FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2402580193> ?p ?o ?g. }

• W2402580193 abstract "Adhesion molecules expressed on cerebral endothelial cells (ECs) mediate leukocyte recruitment and play a significant role in cerebral inflammation. Increased levels of adhesion molecules on the EC surface induce leukocyte infiltration into inflammatory areas and are thus hallmarkers of inflammation. Honokiol, isolated from the Chinese medicinal herb Magnolia officinalis, has various pharmacological activities, including anti-inflammatory effects, yet the nature of honokiol targeting molecules remains to be revealed. Here, we investigated the inhibitory effect of honokiol on neutrophil adhesion and vascular cell adhesion molecule-1 (VCAM-1) expression, which underlie its molecular target, and mechanisms for inactivating nuclear factor κ enhancer binding protein (NF-κB) in mouse cerebral ECs. Honokiol inhibited tumour necrosis factor-α (TNF-α)-induced neutrophil adhesion and VCAM-1 gene expression in cerebral ECs. The inflammatory transcription factor NF-κB was downregulated by honokiol. Honokiol significantly blocked TNF-α-induced NF-κB p65 nuclear translocation and degradation of the proteasome-dependent inhibitor of NF-κB α (IκBα). From docking model prediction, honokiol directly targeted the ubiquitin-ubiquitin interface of Lys48-linked polychains. Moreover, honokiol prevented the TNF-α-induced Lys48-linked polyubiquitination, including IκBα-polyubiquitin interaction. Honokiol has protective anti-inflammatory effects on TNF-α-induced neutrophil adhesion and VCAM-1 gene expression in cerebral ECs, at least in part by directly inhibiting ubiquitination-mediated IκBα degradation and then preventing NF-κB nuclear translocation." @default.
• W2402580193 created "2016-06-24" @default.
• W2402580193 creator A5007693722 @default.
• W2402580193 creator A5013734423 @default.
• W2402580193 creator A5018921271 @default.
• W2402580193 creator A5023692884 @default.
• W2402580193 creator A5061646312 @default.
• W2402580193 creator A5062046621 @default.
• W2402580193 creator A5066359340 @default.
• W2402580193 creator A5067600405 @default.
• W2402580193 date "2016-05-23" @default.
• W2402580193 modified "2023-10-12" @default.
• W2402580193 title "Honokiol suppresses TNF-α-induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of IκBα" @default.
• W2402580193 cites W1506569093 @default.
• W2402580193 cites W1592352685 @default.
• W2402580193 cites W1960809236 @default.
• W2402580193 cites W1968214306 @default.
• W2402580193 cites W1968326689 @default.
• W2402580193 cites W1973396195 @default.
• W2402580193 cites W1973963032 @default.
• W2402580193 cites W1978453275 @default.
• W2402580193 cites W1979854417 @default.
• W2402580193 cites W1987111128 @default.
• W2402580193 cites W1988180371 @default.
• W2402580193 cites W1996056620 @default.
• W2402580193 cites W1996630711 @default.
• W2402580193 cites W1999325378 @default.
• W2402580193 cites W2002148098 @default.
• W2402580193 cites W2003147175 @default.
• W2402580193 cites W2004768943 @default.
• W2402580193 cites W2004911329 @default.
• W2402580193 cites W2005770243 @default.
• W2402580193 cites W2026512029 @default.
• W2402580193 cites W2030958472 @default.
• W2402580193 cites W2035163714 @default.
• W2402580193 cites W2041182922 @default.
• W2402580193 cites W2043061500 @default.
• W2402580193 cites W2051617671 @default.
• W2402580193 cites W2051931627 @default.
• W2402580193 cites W2052907562 @default.
• W2402580193 cites W2055294078 @default.
• W2402580193 cites W2070390017 @default.
• W2402580193 cites W2073669171 @default.
• W2402580193 cites W2075300546 @default.
• W2402580193 cites W2075984442 @default.
• W2402580193 cites W2076966331 @default.
• W2402580193 cites W2076971614 @default.
• W2402580193 cites W2082748245 @default.
• W2402580193 cites W2083741449 @default.
• W2402580193 cites W2085869287 @default.
• W2402580193 cites W2086779539 @default.
• W2402580193 cites W2091864309 @default.
• W2402580193 cites W2094863064 @default.
• W2402580193 cites W2095594249 @default.
• W2402580193 cites W2099854686 @default.
• W2402580193 cites W2101026205 @default.
• W2402580193 cites W2101078720 @default.
• W2402580193 cites W2103133890 @default.
• W2402580193 cites W2106265598 @default.
• W2402580193 cites W2111100642 @default.
• W2402580193 cites W2111483928 @default.
• W2402580193 cites W2123494510 @default.
• W2402580193 cites W2124450273 @default.
• W2402580193 cites W2128956141 @default.
• W2402580193 cites W2129588158 @default.
• W2402580193 cites W2129940081 @default.
• W2402580193 cites W2132629607 @default.
• W2402580193 cites W2136568191 @default.
• W2402580193 cites W2138317404 @default.
• W2402580193 cites W2143156516 @default.
• W2402580193 cites W2151679290 @default.
• W2402580193 cites W2159821105 @default.
• W2402580193 cites W2164361483 @default.
• W2402580193 cites W2165500494 @default.
• W2402580193 cites W2169909652 @default.
• W2402580193 cites W2176516200 @default.
• W2402580193 cites W2312313151 @default.
• W2402580193 doi "https://doi.org/10.1038/srep26554" @default.
• W2402580193 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4876378" @default.
• W2402580193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27212040" @default.
• W2402580193 hasPublicationYear "2016" @default.
• W2402580193 type Work @default.
• W2402580193 sameAs 2402580193 @default.
• W2402580193 citedByCount "41" @default.
• W2402580193 countsByYear W24025801932017 @default.
• W2402580193 countsByYear W24025801932018 @default.
• W2402580193 countsByYear W24025801932019 @default.
• W2402580193 countsByYear W24025801932020 @default.
• W2402580193 countsByYear W24025801932021 @default.
• W2402580193 countsByYear W24025801932022 @default.
• W2402580193 countsByYear W24025801932023 @default.
• W2402580193 crossrefType "journal-article" @default.
• W2402580193 hasAuthorship W2402580193A5007693722 @default.
• W2402580193 hasAuthorship W2402580193A5013734423 @default.
• W2402580193 hasAuthorship W2402580193A5018921271 @default.
• W2402580193 hasAuthorship W2402580193A5023692884 @default.
• W2402580193 hasAuthorship W2402580193A5061646312 @default.
• W2402580193 hasAuthorship W2402580193A5062046621 @default.
• W2402580193 hasAuthorship W2402580193A5066359340 @default.
• W2402580193 hasAuthorship W2402580193A5067600405 @default.

• next