Matches in SemOpenAlex for { <https://semopenalex.org/work/W2402314386> ?p ?o ?g. }
- W2402314386 endingPage "283" @default.
- W2402314386 startingPage "264" @default.
- W2402314386 abstract "This study explores a series of hypotheses related to modulation of bone formation using the distraction model. The tibial lengthening model was scaled down from dog to rat to use immunohistochemistry, in situ hybridization, and reverse transcription-polymerase chain reaction to evaluate cellular events during in vivo bone formation. Different delivery systems such as oral, intragastric, intravenous, subcutaneous, and local diffusion by either extraperiosteal or intramedullary routes, were developed and standardized. Systemic modulators, including diet (total enteral nutrition, calcium, phosphate, soy, whey, casein, lead, and alcohol) and hormones (estrogen, testosterone, growth hormone, and gonadectomy), were tested. To investigate the effects of aging on bone formation, rats of different age groups had tibial lengthening. The aging effect could be distinguished by a reproducible deficiency of endosteal bone formation, consistent with similar deficits in older adult patients having distraction osteogenesis or in patients with senile osteoporosis. Expression of endogenous fibroblast growth factor-2 at the cellular level during the coupled osteogenesis and angiogenesis in young rats was dramatically diminished in old rats. Exogenous fibroblast growth factor-2 reversed the endosteal deficits found in old rats having distraction osteogenesis." @default.
- W2402314386 created "2016-06-24" @default.
- W2402314386 creator A5038467519 @default.
- W2402314386 date "2004-08-01" @default.
- W2402314386 modified "2023-10-07" @default.
- W2402314386 title "The Nicolas Andry Award: Modulation of Distraction Osteogenesis in the Aged Rat by Fibroblast Growth Factor" @default.
- W2402314386 cites W1216250604 @default.
- W2402314386 cites W1969758042 @default.
- W2402314386 cites W1974749337 @default.
- W2402314386 cites W1982989235 @default.
- W2402314386 cites W1984993196 @default.
- W2402314386 cites W1990747230 @default.
- W2402314386 cites W1997819158 @default.
- W2402314386 cites W2004659671 @default.
- W2402314386 cites W2005082224 @default.
- W2402314386 cites W2008007351 @default.
- W2402314386 cites W2010901408 @default.
- W2402314386 cites W2013011415 @default.
- W2402314386 cites W2013831105 @default.
- W2402314386 cites W2021189984 @default.
- W2402314386 cites W2025158872 @default.
- W2402314386 cites W2026769653 @default.
- W2402314386 cites W2029454379 @default.
- W2402314386 cites W2051199194 @default.
- W2402314386 cites W2056501398 @default.
- W2402314386 cites W2063768386 @default.
- W2402314386 cites W2075355561 @default.
- W2402314386 cites W2077548043 @default.
- W2402314386 cites W2078366245 @default.
- W2402314386 cites W2085046244 @default.
- W2402314386 cites W2085644952 @default.
- W2402314386 cites W2086282996 @default.
- W2402314386 cites W2086564192 @default.
- W2402314386 cites W2093811536 @default.
- W2402314386 cites W2104668613 @default.
- W2402314386 cites W2117926896 @default.
- W2402314386 cites W2123521997 @default.
- W2402314386 cites W2137305295 @default.
- W2402314386 cites W2158351424 @default.
- W2402314386 cites W2161764708 @default.
- W2402314386 cites W2163278516 @default.
- W2402314386 cites W2167091901 @default.
- W2402314386 cites W2168981489 @default.
- W2402314386 cites W2182382119 @default.
- W2402314386 cites W2319545737 @default.
- W2402314386 cites W2335011544 @default.
- W2402314386 cites W2335404538 @default.
- W2402314386 cites W2341093174 @default.
- W2402314386 cites W4236678309 @default.
- W2402314386 cites W4292425573 @default.
- W2402314386 cites W4294767948 @default.
- W2402314386 cites W4319307321 @default.
- W2402314386 cites W4376595643 @default.
- W2402314386 doi "https://doi.org/10.1097/01.blo.0000138186.53426.f9" @default.
- W2402314386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15292818" @default.
- W2402314386 hasPublicationYear "2004" @default.
- W2402314386 type Work @default.
- W2402314386 sameAs 2402314386 @default.
- W2402314386 citedByCount "31" @default.
- W2402314386 countsByYear W24023143862012 @default.
- W2402314386 countsByYear W24023143862013 @default.
- W2402314386 countsByYear W24023143862015 @default.
- W2402314386 countsByYear W24023143862016 @default.
- W2402314386 countsByYear W24023143862019 @default.
- W2402314386 countsByYear W24023143862020 @default.
- W2402314386 countsByYear W24023143862021 @default.
- W2402314386 countsByYear W24023143862022 @default.
- W2402314386 crossrefType "journal-article" @default.
- W2402314386 hasAuthorship W2402314386A5038467519 @default.
- W2402314386 hasConcept C126322002 @default.
- W2402314386 hasConcept C134018914 @default.
- W2402314386 hasConcept C141071460 @default.
- W2402314386 hasConcept C169760540 @default.
- W2402314386 hasConcept C170493617 @default.
- W2402314386 hasConcept C2775960820 @default.
- W2402314386 hasConcept C2776378700 @default.
- W2402314386 hasConcept C2776541429 @default.
- W2402314386 hasConcept C2776819169 @default.
- W2402314386 hasConcept C2777164284 @default.
- W2402314386 hasConcept C2780394083 @default.
- W2402314386 hasConcept C71924100 @default.
- W2402314386 hasConcept C74373430 @default.
- W2402314386 hasConcept C8337478 @default.
- W2402314386 hasConcept C86803240 @default.
- W2402314386 hasConceptScore W2402314386C126322002 @default.
- W2402314386 hasConceptScore W2402314386C134018914 @default.
- W2402314386 hasConceptScore W2402314386C141071460 @default.
- W2402314386 hasConceptScore W2402314386C169760540 @default.
- W2402314386 hasConceptScore W2402314386C170493617 @default.
- W2402314386 hasConceptScore W2402314386C2775960820 @default.
- W2402314386 hasConceptScore W2402314386C2776378700 @default.
- W2402314386 hasConceptScore W2402314386C2776541429 @default.
- W2402314386 hasConceptScore W2402314386C2776819169 @default.
- W2402314386 hasConceptScore W2402314386C2777164284 @default.
- W2402314386 hasConceptScore W2402314386C2780394083 @default.
- W2402314386 hasConceptScore W2402314386C71924100 @default.
- W2402314386 hasConceptScore W2402314386C74373430 @default.
- W2402314386 hasConceptScore W2402314386C8337478 @default.