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• W2403485509 abstract "Myopia is the most common eye disorder and major cause of visual impairment worldwide. As the incidence of myopia continues to rise, the need to further understand the complex roles of molecular and environmental factors controlling variation in refractive error is of increasing importance. Tkatchenko and colleagues applied a systematic approach using a combination of gene set enrichment analysis, genome-wide association studies, and functional analysis of a murine model to identify a myopia susceptibility gene, APLP2. Differential expression of refractive error was associated with time spent reading for those with low frequency variants in this gene. This provides support for the longstanding hypothesis of gene-environment interactions in refractive error development." @default.
• W2403485509 created "2016-06-24" @default.
• W2403485509 creator A5060258624 @default.
• W2403485509 date "2016-05-27" @default.
• W2403485509 modified "2023-09-25" @default.
• W2403485509 title "Nature versus nurture: A systematic approach to elucidate gene–environment interactions in the development of myopic refractive errors" @default.
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• W2403485509 doi "https://doi.org/10.1080/13816810.2016.1183216" @default.
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