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- W2403669321 abstract "Plasmapheresis was performed in dogs to change the serum protein and bile protein. A low caloric diet and plasmapheresis resulted in a diminished plasma albumin, slightly increased α-globulin, and definitely increased ß- and γ-globulins. Simultaneously, B-fraction (albumin-containing-fraction of bile) decreased while the C-fraction (α-globulin-containing-fraction of bile) and D-fraction (ß- and γ-globulin-containing-fraction of bile) increased. When the plasmapheresis was discontinued and a normal caloric diet supplied, there was a gradual reversal of these changes toward the original levels. This is further indication that B-, C- and D-fraction of bile proteins arise from blood proteins. It is apparent that this is not by simple transudation of proteins from capillaries to bile canaliculi because the smallest protein molecular B-fraction comprises a smaller proportion of bile proteins than of serum proteins, whereas the larger molecular D-fraction comprises a larger proportion of bile proteins than of serum proteins, and yet the total bile protein concentration is always much less than the total serum protein concentration. There must be some mechanism regulating the occurrence of the bile proteins, and this may be an additional function of the hepatic cells." @default.
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- W2403669321 date "1959-09-01" @default.
- W2403669321 modified "2023-09-26" @default.
- W2403669321 title "Influence of hypoproteinemia on bile proteins" @default.
- W2403669321 doi "https://doi.org/10.1152/ajplegacy.1959.197.3.558" @default.
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