Matches in SemOpenAlex for { <https://semopenalex.org/work/W2402233904> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2402233904 endingPage "807" @default.
- W2402233904 startingPage "802" @default.
- W2402233904 abstract "Summary The authors have previously demonstrated that a low and intermittent peripheral dose of rapamycin (1 mg/kg three times/week) to rats inhibited mTORC1 signalling, but avoided the hyperlipidemia and diabetes‐like syndrome associated with higher doses of rapamycin. The dosing regimen reduced food intake, body weight, adiposity, serum leptin and triglycerides. mTORC1 signalling was inhibited in both liver and hypothalamus, suggesting some of the actions, in particular the decrease in food intake, may be the results of a central mechanism. To test this hypothesis, rapamycin (30 μg/day for 4 weeks) was infused into 23–25‐month‐old F344xBN rats by intracerebroventricular (icv) mini pumps. Our results demonstrated that central infusion did not alter food intake or body weight, although there was a tendency for a decrease in body weight towards the end of the study. mTORC1 signalling, evidenced by decreased phosphorylation of S6 protein at end of 4 weeks, was not activated in liver, hypothalamus or hindbrain. Fat and lean mass, sum of white adipose tissues, brown adipose tissue, serum glucose, insulin and leptin levels remained unchanged. Thus, these data suggest that the anorexic and body weight responses evident with peripheral rapamycin are not the result of direct central action. The tendency for decreased body weight towards the end of study, suggests that there is either a slow transport of centrally administered rapamycin into the periphery, or that there is delayed action of rapamycin at sites in the brain." @default.
- W2402233904 created "2016-06-24" @default.
- W2402233904 creator A5012789065 @default.
- W2402233904 creator A5040614096 @default.
- W2402233904 creator A5043797485 @default.
- W2402233904 creator A5055424104 @default.
- W2402233904 creator A5060767985 @default.
- W2402233904 creator A5070799377 @default.
- W2402233904 creator A5072500293 @default.
- W2402233904 creator A5074595773 @default.
- W2402233904 creator A5083927561 @default.
- W2402233904 date "2016-07-26" @default.
- W2402233904 modified "2023-10-05" @default.
- W2402233904 title "Anorexic response to rapamycin does not appear to involve a central mechanism" @default.
- W2402233904 cites W1915802091 @default.
- W2402233904 cites W1985820389 @default.
- W2402233904 cites W2035243857 @default.
- W2402233904 cites W2048376025 @default.
- W2402233904 cites W2050239879 @default.
- W2402233904 cites W2066898102 @default.
- W2402233904 cites W2080127092 @default.
- W2402233904 cites W2103806098 @default.
- W2402233904 cites W2114178491 @default.
- W2402233904 cites W2141243043 @default.
- W2402233904 cites W2144718202 @default.
- W2402233904 cites W2170851950 @default.
- W2402233904 cites W2277796992 @default.
- W2402233904 doi "https://doi.org/10.1111/1440-1681.12601" @default.
- W2402233904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5522742" @default.
- W2402233904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27232670" @default.
- W2402233904 hasPublicationYear "2016" @default.
- W2402233904 type Work @default.
- W2402233904 sameAs 2402233904 @default.
- W2402233904 citedByCount "9" @default.
- W2402233904 countsByYear W24022339042017 @default.
- W2402233904 countsByYear W24022339042018 @default.
- W2402233904 countsByYear W24022339042019 @default.
- W2402233904 countsByYear W24022339042021 @default.
- W2402233904 countsByYear W24022339042022 @default.
- W2402233904 crossrefType "journal-article" @default.
- W2402233904 hasAuthorship W2402233904A5012789065 @default.
- W2402233904 hasAuthorship W2402233904A5040614096 @default.
- W2402233904 hasAuthorship W2402233904A5043797485 @default.
- W2402233904 hasAuthorship W2402233904A5055424104 @default.
- W2402233904 hasAuthorship W2402233904A5060767985 @default.
- W2402233904 hasAuthorship W2402233904A5070799377 @default.
- W2402233904 hasAuthorship W2402233904A5072500293 @default.
- W2402233904 hasAuthorship W2402233904A5074595773 @default.
- W2402233904 hasAuthorship W2402233904A5083927561 @default.
- W2402233904 hasBestOaLocation W24022339042 @default.
- W2402233904 hasConcept C126322002 @default.
- W2402233904 hasConcept C134018914 @default.
- W2402233904 hasConcept C171089720 @default.
- W2402233904 hasConcept C185592680 @default.
- W2402233904 hasConcept C2777003273 @default.
- W2402233904 hasConcept C2779306644 @default.
- W2402233904 hasConcept C2780613262 @default.
- W2402233904 hasConcept C511355011 @default.
- W2402233904 hasConcept C55493867 @default.
- W2402233904 hasConcept C62478195 @default.
- W2402233904 hasConcept C71924100 @default.
- W2402233904 hasConcept C86554907 @default.
- W2402233904 hasConcept C98490376 @default.
- W2402233904 hasConceptScore W2402233904C126322002 @default.
- W2402233904 hasConceptScore W2402233904C134018914 @default.
- W2402233904 hasConceptScore W2402233904C171089720 @default.
- W2402233904 hasConceptScore W2402233904C185592680 @default.
- W2402233904 hasConceptScore W2402233904C2777003273 @default.
- W2402233904 hasConceptScore W2402233904C2779306644 @default.
- W2402233904 hasConceptScore W2402233904C2780613262 @default.
- W2402233904 hasConceptScore W2402233904C511355011 @default.
- W2402233904 hasConceptScore W2402233904C55493867 @default.
- W2402233904 hasConceptScore W2402233904C62478195 @default.
- W2402233904 hasConceptScore W2402233904C71924100 @default.
- W2402233904 hasConceptScore W2402233904C86554907 @default.
- W2402233904 hasConceptScore W2402233904C98490376 @default.
- W2402233904 hasIssue "9" @default.
- W2402233904 hasLocation W24022339041 @default.
- W2402233904 hasLocation W24022339042 @default.
- W2402233904 hasLocation W24022339043 @default.
- W2402233904 hasLocation W24022339044 @default.
- W2402233904 hasOpenAccess W2402233904 @default.
- W2402233904 hasPrimaryLocation W24022339041 @default.
- W2402233904 hasRelatedWork W1967954429 @default.
- W2402233904 hasRelatedWork W1976946227 @default.
- W2402233904 hasRelatedWork W2022716990 @default.
- W2402233904 hasRelatedWork W2033840628 @default.
- W2402233904 hasRelatedWork W2074115578 @default.
- W2402233904 hasRelatedWork W2074825053 @default.
- W2402233904 hasRelatedWork W2099969362 @default.
- W2402233904 hasRelatedWork W2106570883 @default.
- W2402233904 hasRelatedWork W2114343773 @default.
- W2402233904 hasRelatedWork W2348811830 @default.
- W2402233904 hasVolume "43" @default.
- W2402233904 isParatext "false" @default.
- W2402233904 isRetracted "false" @default.
- W2402233904 magId "2402233904" @default.
- W2402233904 workType "article" @default.