Matches in SemOpenAlex for { <https://semopenalex.org/work/W2403661479> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2403661479 abstract "Introduction & Objectives. We have previously reported that response of prostate cancer (PC) to taxane therapy is based on the interplay between androgen receptor (AR) and c-jun However, the cellular mechanisms of taxane treatment in prostate cancer cells are not fully elucidated. The aim of this study was to investigate the effect of sustained down-regulation of c-jun on the outcome of taxane therapy using LNCaP cells transfected with c-jun shRNA, and to characterize the nature of the c-jun and AR interaction in regard to their corresponding promoter regions. Material & Methods. Chromatin immunoprecipitation (CHIP) assay was performed to examine gene recruitment. LNCaP cells were treated with Docetaxel (Doc) or Paclitaxel (Pac) and resulting chromatin preparations were analyzed by PCR. To analyse the impact of c-jun downregulation on AR and prostate cancer response to therapy we used LNCaP cells harboring stable knocked down c-jun (LNsiJun). Cells were exposed to Doc, Pac DHT for different time-points and the medium were subjected for PSA analysis using DELFIA 1234 fluorometer and cell response to drugs assessed by MTT assay. Results. Taxane treatment of LNsiJun cells led to a statistically significant decrease of cell viability compared to parental LNCaP cells (p Conclusions. In conclusion, down-regulation of endogenous c-jun enhances sensitivity of LNCaP cells to taxane treatment. Binding of AR to the c-jun promoter is taxane specific and results in different expression levels of AR and PSA. Citation Format: Nishtman Dizeyi, Martina V. Tinzl, Marieke van der Molen, Julius Semenas, Per-Anders Abrahamsson. Androgen receptor recruitment to c-Jun promoter region regulates chemosensitivity of prostate cancer cells to taxane therapy. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2015 Nov 5-9; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr B15." @default.
- W2403661479 created "2016-06-24" @default.
- W2403661479 creator A5016709333 @default.
- W2403661479 creator A5029258794 @default.
- W2403661479 creator A5043570965 @default.
- W2403661479 creator A5071538520 @default.
- W2403661479 creator A5074463161 @default.
- W2403661479 date "2015-12-01" @default.
- W2403661479 modified "2023-10-16" @default.
- W2403661479 title "Abstract B15: Androgen receptor recruitment to c-Jun promoter region regulates chemosensitivity of prostate cancer cells to taxane therapy" @default.
- W2403661479 doi "https://doi.org/10.1158/1535-7163.targ-15-b15" @default.
- W2403661479 hasPublicationYear "2015" @default.
- W2403661479 type Work @default.
- W2403661479 sameAs 2403661479 @default.
- W2403661479 citedByCount "0" @default.
- W2403661479 crossrefType "proceedings-article" @default.
- W2403661479 hasAuthorship W2403661479A5016709333 @default.
- W2403661479 hasAuthorship W2403661479A5029258794 @default.
- W2403661479 hasAuthorship W2403661479A5043570965 @default.
- W2403661479 hasAuthorship W2403661479A5071538520 @default.
- W2403661479 hasAuthorship W2403661479A5074463161 @default.
- W2403661479 hasConcept C121608353 @default.
- W2403661479 hasConcept C126322002 @default.
- W2403661479 hasConcept C185592680 @default.
- W2403661479 hasConcept C2777292972 @default.
- W2403661479 hasConcept C2777511904 @default.
- W2403661479 hasConcept C2777899217 @default.
- W2403661479 hasConcept C2779723316 @default.
- W2403661479 hasConcept C2780192828 @default.
- W2403661479 hasConcept C2781190966 @default.
- W2403661479 hasConcept C502942594 @default.
- W2403661479 hasConcept C530470458 @default.
- W2403661479 hasConcept C61367390 @default.
- W2403661479 hasConcept C71924100 @default.
- W2403661479 hasConcept C86803240 @default.
- W2403661479 hasConceptScore W2403661479C121608353 @default.
- W2403661479 hasConceptScore W2403661479C126322002 @default.
- W2403661479 hasConceptScore W2403661479C185592680 @default.
- W2403661479 hasConceptScore W2403661479C2777292972 @default.
- W2403661479 hasConceptScore W2403661479C2777511904 @default.
- W2403661479 hasConceptScore W2403661479C2777899217 @default.
- W2403661479 hasConceptScore W2403661479C2779723316 @default.
- W2403661479 hasConceptScore W2403661479C2780192828 @default.
- W2403661479 hasConceptScore W2403661479C2781190966 @default.
- W2403661479 hasConceptScore W2403661479C502942594 @default.
- W2403661479 hasConceptScore W2403661479C530470458 @default.
- W2403661479 hasConceptScore W2403661479C61367390 @default.
- W2403661479 hasConceptScore W2403661479C71924100 @default.
- W2403661479 hasConceptScore W2403661479C86803240 @default.
- W2403661479 hasLocation W24036614791 @default.
- W2403661479 hasOpenAccess W2403661479 @default.
- W2403661479 hasPrimaryLocation W24036614791 @default.
- W2403661479 hasRelatedWork W1028143 @default.
- W2403661479 hasRelatedWork W2606708 @default.
- W2403661479 hasRelatedWork W3847876 @default.
- W2403661479 hasRelatedWork W421584 @default.
- W2403661479 hasRelatedWork W5984520 @default.
- W2403661479 hasRelatedWork W6113875 @default.
- W2403661479 hasRelatedWork W6328432 @default.
- W2403661479 hasRelatedWork W7690840 @default.
- W2403661479 hasRelatedWork W8802154 @default.
- W2403661479 hasRelatedWork W9902881 @default.
- W2403661479 isParatext "false" @default.
- W2403661479 isRetracted "false" @default.
- W2403661479 magId "2403661479" @default.
- W2403661479 workType "article" @default.