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• W2402371805 startingPage "297" @default.
• W2402371805 abstract "Parkinson’s disease (PD) is well known for motor deficits such as bradykinesia. However, patients often experience additional deficits in working memory, behavioral selection, decision-making and other executive functions. Like other features of PD, the incidence and severity of these cognitive symptoms differ in males and females. However, preclinical models have not been used to systematically investigate the roles that sex or sex hormones may play in these complex signs. To address this, we used a Barnes maze spatial memory paradigm to compare the effects of a bilateral nigrostriatal dopamine lesion model of early PD on cognitive behaviors in adult male and female rats and in adult male rats that were gonadectomized or gonadectomized and supplemented with testosterone or estradiol. We found that dopamine lesions produced deficits in working memory and other executive operations, albeit only in male rats where circulating androgen levels were physiological. In males where androgen levels were depleted, lesions produced no additional Barnes maze deficits and attenuated those previously linked to androgen deprivation. We also found that while most measures of Barnes maze performance were unaffected by dopamine lesions in the females, lesions did induce dramatic shifts from their preferred use of thigmotactic navigation to the use of spatially guided place strategies similar to those normally preferred by males. These and other sex- and sex hormone-specific differences in the effects of nigrostriatal dopamine lesions on executive function highlight the potential of gonadal steroids as protective and/or therapeutic for the cognitive symptoms of PD. However, their complexity also indicates the need for a more thorough understanding of androgen and estrogen effects in guiding the development of hormone therapies that might effectively address these non-motor signs." @default.
• W2402371805 created "2016-06-24" @default.
• W2402371805 creator A5000318351 @default.
• W2402371805 creator A5023372376 @default.
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• W2402371805 creator A5054271535 @default.
• W2402371805 creator A5057909119 @default.
• W2402371805 creator A5081076635 @default.
• W2402371805 date "2017-03-01" @default.
• W2402371805 modified "2023-10-10" @default.
• W2402371805 title "The impact of biological sex and sex hormones on cognition in a rat model of early, pre-motor Parkinson’s disease" @default.
• W2402371805 cites W1479935944 @default.
• W2402371805 cites W1490631519 @default.
• W2402371805 cites W1506563231 @default.
• W2402371805 cites W1515063135 @default.
• W2402371805 cites W1541154230 @default.
• W2402371805 cites W1545877169 @default.
• W2402371805 cites W1577984325 @default.
• W2402371805 cites W1805914682 @default.
• W2402371805 cites W1930863496 @default.
• W2402371805 cites W1969628745 @default.
• W2402371805 cites W1971736309 @default.
• W2402371805 cites W1972106608 @default.
• W2402371805 cites W1974432189 @default.
• W2402371805 cites W1976634456 @default.
• W2402371805 cites W1976652826 @default.
• W2402371805 cites W1976676734 @default.
• W2402371805 cites W1977252372 @default.
• W2402371805 cites W1979455727 @default.
• W2402371805 cites W1980724469 @default.
• W2402371805 cites W1981037418 @default.
• W2402371805 cites W1981353792 @default.
• W2402371805 cites W1982557547 @default.
• W2402371805 cites W1983937997 @default.
• W2402371805 cites W1984315717 @default.
• W2402371805 cites W1984708543 @default.
• W2402371805 cites W1985118959 @default.
• W2402371805 cites W1989153256 @default.
• W2402371805 cites W1989643757 @default.
• W2402371805 cites W1993241967 @default.
• W2402371805 cites W1993653633 @default.
• W2402371805 cites W1995744319 @default.
• W2402371805 cites W1997431826 @default.
• W2402371805 cites W1998396025 @default.
• W2402371805 cites W1999915008 @default.
• W2402371805 cites W2003393707 @default.
• W2402371805 cites W2005394619 @default.
• W2402371805 cites W2006317352 @default.
• W2402371805 cites W2008301991 @default.
• W2402371805 cites W2015770890 @default.
• W2402371805 cites W2017946180 @default.
• W2402371805 cites W2018601731 @default.
• W2402371805 cites W2019749669 @default.
• W2402371805 cites W2020910786 @default.
• W2402371805 cites W2022425735 @default.
• W2402371805 cites W2022594955 @default.
• W2402371805 cites W2023404393 @default.
• W2402371805 cites W2023787112 @default.
• W2402371805 cites W2024403313 @default.
• W2402371805 cites W2024654139 @default.
• W2402371805 cites W2028798264 @default.
• W2402371805 cites W2028916479 @default.
• W2402371805 cites W2029680410 @default.
• W2402371805 cites W2030777545 @default.
• W2402371805 cites W2033279302 @default.
• W2402371805 cites W2035706316 @default.
• W2402371805 cites W2047824855 @default.
• W2402371805 cites W2049184686 @default.
• W2402371805 cites W2054235149 @default.
• W2402371805 cites W2054368817 @default.
• W2402371805 cites W2055411585 @default.
• W2402371805 cites W2055433370 @default.
• W2402371805 cites W2057443674 @default.
• W2402371805 cites W2058007888 @default.
• W2402371805 cites W2058224577 @default.
• W2402371805 cites W2058543084 @default.
• W2402371805 cites W2059389314 @default.
• W2402371805 cites W2063275916 @default.
• W2402371805 cites W2065226845 @default.
• W2402371805 cites W2065909153 @default.
• W2402371805 cites W2067061341 @default.
• W2402371805 cites W2067313980 @default.
• W2402371805 cites W2069804653 @default.
• W2402371805 cites W2070464021 @default.
• W2402371805 cites W2070835005 @default.
• W2402371805 cites W2070991943 @default.
• W2402371805 cites W2071329247 @default.
• W2402371805 cites W2072806037 @default.
• W2402371805 cites W2073130186 @default.
• W2402371805 cites W2074370892 @default.
• W2402371805 cites W2080028256 @default.
• W2402371805 cites W2084467300 @default.
• W2402371805 cites W2085250627 @default.
• W2402371805 cites W2086252264 @default.
• W2402371805 cites W2088558884 @default.
• W2402371805 cites W2089291555 @default.
• W2402371805 cites W2090111909 @default.
• W2402371805 cites W2091638564 @default.

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