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- W2403600548 abstract "Hirschsprung's disease (HSCR) or congenital megacolon is one of the differential diagnoses of chronic constipation mostly in infancy and may indeed represent a challenge for pediatricians, pediatric surgeons, and pediatric pathologists. The diagnosis relies clearly on the identification of the absence of ganglion cells at the plexuses (submucosus and myentericus) of the bowel wall. HSCR is usually located at the terminal (distal) rectum with potential pre-terminal or proximal extension to the less distal large bowel (sigmoid colon). Astonishingly, there is some evidence that Hindu surgeons of prehistoric India may have been exposed and had considerable knowledge about HSCR, but this disease is notoriously and eponymously named to Dr. Harald Hirschsprung (1830-1916), who brilliantly presented two infants with fatal constipation at the Berlin conference of the German Society of Pediatrics more than one century ago. Historical milestones and diagnosis of HSCR (originally called Die Hirschsprungsche Krankheit) are reviewed. More than 100 years following his meticulous and broad description, HSCR is still a puzzling disease for both diagnosis and treatment. HSCR remains a critical area of clinical pediatrics and pediatric surgery and an intense area of investigation for both molecular and developmental biologists." @default.
- W2403600548 created "2016-06-24" @default.
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- W2403600548 date "2015-01-01" @default.
- W2403600548 modified "2023-09-30" @default.
- W2403600548 title "Hirschsprung’s disease: Historical notes and pathological diagnosis on the occasion of the 100<sup>th</sup>anniversary of Dr. Harald Hirschsprung’s death" @default.
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- W2403600548 doi "https://doi.org/10.5409/wjcp.v4.i4.120" @default.
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