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- W2403170685 abstract "Dynamic modeling of the metabolism is one of the main research areas of systems biology. A typical but yet unresolved problem is the modeling of glucose uptake of Lactococcus lactis bacteria upon in-vivo NMR measurements in perturbation experiments. Most modelers are focusing on the inverse problem, namely to identify the parameters of a set of differential equations using the available dataset. Majority of the available models suffer from the drawback that even if a perfect fit to a single experiment was achieved, they can not explain the systems’ behavior in different experimental conditions. The aim of this study is to introduce an appropriate method and a model to fit one set of parameters to several different experiments, enabling unify modeling of the glucose decay of the bacteria. With the proposed approach a good overall fit was obtained to the dataset. The results confirm that this could be a future way towards unified modeling of data with heterogeneous experimental conditions." @default.
- W2403170685 created "2016-06-24" @default.
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- W2403170685 date "2011-01-01" @default.
- W2403170685 modified "2023-10-05" @default.
- W2403170685 title "UNIFIED MODELING OF SEVERAL PERTURBATION EXPERIMENTS IN SYSTEMS BIOLOGY - A Case Study on the Glucose Uptake of Lactococcus Lactis" @default.
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- W2403170685 doi "https://doi.org/10.5220/0003158103090312" @default.
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