Matches in SemOpenAlex for { <https://semopenalex.org/work/W2402823108> ?p ?o ?g. }
- W2402823108 endingPage "7621" @default.
- W2402823108 startingPage "7621" @default.
- W2402823108 abstract "Irritable bowel syndrome (IBS) is a common gastrointestinal disorder, the pathophysiology of which is not completely known, although it has been shown that genetic/social learning factors, diet, intestinal microbiota, intestinal low-grade inflammation, and abnormal gastrointestinal endocrine cells play a major role. Studies of familial aggregation and on twins have confirmed the heritability of IBS. However, the proposed IBS risk genes are thus far nonvalidated hits rather than true predisposing factors. There is no convincing evidence that IBS patients suffer from food allergy/intolerance, with the effect exerted by diet seemingly caused by intake of poorly absorbed carbohydrates and fiber. Obesity is a possible comorbidity of IBS. Differences in the microbiota between IBS patients and healthy controls have been reported, but the association between IBS symptoms and specific bacterial species is uncertain. Low-grade inflammation appears to play a role in the pathophysiology of a major subset of IBS, namely postinfectious IBS. The density of intestinal endocrine cells is reduced in patients with IBS, possibly as a result of genetic factors, diet, intestinal microbiota, and low-grade inflammation interfering with the regulatory signals controlling the intestinal stem-cell clonogenic and differentiation activities. Furthermore, there is speculation that this decreased number of endocrine cells is responsible for the visceral hypersensitivity, disturbed gastrointestinal motility, and abnormal gut secretion seen in IBS patients." @default.
- W2402823108 created "2016-06-24" @default.
- W2402823108 creator A5084232540 @default.
- W2402823108 date "2015-01-01" @default.
- W2402823108 modified "2023-10-16" @default.
- W2402823108 title "Recent developments in the pathophysiology of irritable bowel syndrome" @default.
- W2402823108 cites W105760296 @default.
- W2402823108 cites W108475790 @default.
- W2402823108 cites W1483496013 @default.
- W2402823108 cites W1487811474 @default.
- W2402823108 cites W1508902445 @default.
- W2402823108 cites W1515428775 @default.
- W2402823108 cites W1536827165 @default.
- W2402823108 cites W1542508778 @default.
- W2402823108 cites W1544422657 @default.
- W2402823108 cites W1565002994 @default.
- W2402823108 cites W1593526448 @default.
- W2402823108 cites W1608239285 @default.
- W2402823108 cites W1731897847 @default.
- W2402823108 cites W1749076916 @default.
- W2402823108 cites W182568401 @default.
- W2402823108 cites W1828912035 @default.
- W2402823108 cites W1853525790 @default.
- W2402823108 cites W1869880021 @default.
- W2402823108 cites W1894573884 @default.
- W2402823108 cites W1907622199 @default.
- W2402823108 cites W1923128715 @default.
- W2402823108 cites W1926772041 @default.
- W2402823108 cites W1931452900 @default.
- W2402823108 cites W1937309249 @default.
- W2402823108 cites W1960867647 @default.
- W2402823108 cites W1964383977 @default.
- W2402823108 cites W1964674551 @default.
- W2402823108 cites W1965487992 @default.
- W2402823108 cites W1965763611 @default.
- W2402823108 cites W1967491450 @default.
- W2402823108 cites W1967838039 @default.
- W2402823108 cites W1967848019 @default.
- W2402823108 cites W1967929674 @default.
- W2402823108 cites W1968110197 @default.
- W2402823108 cites W1969154910 @default.
- W2402823108 cites W1969517715 @default.
- W2402823108 cites W1969592211 @default.
- W2402823108 cites W1969936253 @default.
- W2402823108 cites W1970018781 @default.
- W2402823108 cites W1970178265 @default.
- W2402823108 cites W1972170969 @default.
- W2402823108 cites W1972486784 @default.
- W2402823108 cites W1972526677 @default.
- W2402823108 cites W1972565216 @default.
- W2402823108 cites W1972667757 @default.
- W2402823108 cites W1974114749 @default.
- W2402823108 cites W1974577714 @default.
- W2402823108 cites W1975266081 @default.
- W2402823108 cites W1975523098 @default.
- W2402823108 cites W1975590758 @default.
- W2402823108 cites W1976106554 @default.
- W2402823108 cites W1976522041 @default.
- W2402823108 cites W1979431125 @default.
- W2402823108 cites W1980175448 @default.
- W2402823108 cites W1980710038 @default.
- W2402823108 cites W1980848546 @default.
- W2402823108 cites W1982311411 @default.
- W2402823108 cites W1982427642 @default.
- W2402823108 cites W1982603620 @default.
- W2402823108 cites W1983650058 @default.
- W2402823108 cites W1983676019 @default.
- W2402823108 cites W1983986068 @default.
- W2402823108 cites W1984425552 @default.
- W2402823108 cites W1984468996 @default.
- W2402823108 cites W1984598136 @default.
- W2402823108 cites W1986328448 @default.
- W2402823108 cites W1986746242 @default.
- W2402823108 cites W1987126628 @default.
- W2402823108 cites W1987464611 @default.
- W2402823108 cites W1987654400 @default.
- W2402823108 cites W1988317557 @default.
- W2402823108 cites W1989075927 @default.
- W2402823108 cites W1989294017 @default.
- W2402823108 cites W1991519731 @default.
- W2402823108 cites W1992676701 @default.
- W2402823108 cites W1993839540 @default.
- W2402823108 cites W1993975781 @default.
- W2402823108 cites W1995318728 @default.
- W2402823108 cites W1996475379 @default.
- W2402823108 cites W1997901894 @default.
- W2402823108 cites W1999734650 @default.
- W2402823108 cites W2001416500 @default.
- W2402823108 cites W2001508112 @default.
- W2402823108 cites W2001790583 @default.
- W2402823108 cites W2002907969 @default.
- W2402823108 cites W2003572910 @default.
- W2402823108 cites W2003617540 @default.
- W2402823108 cites W2004471887 @default.
- W2402823108 cites W2004967319 @default.
- W2402823108 cites W2005719748 @default.
- W2402823108 cites W2006072769 @default.
- W2402823108 cites W2008266794 @default.