.13)" @default.
- W240188654 doi "https://doi.org/10.4049/jimmunol.186.supp.67.13" @default.
- W240188654 hasPublicationYear "2011" @default.
- W240188654 type Work @default.
- W240188654 sameAs 240188654 @default.
- W240188654 citedByCount "0" @default.
- W240188654 crossrefType "journal-article" @default.
- W240188654 hasAuthorship W240188654A5007129617 @default.
- W240188654 hasAuthorship W240188654A5016467167 @default.
- W240188654 hasAuthorship W240188654A5023032912 @default.
- W240188654 hasAuthorship W240188654A5033703557 @default.
- W240188654 hasAuthorship W240188654A5034784009 @default.
- W240188654 hasAuthorship W240188654A5054495834 @default.
- W240188654 hasAuthorship W240188654A5091676156 @default.
- W240188654 hasConcept C147483822 @default.
- W240188654 hasConcept C153911025 @default.
- W240188654 hasConcept C154317977 @default.
- W240188654 hasConcept C159047783 @default.
- W240188654 hasConcept C167672396 @default.
- W240188654 hasConcept C170627219 @default.
- W240188654 hasConcept C185592680 @default.
- W240188654 hasConcept C197695756 @default.
- W240188654 hasConcept C202751555 @default.
- W240188654 hasConcept C203014093 @default.
- W240188654 hasConcept C207936829 @default.
- W240188654 hasConcept C2776090121 @default.
- W240188654 hasConcept C2780190958 @default.
- W240188654 hasConcept C55493867 @default.
- W240188654 hasConcept C67662055 @default.
- W240188654 hasConcept C86803240 @default.
- W240188654 hasConcept C8840205 @default.
- W240188654 hasConcept C8891405 @default.
- W240188654 hasConceptScore W240188654C147483822 @default.
- W240188654 hasConceptScore W240188654C153911025 @default.
- W240188654 hasConceptScore W240188654C154317977 @default.
- W240188654 hasConceptScore W240188654C159047783 @default.
- W240188654 hasConceptScore W240188654C167672396 @default.
- W240188654 hasConceptScore W240188654C170627219 @default.
- W240188654 hasConceptScore W240188654C185592680 @default.
- W240188654 hasConceptScore W240188654C197695756 @default.
- W240188654 hasConceptScore W240188654C202751555 @default.
- W240188654 hasConceptScore W240188654C203014093 @default.
- W240188654 hasConceptScore W240188654C207936829 @default.
- W240188654 hasConceptScore W240188654C2776090121 @default.
- W240188654 hasConceptScore W240188654C2780190958 @default.
- W240188654 hasConceptScore W240188654C55493867 @default.
- W240188654 hasConceptScore W240188654C67662055 @default.
- W240188654 hasConceptScore W240188654C86803240 @default.
- W240188654 hasConceptScore W240188654C8840205 @default.
- W240188654 hasConceptScore W240188654C8891405 @default.
- W240188654 hasIssue "1_Supplement" @default.
- W240188654 hasLocation W2401886541 @default.
- W240188654 hasOpenAccess W240188654 @default.
- W240188654 hasPrimaryLocation W2401886541 @default.
- W240188654 hasRelatedWork W1578871315 @default.
- W240188654 hasRelatedWork W1968611188 @default.
- W240188654 hasRelatedWork W2004201339 @default.
- W240188654 hasRelatedWork W2038503104 @default.
- W240188654 hasRelatedWork W2048022893 @default.
- W240188654 hasRelatedWork W2087244840 @default.
- W240188654 hasRelatedWork W2092970886 @default.
- W240188654 hasRelatedWork W2287738525 @default.
- W240188654 hasRelatedWork W2401616340 @default.
- W240188654 hasRelatedWork W53613737 @default.
- W240188654 hasVolume "186" @default.
- W240188654 isParatext "false" @default.
- W240188654 isRetracted "false" @default.
- W240188654 magId "240188654" @default.
- W240188654 workType "article" @default.