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• W2403573190 abstract "Chronic stress or chronically high levels of glucocorticoids can result in memory impairment. This study aimed to investigate if 4,4′-dichloro-diphenyl diselenide (p-ClPhSe)2 reverses memory impairment-related to stress caused by corticosterone administration in mice and its possible mechanism of action. Swiss mice received corticosterone (20 μg/ml) in their drinking water during four weeks. In the last week, the animals were treated with (p-ClPhSe)2 (1 or 5 mg/kg) by the intragastric route (i.g.) once a day for 7 days. The cognitive performance of mice was assessed through the object recognition test (ORT), the object location test (OLT) and the step-down passive avoidance test (SDPA), some of predictive tests of memory. Biochemical parameters were determined and locomotor activity of mouse was performed to gain insight in (p-ClPhSe)2 toxicity. The findings demonstrated that treatment with (p-ClPhSe)2 in both doses was effective in reversing memory deficits in the ORT, the OLT and the SDPA caused by corticosterone exposure in mice. Treatment with (p-ClPhSe)2 at both doses reversed the increase in the [3H] glutamate uptake by hippocampal slices of mice treated with corticosterone. By contrast, [3H] glutamate uptake by brain cortical slices was not altered in mice exposed to corticosterone. The Na+ K+ ATPase activity was not altered in hippocampus and cerebral cortices of mice treated with corticosterone. There was no sign of toxicity in mice treated with (p-ClPhSe)2. This organoselenium compound reversed memory impairment-related to stress caused by corticosterone and modulated hippocampal [3H]glutamate uptake in mice." @default.
• W2403573190 created "2016-06-24" @default.
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• W2403573190 date "2016-10-01" @default.
• W2403573190 modified "2023-09-23" @default.
• W2403573190 title "p-Chloro-diphenyl diselenide reverses memory impairment-related to stress caused by corticosterone and modulates hippocampal [3H]glutamate uptake in mice" @default.
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• W2403573190 doi "https://doi.org/10.1016/j.physbeh.2016.05.029" @default.
• W2403573190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27211333" @default.
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