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- W2402565443 abstract "The effects of berberine (0.1-10 mg/L) on delayed activation potassium current (iK) of canine Purkinje fibers were studied with two-microelectrode voltage clamp technique. Berberine (Ber) significantly reduced the amplitude of iK in concentration-dependent manner. When perfused with 10 mg/L Ber, the amplitude of tail current of the Purkinje fibers decreased immediately and the inhibition rate was 73.6 +/- 4.5% (n = 9, P < 0.001). The inhibition effect of berberine on iK may explain its prolongation effect on action potential duration and its antiarrhythmic action." @default.
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- W2402565443 date "1992-10-01" @default.
- W2402565443 modified "2023-09-25" @default.
- W2402565443 title "[A study of the antiarrhythmic mechanism of berberine on delayed activation potassium current by voltage clamp]." @default.
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