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• W2402128504 abstract "No AccessJournal of Urology1 Oct 1990Characterization of Muscarinic Acetylcholine Receptors in Human Penile Corpus Cavernosum: Studies on Whole Tissue and Cultured Endothelium Abdulmaged M. Traish, Mary Pat Carson, Noel Kim, Irwin Goldstein, and Iñigo Saenz De Tejada Abdulmaged M. TraishAbdulmaged M. Traish More articles by this author , Mary Pat CarsonMary Pat Carson More articles by this author , Noel KimNoel Kim More articles by this author , Irwin GoldsteinIrwin Goldstein More articles by this author , and Iñigo Saenz De TejadaIñigo Saenz De Tejada More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)39653-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The binding characteristics of the muscarinic acetylcholine receptor antagonist, [3H] quinuclidinyl benzilate, to isolated membranes of human corpus cavernosum and endothelial cells, cultured from this tissue, were investigated. [3H] quinuclidinyl benzilate bound to membranes of human corpus cavernosum and endothelial cells with high affinity and limited capacity. Analysis of the binding data by Scatchard plot revealed the presence of one class of binding sites. The ligand binding specificity was determined by competitive binding assay. The data obtained show that [3H] quinuclidinyl benzilate was displaced by unlabeled competitors in the following order of efficacy in both membrane preparations: quinuclidinyl benzilate > scopolamine > atropine > 4-diphenylacetoxy-N-methyl-piperidine methiodide, M3 antagonist > pirenzepine, M1 antagonist > oxotremorine > (4-hydroxy-2-butynyl) trimethylammonium chloride m-chlorocarbanilate, M1 agonist > carbachol > hexamethonium. Solubilization of the muscarinic acetylcholine receptors from human corpus cavernosum and endothelial cells, with 1% digitonin and 0.02% cholate and subsequent analysis on sucrose density gradients, demonstrated the presence of a macromolecule specifically bound to [3H] quinuclidinyl benzilate sedimenting at the 6.2 S region of the gradient. These results demonstrate the presence of muscarinic acetylcholine receptors in human corpus cavernosum and in endothelial cells cultured from this tissue. (J. Urol., 144: 1036–1040, 1990) © 1990 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByCHOI Y, CHUNG W and CHOI H (2018) THE ACTION MECHANISM OF RELAXATION EFFECT OF ATROPINE ON THE ISOLATED RABBIT CORPUS CAVERNOSUMJournal of Urology, VOL. 161, NO. 6, (1976-1979), Online publication date: 1-Jun-1999.Lerner S, Melman A and Christ G (2018) A Review of Erectile Dysfunction: New Insights and More QuestionsJournal of Urology, VOL. 149, NO. 5 Part 2, (1246-1255), Online publication date: 1-May-1993.Knispel H, Goessl C and Beckmann R (2018) Basal and Acetylcholine-Stimulated Nitric Oxide Formation Mediates Relaxation of Rabbit Cavernous Smooth MuscleJournal of Urology, VOL. 146, NO. 5, (1429-1433), Online publication date: 1-Nov-1991. Volume 144Issue 4October 1990Page: 1036-1040 Advertisement Copyright & Permissions© 1990 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Abdulmaged M. Traish More articles by this author Mary Pat Carson More articles by this author Noel Kim More articles by this author Irwin Goldstein More articles by this author Iñigo Saenz De Tejada More articles by this author Expand All Advertisement Loading ..." @default.
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• W2402128504 title "Characterization of Muscarinic Acetylcholine Receptors in Human Penile Corpus Cavernosum: Studies on Whole Tissue and Cultured Endothelium" @default.
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