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- W2401919958 abstract "The presence of mutated Ras in more that 30% of human cancers has spurred interest in the identification of molecules that can block its uncontrolled signaling function. A particular focus in recent years has been a key posttranslational modification of Ras that places a farnesyl group on a cysteine residue near the C-terminus of the protein. In this chapter we describe recent progress in the design of inhibitors for the enzyme that catalyzes this step, protein farnesyltransferase, and show their potential for blocking oncogenic cell growth." @default.
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- W2401919958 date "2003-01-01" @default.
- W2401919958 modified "2023-09-23" @default.
- W2401919958 title "The development of protein farnesyltransferase inhibitors as signaling-based anticancer agents." @default.
- W2401919958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14593715" @default.
- W2401919958 hasPublicationYear "2003" @default.
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