FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2401931799> ?p ?o ?g. }

• W2401931799 endingPage "296" @default.
• W2401931799 startingPage "286" @default.
• W2401931799 abstract "Although genetic alterations in patients with advanced gastric cancer have been extensively studied, those in patients with intramucosal neoplasia (IMN) are still poorly understood.We evaluated genetic differences in 158 IMNs, including 51 low-grade dysplasias, 58 high-grade dysplasias (HGDs), 30 intramucosal cancers (IMCs), and 19 mixed tumors (composed of IMC and HGD within the same tumor), using PCR-based microsatellite analysis [allelic imbalance (AI) and microsatellite instability (MSI)]. We classified the DNA methylation status as a hypermethylated epigenome, a moderately methylated epigenome, or a hypomethylated epigenome. In addition, p53 overexpression, β-catenin nuclear localization, and mucin expression were also examined.From cluster analysis, the IMNs examined were categorized into four subgroups as follows. Tumors in subgroup 1 were characterized by MSI-high status, a hypermethylated epigenome, and loss or reduction of expression of MLH-1. Tumors in subgroup 2 showed a mixed pattern consisting of AI and MSI. In contrast, tumors in subgroup 3, which showed accumulation of multiple AIs, were closely associated with HGD, IMC, or mixed tumor and exhibited nuclear expression of β-catenin. Tumors in subgroup 4, which were generally low-grade dysplasias, exhibited a low frequency of AIs and no MSI. Although the mucin phenotype was not correlated with any subgroup, expression of mucin was associated with some subgroups. Overexpression of p53 was common in all subgroups.The approach described herein was useful for studying genetic differences in IMNs. In addition, we suggest that stratification of genetic differences may help to identify genetic molecular profiles in IMNs." @default.
• W2401931799 created "2016-06-24" @default.
• W2401931799 creator A5008740185 @default.
• W2401931799 creator A5012441260 @default.
• W2401931799 creator A5015183700 @default.
• W2401931799 creator A5049246136 @default.
• W2401931799 creator A5059967888 @default.
• W2401931799 creator A5064856279 @default.
• W2401931799 creator A5072372977 @default.
• W2401931799 creator A5085844474 @default.
• W2401931799 creator A5088527994 @default.
• W2401931799 creator A5090669318 @default.
• W2401931799 creator A5091341412 @default.
• W2401931799 date "2016-05-28" @default.
• W2401931799 modified "2023-10-18" @default.
• W2401931799 title "Genetic differences stratified by PCR-based microsatellite analysis in gastric intramucosal neoplasia" @default.
• W2401931799 cites W141799699 @default.
• W2401931799 cites W1544851750 @default.
• W2401931799 cites W1922816213 @default.
• W2401931799 cites W2014064969 @default.
• W2401931799 cites W2016799106 @default.
• W2401931799 cites W2024675705 @default.
• W2401931799 cites W2025605313 @default.
• W2401931799 cites W2026049398 @default.
• W2401931799 cites W2035621887 @default.
• W2401931799 cites W2044918191 @default.
• W2401931799 cites W2052137476 @default.
• W2401931799 cites W2060423329 @default.
• W2401931799 cites W2065499545 @default.
• W2401931799 cites W2068799997 @default.
• W2401931799 cites W2075407747 @default.
• W2401931799 cites W2084393590 @default.
• W2401931799 cites W2088803053 @default.
• W2401931799 cites W2094018565 @default.
• W2401931799 cites W2096328220 @default.
• W2401931799 cites W2097795604 @default.
• W2401931799 cites W2126547130 @default.
• W2401931799 cites W2128146359 @default.
• W2401931799 cites W2132327532 @default.
• W2401931799 cites W2134335199 @default.
• W2401931799 cites W2134762300 @default.
• W2401931799 cites W2154546296 @default.
• W2401931799 cites W2155088820 @default.
• W2401931799 cites W2156080185 @default.
• W2401931799 cites W2168880061 @default.
• W2401931799 cites W2266320833 @default.
• W2401931799 cites W2327002136 @default.
• W2401931799 cites W4231021828 @default.
• W2401931799 doi "https://doi.org/10.1007/s10120-016-0616-2" @default.
• W2401931799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27236438" @default.
• W2401931799 hasPublicationYear "2016" @default.
• W2401931799 type Work @default.
• W2401931799 sameAs 2401931799 @default.
• W2401931799 citedByCount "12" @default.
• W2401931799 countsByYear W24019317992017 @default.
• W2401931799 countsByYear W24019317992018 @default.
• W2401931799 countsByYear W24019317992019 @default.
• W2401931799 countsByYear W24019317992020 @default.
• W2401931799 countsByYear W24019317992021 @default.
• W2401931799 crossrefType "journal-article" @default.
• W2401931799 hasAuthorship W2401931799A5008740185 @default.
• W2401931799 hasAuthorship W2401931799A5012441260 @default.
• W2401931799 hasAuthorship W2401931799A5015183700 @default.
• W2401931799 hasAuthorship W2401931799A5049246136 @default.
• W2401931799 hasAuthorship W2401931799A5059967888 @default.
• W2401931799 hasAuthorship W2401931799A5064856279 @default.
• W2401931799 hasAuthorship W2401931799A5072372977 @default.
• W2401931799 hasAuthorship W2401931799A5085844474 @default.
• W2401931799 hasAuthorship W2401931799A5088527994 @default.
• W2401931799 hasAuthorship W2401931799A5090669318 @default.
• W2401931799 hasAuthorship W2401931799A5091341412 @default.
• W2401931799 hasBestOaLocation W24019317991 @default.
• W2401931799 hasConcept C104317684 @default.
• W2401931799 hasConcept C117717151 @default.
• W2401931799 hasConcept C121608353 @default.
• W2401931799 hasConcept C126322002 @default.
• W2401931799 hasConcept C142724271 @default.
• W2401931799 hasConcept C150194340 @default.
• W2401931799 hasConcept C180754005 @default.
• W2401931799 hasConcept C190727270 @default.
• W2401931799 hasConcept C2779767149 @default.
• W2401931799 hasConcept C2780140570 @default.
• W2401931799 hasConcept C502942594 @default.
• W2401931799 hasConcept C54355233 @default.
• W2401931799 hasConcept C61320498 @default.
• W2401931799 hasConcept C71924100 @default.
• W2401931799 hasConcept C86803240 @default.
• W2401931799 hasConceptScore W2401931799C104317684 @default.
• W2401931799 hasConceptScore W2401931799C117717151 @default.
• W2401931799 hasConceptScore W2401931799C121608353 @default.
• W2401931799 hasConceptScore W2401931799C126322002 @default.
• W2401931799 hasConceptScore W2401931799C142724271 @default.
• W2401931799 hasConceptScore W2401931799C150194340 @default.
• W2401931799 hasConceptScore W2401931799C180754005 @default.
• W2401931799 hasConceptScore W2401931799C190727270 @default.
• W2401931799 hasConceptScore W2401931799C2779767149 @default.
• W2401931799 hasConceptScore W2401931799C2780140570 @default.
• W2401931799 hasConceptScore W2401931799C502942594 @default.

• next