Matches in SemOpenAlex for { <https://semopenalex.org/work/W2403669260> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2403669260 endingPage "H533" @default.
- W2403669260 startingPage "H526" @default.
- W2403669260 abstract "Hearts hypertrophied by pressure-overload are more susceptible to ischemia than nonhypertrophied hearts, which may result from the attenuation of self-protective responses. Because heat shock proteins (HSPs) are reported to protect against ischemic injuries, we hypothesized that HSP expression by coronary occlusion may be attenuated in hypertrophied hearts. We banded the ascending aorta to develop ventricular hypertrophy and put a snare around the left coronary artery in rats. After 4 wk, coronary occlusion was applied by tightening the snare for 5 or 10 min in rats with and without aortic banding. The hearts were excised 0, 0.5, 1, 2, 4, 8, 12, and 24 h after coronary occlusion. Ischemic and nonischemic myocardial tissues were obtained after the snare was tightly tied, and dye was infused from the aorta. The mRNAs and protein of 72-kDa HSP (HSP 72) and/or 73-kDa HSP (HSP 73) were detected by Northern and Western blot analyses. Protein and mRNA levels of HSPs expressed by 5-min coronary occlusion in hypertrophied hearts (left ventricular weight, 577 +/- 16 mg) were lower compared with those in control hearts (462 +/- 9 mg). A longer period of coronary occlusion (10 min) elevated the attenuated expression to a level similar to that in control hearts. Treatment with an angiotensin-converting enzyme (ACE) inhibitor (cilazapril, 10-15 mg.kg(-1).day(-1)) for 4 wk preserved HSP mRNA expression even in hearts with ascending aortic banding. In hypertrophied hearts, HSP 72 and 73 expression by coronary occlusion was attenuated and was modulated by the duration of coronary occlusion and by ACE inhibitor treatment." @default.
- W2403669260 created "2016-06-24" @default.
- W2403669260 creator A5029121602 @default.
- W2403669260 creator A5034609263 @default.
- W2403669260 creator A5072735319 @default.
- W2403669260 creator A5089878262 @default.
- W2403669260 date "1997-08-01" @default.
- W2403669260 modified "2023-09-27" @default.
- W2403669260 title "Attenuation of heat shock protein expression by coronary occlusion in hypertrophied hearts" @default.
- W2403669260 doi "https://doi.org/10.1152/ajpheart.1997.273.2.h526" @default.
- W2403669260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9277465" @default.
- W2403669260 hasPublicationYear "1997" @default.
- W2403669260 type Work @default.
- W2403669260 sameAs 2403669260 @default.
- W2403669260 citedByCount "6" @default.
- W2403669260 crossrefType "journal-article" @default.
- W2403669260 hasAuthorship W2403669260A5029121602 @default.
- W2403669260 hasAuthorship W2403669260A5034609263 @default.
- W2403669260 hasAuthorship W2403669260A5072735319 @default.
- W2403669260 hasAuthorship W2403669260A5089878262 @default.
- W2403669260 hasConcept C104317684 @default.
- W2403669260 hasConcept C126322002 @default.
- W2403669260 hasConcept C134018914 @default.
- W2403669260 hasConcept C164705383 @default.
- W2403669260 hasConcept C167414201 @default.
- W2403669260 hasConcept C185592680 @default.
- W2403669260 hasConcept C205260736 @default.
- W2403669260 hasConcept C2776268601 @default.
- W2403669260 hasConcept C2778249958 @default.
- W2403669260 hasConcept C2779980429 @default.
- W2403669260 hasConcept C2780393670 @default.
- W2403669260 hasConcept C541997718 @default.
- W2403669260 hasConcept C55493867 @default.
- W2403669260 hasConcept C71924100 @default.
- W2403669260 hasConceptScore W2403669260C104317684 @default.
- W2403669260 hasConceptScore W2403669260C126322002 @default.
- W2403669260 hasConceptScore W2403669260C134018914 @default.
- W2403669260 hasConceptScore W2403669260C164705383 @default.
- W2403669260 hasConceptScore W2403669260C167414201 @default.
- W2403669260 hasConceptScore W2403669260C185592680 @default.
- W2403669260 hasConceptScore W2403669260C205260736 @default.
- W2403669260 hasConceptScore W2403669260C2776268601 @default.
- W2403669260 hasConceptScore W2403669260C2778249958 @default.
- W2403669260 hasConceptScore W2403669260C2779980429 @default.
- W2403669260 hasConceptScore W2403669260C2780393670 @default.
- W2403669260 hasConceptScore W2403669260C541997718 @default.
- W2403669260 hasConceptScore W2403669260C55493867 @default.
- W2403669260 hasConceptScore W2403669260C71924100 @default.
- W2403669260 hasIssue "2" @default.
- W2403669260 hasLocation W24036692601 @default.
- W2403669260 hasLocation W24036692602 @default.
- W2403669260 hasOpenAccess W2403669260 @default.
- W2403669260 hasPrimaryLocation W24036692601 @default.
- W2403669260 hasRelatedWork W1514902666 @default.
- W2403669260 hasRelatedWork W1779480512 @default.
- W2403669260 hasRelatedWork W1981654342 @default.
- W2403669260 hasRelatedWork W1993394218 @default.
- W2403669260 hasRelatedWork W1993774701 @default.
- W2403669260 hasRelatedWork W2002616541 @default.
- W2403669260 hasRelatedWork W2021603989 @default.
- W2403669260 hasRelatedWork W2081636567 @default.
- W2403669260 hasRelatedWork W2091504832 @default.
- W2403669260 hasRelatedWork W2314941988 @default.
- W2403669260 hasVolume "273" @default.
- W2403669260 isParatext "false" @default.
- W2403669260 isRetracted "false" @default.
- W2403669260 magId "2403669260" @default.
- W2403669260 workType "article" @default.