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- W2402508733 abstract "536 Objectives Owing to the direct correlation between functional and anatomical imaging, radioiodine single photon emission computed tomography with computed tomography (131I-SPECT/CT) is increasingly being used to evaluate patients with differentiated thyroid carcinoma (DTC). Serum thyroglobulin (Tg), cervical ultrasound (US) and 131I whole body scan form the basis of follow-up of DTC patients. Metastatic DTC with a positive 131I scintigraphy but negative stimulated Tg (sTg) is relatively rare in clinical practice. Methods A total of consecutive 3,367 histologically proven DTC patients were analyzed retrospectively from January 2007 to June 2013. Tg negativity was defined as a sTg level of Results Seventy one (median age 45, range 17-68) patients showed post-therapeutic 131I-SPECT/CT positive while sTg negative (PTP-TN) constituting 2.1% of all patients. Of the 71 eligible patients, 2 (2.8%) with bone metastasis, 11 (15.5%) with lung metastasis, 59 (83.1%) with lymph node metastasis were classified. 56 patients had cervical lymph node metastasis (cLNM), US showed positive in 15 paients (26.8%) while negative in 41 patients (73.2%). When compared to patients with concordant positive results of sTg and 131I scintigraphy, US showed relative lower positive rate in detection of cLNM in PTP-TN patients (28.8% vs. 53.8%; χ2=6.70; P=0.01). Conclusions Even with sTg" @default.
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- W2402508733 date "2015-05-01" @default.
- W2402508733 modified "2023-09-22" @default.
- W2402508733 title "Value of post-therapeutic 131I-SPECT/CT in stimulated serum thyroglobulin negative patients with metastatic differentiated thyroid carcinoma" @default.
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