FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2402448207> ?p ?o ?g. }

• W2402448207 abstract "Supratherapeutic vancomycin trough levels are common after trauma and associated with both increased acute kidney injury (AKI) and mortality. We sought to limit the adverse effects of vancomycin in trauma patients through more frequent trough monitoring.Beginning in January 2011, trauma patients treated with vancomycin had trough levels (VT) monitored daily until steady state was reached. Trauma patients admitted from January 2011 to May 2015 (POST) were compared with those admitted from January 2006 to December 2010 (PRE). Inclusion criteria required administration of intravenous vancomycin, admission serum creatinine (SCr), and SCr within 72 hours of highest VT. Acute kidney injury was defined as an increase in SCr of at least 0.3 mg/dL or 50% from admission to post-vancomycin administration. Those in the POST group were prospectively followed up until discharge or death.Two hundred sixty-three patients met inclusion criteria in the PRE-phase and 115 in the POST-phase. The two groups were similar in age, gender, race, body mass index, pre-existing comorbidities, admission systolic blood pressure, Glasgow Coma Scale, and head Abbreviated Injury Scale. Injury Severity Score was higher in the POST cohort (18 PRE vs. 25 POST, p < 0.001). Compared with PRE, the POST cohort had lower rates of supratherapeutic VT (>20 mg/L) (34.6% PRE vs. 22.6% POST, p = 0.02) and AKI (30.4% PRE vs. 19.1% POST, p = 0.026). After adjusting for confounders, the POST group had a significantly lower risk of AKI with an adjusted odds ratio of 0.457 (p = 0.027). There was a trend toward decreased mortality in the POST cohort, but this did not reach significance (10% PRE vs. 5.2% POST, p = 0.162).A reduction in AKI was observed in trauma patients with daily vancomycin trough levels monitored until steady state. Increased awareness regarding closer surveillance of VT in trauma patients may limit the incidence of vancomycin-related nephrotoxicity.Therapeutic study, level IV." @default.
• W2402448207 created "2016-06-24" @default.
• W2402448207 creator A5007134844 @default.
• W2402448207 creator A5010055942 @default.
• W2402448207 creator A5010718073 @default.
• W2402448207 creator A5033178700 @default.
• W2402448207 creator A5046981401 @default.
• W2402448207 creator A5060863322 @default.
• W2402448207 creator A5064520181 @default.
• W2402448207 creator A5069566241 @default.
• W2402448207 creator A5071648921 @default.
• W2402448207 creator A5076195342 @default.
• W2402448207 date "2016-08-01" @default.
• W2402448207 modified "2023-09-25" @default.
• W2402448207 title "Reducing acute kidney injury due to vancomycin in trauma patients" @default.
• W2402448207 cites W1964546753 @default.
• W2402448207 cites W1982348201 @default.
• W2402448207 cites W1991436621 @default.
• W2402448207 cites W2001914137 @default.
• W2402448207 cites W2011312924 @default.
• W2402448207 cites W2020306249 @default.
• W2402448207 cites W2038510079 @default.
• W2402448207 cites W2053473446 @default.
• W2402448207 cites W2054888306 @default.
• W2402448207 cites W2056026648 @default.
• W2402448207 cites W2061531071 @default.
• W2402448207 cites W2063673792 @default.
• W2402448207 cites W2065956479 @default.
• W2402448207 cites W2078293300 @default.
• W2402448207 cites W2089045777 @default.
• W2402448207 cites W2099365065 @default.
• W2402448207 cites W2108433768 @default.
• W2402448207 cites W2111442039 @default.
• W2402448207 cites W2116736766 @default.
• W2402448207 cites W2128183453 @default.
• W2402448207 cites W2133120422 @default.
• W2402448207 cites W2158657903 @default.
• W2402448207 cites W4211194064 @default.
• W2402448207 doi "https://doi.org/10.1097/ta.0000000000001105" @default.
• W2402448207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27192471" @default.
• W2402448207 hasPublicationYear "2016" @default.
• W2402448207 type Work @default.
• W2402448207 sameAs 2402448207 @default.
• W2402448207 citedByCount "0" @default.
• W2402448207 crossrefType "journal-article" @default.
• W2402448207 hasAuthorship W2402448207A5007134844 @default.
• W2402448207 hasAuthorship W2402448207A5010055942 @default.
• W2402448207 hasAuthorship W2402448207A5010718073 @default.
• W2402448207 hasAuthorship W2402448207A5033178700 @default.
• W2402448207 hasAuthorship W2402448207A5046981401 @default.
• W2402448207 hasAuthorship W2402448207A5060863322 @default.
• W2402448207 hasAuthorship W2402448207A5064520181 @default.
• W2402448207 hasAuthorship W2402448207A5069566241 @default.
• W2402448207 hasAuthorship W2402448207A5071648921 @default.
• W2402448207 hasAuthorship W2402448207A5076195342 @default.
• W2402448207 hasConcept C126322002 @default.
• W2402448207 hasConcept C156957248 @default.
• W2402448207 hasConcept C167135981 @default.
• W2402448207 hasConcept C17624336 @default.
• W2402448207 hasConcept C188816634 @default.
• W2402448207 hasConcept C190385971 @default.
• W2402448207 hasConcept C194828623 @default.
• W2402448207 hasConcept C2776567890 @default.
• W2402448207 hasConcept C2778980435 @default.
• W2402448207 hasConcept C2779489039 @default.
• W2402448207 hasConcept C2780110798 @default.
• W2402448207 hasConcept C2780306776 @default.
• W2402448207 hasConcept C2780472472 @default.
• W2402448207 hasConcept C3017944768 @default.
• W2402448207 hasConcept C42219234 @default.
• W2402448207 hasConcept C523546767 @default.
• W2402448207 hasConcept C54355233 @default.
• W2402448207 hasConcept C71924100 @default.
• W2402448207 hasConcept C72563966 @default.
• W2402448207 hasConcept C85004164 @default.
• W2402448207 hasConcept C86803240 @default.
• W2402448207 hasConceptScore W2402448207C126322002 @default.
• W2402448207 hasConceptScore W2402448207C156957248 @default.
• W2402448207 hasConceptScore W2402448207C167135981 @default.
• W2402448207 hasConceptScore W2402448207C17624336 @default.
• W2402448207 hasConceptScore W2402448207C188816634 @default.
• W2402448207 hasConceptScore W2402448207C190385971 @default.
• W2402448207 hasConceptScore W2402448207C194828623 @default.
• W2402448207 hasConceptScore W2402448207C2776567890 @default.
• W2402448207 hasConceptScore W2402448207C2778980435 @default.
• W2402448207 hasConceptScore W2402448207C2779489039 @default.
• W2402448207 hasConceptScore W2402448207C2780110798 @default.
• W2402448207 hasConceptScore W2402448207C2780306776 @default.
• W2402448207 hasConceptScore W2402448207C2780472472 @default.
• W2402448207 hasConceptScore W2402448207C3017944768 @default.
• W2402448207 hasConceptScore W2402448207C42219234 @default.
• W2402448207 hasConceptScore W2402448207C523546767 @default.
• W2402448207 hasConceptScore W2402448207C54355233 @default.
• W2402448207 hasConceptScore W2402448207C71924100 @default.
• W2402448207 hasConceptScore W2402448207C72563966 @default.
• W2402448207 hasConceptScore W2402448207C85004164 @default.
• W2402448207 hasConceptScore W2402448207C86803240 @default.
• W2402448207 hasLocation W24024482071 @default.
• W2402448207 hasLocation W24024482072 @default.
• W2402448207 hasOpenAccess W2402448207 @default.

• next