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- W2402819744 abstract "Ninety-two patients with advanced non-small cell lung cancer were treated with a combination chemotherapy regimen containing cisplatin, vindesine, and etoposide. Eighteen patients (20%) achieved major responses to therapy (three complete responders and 15 partial responders). Response rates were similar in each histologic subtype. Initial performance status was an important determinant of response; 42% of the patients with a Karnofsky performance status greater than or equal to 70% responded versus 5% of those with a performance status less than 50%. The median duration of partial response was 21 weeks; complete responders had a median response duration of 50 weeks. The median survival for the entire group was 23.5 weeks. Toxicity with this regimen was acceptable; myelosuppression was the major toxic effect and was severe in only 10% of the patients. This regimen produced response rates comparable to those reported with other combinations containing cisplatin. Survival advantage in patients receiving this treatment is not established." @default.
- W2402819744 created "2016-06-24" @default.
- W2402819744 date "1986-12-01" @default.
- W2402819744 modified "2023-09-26" @default.
- W2402819744 title "Combination chemotherapy with vindesine, etoposide, and cisplatin in non-small cell lung cancer: A pilot study of the southeastern cancer study group" @default.
- W2402819744 doi "https://doi.org/10.1016/s0169-5002(86)80797-8" @default.
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