Matches in SemOpenAlex for { <https://semopenalex.org/work/W2402093616> ?p ?o ?g. }
- W2402093616 endingPage "112" @default.
- W2402093616 startingPage "91" @default.
- W2402093616 abstract "Myelodysplastic syndromes (MDS) are characterized initially by ineffective hematopoiesis and subsequently the frequent development of acute myelogenous leukemias (AML). During the last 15 years, important progress has been made in the understanding of the biology and prognosis of myelodysplastic syndromes. Risk-adapted treatment strategies were established due to the high median age (60-75 years) of MDS-patients and the individual history of the disease (number of cytopenias, cytogenetical changes, transfusion requirements). The use of allogeneic bone marrow transplantation for MDS patients currently offers the only potentially curative treatment, but this treatment modality is not available for the most of the typical MDS-patients aged >60 years. Based on in-vitro findings analyzing the potential of several agents to differentiate or to stimulate hematopoietic progenitor cells a number of therapeutic options were evaluated in clinical trials: hematopoietic growth factors (e.g. erythropoietin, G-CSF), differentiation inducers (e.g. retinoids), or cytoprotective substances (amifostine). The role of immunsuppressive agents (antithymocyte globulin, cyclosporine A) either alone or in combination is being actively investigated. Using intensive cytotoxic treatment in patients with advanced MDS or AML after MDS complete remission rates comparable with those known from the treatment of de novo AML were reported. The therapy related toxicity (early death rate <10%) was reduced by using G-CSF given prior (Priming) and/or after the cytotoxic treatment." @default.
- W2402093616 created "2016-06-24" @default.
- W2402093616 creator A5029332875 @default.
- W2402093616 creator A5066213019 @default.
- W2402093616 date "1999-01-01" @default.
- W2402093616 modified "2023-10-15" @default.
- W2402093616 title "Current Clinical Practice: Current Therapeutic Options in Myelodysplastic Syndromes" @default.
- W2402093616 cites W121813311 @default.
- W2402093616 cites W1519963426 @default.
- W2402093616 cites W1748624304 @default.
- W2402093616 cites W1813036123 @default.
- W2402093616 cites W1843902156 @default.
- W2402093616 cites W1851142847 @default.
- W2402093616 cites W187238933 @default.
- W2402093616 cites W1879738845 @default.
- W2402093616 cites W1937538988 @default.
- W2402093616 cites W1964924109 @default.
- W2402093616 cites W1967663757 @default.
- W2402093616 cites W1973034088 @default.
- W2402093616 cites W1976737212 @default.
- W2402093616 cites W1977285287 @default.
- W2402093616 cites W1979820704 @default.
- W2402093616 cites W1981323428 @default.
- W2402093616 cites W1984734984 @default.
- W2402093616 cites W1988062919 @default.
- W2402093616 cites W1988600618 @default.
- W2402093616 cites W1989289161 @default.
- W2402093616 cites W1990823806 @default.
- W2402093616 cites W1991796424 @default.
- W2402093616 cites W1993317268 @default.
- W2402093616 cites W1993470092 @default.
- W2402093616 cites W1995314148 @default.
- W2402093616 cites W1995837413 @default.
- W2402093616 cites W1995891393 @default.
- W2402093616 cites W1996432413 @default.
- W2402093616 cites W1998784653 @default.
- W2402093616 cites W2002622278 @default.
- W2402093616 cites W2004074207 @default.
- W2402093616 cites W2007402492 @default.
- W2402093616 cites W2019779426 @default.
- W2402093616 cites W2021702638 @default.
- W2402093616 cites W2022106508 @default.
- W2402093616 cites W2025041979 @default.
- W2402093616 cites W2025394831 @default.
- W2402093616 cites W2025509120 @default.
- W2402093616 cites W2027178014 @default.
- W2402093616 cites W2027850525 @default.
- W2402093616 cites W2028608893 @default.
- W2402093616 cites W2029138681 @default.
- W2402093616 cites W2035523033 @default.
- W2402093616 cites W2036049004 @default.
- W2402093616 cites W2036088433 @default.
- W2402093616 cites W2036591018 @default.
- W2402093616 cites W2037179719 @default.
- W2402093616 cites W2038056459 @default.
- W2402093616 cites W2040128160 @default.
- W2402093616 cites W2041726818 @default.
- W2402093616 cites W2042267697 @default.
- W2402093616 cites W2043366791 @default.
- W2402093616 cites W2043645419 @default.
- W2402093616 cites W2044197088 @default.
- W2402093616 cites W2045216843 @default.
- W2402093616 cites W2045507683 @default.
- W2402093616 cites W2046808658 @default.
- W2402093616 cites W2048791837 @default.
- W2402093616 cites W2049657694 @default.
- W2402093616 cites W2050403417 @default.
- W2402093616 cites W2055101497 @default.
- W2402093616 cites W2056555300 @default.
- W2402093616 cites W2057002824 @default.
- W2402093616 cites W2058125271 @default.
- W2402093616 cites W2060128775 @default.
- W2402093616 cites W2066608555 @default.
- W2402093616 cites W2069895841 @default.
- W2402093616 cites W2072503775 @default.
- W2402093616 cites W2073670731 @default.
- W2402093616 cites W2076649378 @default.
- W2402093616 cites W2079036256 @default.
- W2402093616 cites W2079763351 @default.
- W2402093616 cites W2080908313 @default.
- W2402093616 cites W2086161707 @default.
- W2402093616 cites W2092882953 @default.
- W2402093616 cites W2093702073 @default.
- W2402093616 cites W2093876750 @default.
- W2402093616 cites W2098491758 @default.
- W2402093616 cites W2107357720 @default.
- W2402093616 cites W2113177064 @default.
- W2402093616 cites W2124569538 @default.
- W2402093616 cites W2129530135 @default.
- W2402093616 cites W2132027522 @default.
- W2402093616 cites W2145750252 @default.
- W2402093616 cites W2147530468 @default.
- W2402093616 cites W2149683741 @default.
- W2402093616 cites W2149715600 @default.
- W2402093616 cites W2165846604 @default.
- W2402093616 cites W2168284025 @default.
- W2402093616 cites W2170707943 @default.
- W2402093616 cites W2175530672 @default.