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• W2402319960 endingPage "7008" @default.
• W2402319960 startingPage "6996" @default.
• W2402319960 abstract "Here we have investigated the effect of enshrouding polymer-coated nanoparticles (NPs) with polyethylene glycol (PEG) on the adsorption of proteins and uptake by cultured cells. PEG was covalently linked to the polymer surface to the maximal grafting density achievable under our experimental conditions. Changes in the effective hydrodynamic radius of the NPs upon adsorption of human serum albumin (HSA) and fibrinogen (FIB) were measured in situ using fluorescence correlation spectroscopy. For NPs without a PEG shell, a thickness increase of around 3 nm, corresponding to HSA monolayer adsorption, was measured at high HSA concentration. Only 50% of this value was found for NPs with PEGylated surfaces. While the size increase clearly reveals formation of a protein corona also for PEGylated NPs, fluorescence lifetime measurements and quenching experiments suggest that the adsorbed HSA molecules are buried within the PEG shell. For FIB adsorption onto PEGylated NPs, even less change in NP diameter was observed. In vitro uptake of the NPs by 3T3 fibroblasts was reduced to around 10% upon PEGylation with PEG chains of 10 kDa. Thus, even though the PEG coatings did not completely prevent protein adsorption, the PEGylated NPs still displayed a pronounced reduction of cellular uptake with respect to bare NPs, which is to be expected if the adsorbed proteins are not exposed on the NP surface." @default.
• W2402319960 created "2016-06-24" @default.
• W2402319960 creator A5006395432 @default.
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• W2402319960 creator A5091857882 @default.
• W2402319960 date "2015-06-25" @default.
• W2402319960 modified "2023-10-18" @default.
• W2402319960 title "Surface Functionalization of Nanoparticles with Polyethylene Glycol: Effects on Protein Adsorption and Cellular Uptake" @default.
• W2402319960 cites W1599568592 @default.
• W2402319960 cites W1967509243 @default.
• W2402319960 cites W1970598096 @default.
• W2402319960 cites W1973831032 @default.
• W2402319960 cites W1975982747 @default.
• W2402319960 cites W1980599353 @default.
• W2402319960 cites W1983742281 @default.
• W2402319960 cites W1983945471 @default.
• W2402319960 cites W1985144438 @default.
• W2402319960 cites W1986313397 @default.
• W2402319960 cites W1988217845 @default.
• W2402319960 cites W1989913459 @default.
• W2402319960 cites W1994055971 @default.
• W2402319960 cites W1994105157 @default.
• W2402319960 cites W1994470429 @default.
• W2402319960 cites W1995279009 @default.
• W2402319960 cites W1996139192 @default.
• W2402319960 cites W1996520089 @default.
• W2402319960 cites W1996993122 @default.
• W2402319960 cites W1997023256 @default.
• W2402319960 cites W1999156535 @default.
• W2402319960 cites W1999546585 @default.
• W2402319960 cites W2000865230 @default.
• W2402319960 cites W2005037415 @default.
• W2402319960 cites W2009805582 @default.
• W2402319960 cites W2012368513 @default.
• W2402319960 cites W2012412441 @default.
• W2402319960 cites W2013019179 @default.
• W2402319960 cites W2013557720 @default.
• W2402319960 cites W2017624562 @default.
• W2402319960 cites W2019305203 @default.
• W2402319960 cites W2019947866 @default.
• W2402319960 cites W2022254855 @default.
• W2402319960 cites W2029490817 @default.
• W2402319960 cites W2030603141 @default.
• W2402319960 cites W2032654453 @default.
• W2402319960 cites W2034383665 @default.
• W2402319960 cites W2034555772 @default.
• W2402319960 cites W2036136540 @default.
• W2402319960 cites W2036532945 @default.
• W2402319960 cites W2036633001 @default.
• W2402319960 cites W2038246612 @default.
• W2402319960 cites W2039689914 @default.
• W2402319960 cites W2040845319 @default.
• W2402319960 cites W2042949277 @default.
• W2402319960 cites W2044000481 @default.
• W2402319960 cites W2045178532 @default.
• W2402319960 cites W2045260522 @default.
• W2402319960 cites W2045847395 @default.
• W2402319960 cites W2047838167 @default.
• W2402319960 cites W2051489942 @default.
• W2402319960 cites W2054219881 @default.
• W2402319960 cites W2054847598 @default.
• W2402319960 cites W2055561333 @default.
• W2402319960 cites W2055660637 @default.
• W2402319960 cites W2056120938 @default.
• W2402319960 cites W2059960208 @default.
• W2402319960 cites W2062155582 @default.
• W2402319960 cites W2064636526 @default.
• W2402319960 cites W2064724563 @default.
• W2402319960 cites W2064863505 @default.
• W2402319960 cites W2070935955 @default.
• W2402319960 cites W2072457545 @default.
• W2402319960 cites W2073186966 @default.
• W2402319960 cites W2074139312 @default.
• W2402319960 cites W2074777798 @default.
• W2402319960 cites W2077707599 @default.
• W2402319960 cites W2079250812 @default.
• W2402319960 cites W2080008975 @default.
• W2402319960 cites W2080039056 @default.
• W2402319960 cites W2085026278 @default.
• W2402319960 cites W2093197613 @default.
• W2402319960 cites W2093606848 @default.
• W2402319960 cites W2095406047 @default.
• W2402319960 cites W2097269403 @default.
• W2402319960 cites W2099506163 @default.
• W2402319960 cites W2102606231 @default.
• W2402319960 cites W2103716701 @default.
• W2402319960 cites W2104223334 @default.
• W2402319960 cites W2107423984 @default.
• W2402319960 cites W2107554012 @default.
• W2402319960 cites W2119550206 @default.
• W2402319960 cites W2122046010 @default.
• W2402319960 cites W2126184258 @default.

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