Matches in SemOpenAlex for { <https://semopenalex.org/work/W2403669774> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W2403669774 endingPage "23" @default.
- W2403669774 startingPage "618" @default.
- W2403669774 abstract "Lipoprotein (a) is a relatively new independent risk factor of early atherosclerosis with atherogenic and thrombogenic properties. From the structural aspect it resembles LDL-lipoprotein and differs from the latter by the presence of another glycoprotein-apolipoprotein (a). Due to the great similarity of apolipoprotein (a) and plasminogen, lipoprotein (a) is bound to plasminogen receptors on the fibrin surface (fibrinogen) and thus prevents the cumulation and activation of local fibrinolysis. Its levels are under strict genetic control and are very little influenced by external factors and available hypolipidaemic treatment. There is a great interindividual variability of lipoprotein(a) concentrations which is due above all to the structural variability of apolipoprotein (a). At present at least 34 isoforms of apolipoprotein(a) were described which differ as to the size of the molecule. This great structural variability has an impact not only on the function and pathogenicity of lipoprotein (a) but also on methods of its assessment. High lipoprotein(a) concentrations are found in subjects with early clinical manifestations of atherosclerosis, in nephrotic syndrome, in chronic renal insufficiency, in haemodialyzed patients and other diseases. They rise in women after the menopause and are favourably influenced by hormonal substitution therapy. There is a number of immunochemical methods used for its estimation which are very well reproducible within the same laboratory. The high interlaboratory coefficients of variation indicate, however, that unification of lipoprotein(a) analyses is urgent." @default.
- W2403669774 created "2016-06-24" @default.
- W2403669774 creator A5027400640 @default.
- W2403669774 creator A5084174709 @default.
- W2403669774 date "1995-09-01" @default.
- W2403669774 modified "2023-09-23" @default.
- W2403669774 title "[Lipoprotein (a): a genetic risk factor with atherogenic and thrombogenic properties]." @default.
- W2403669774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7483354" @default.
- W2403669774 hasPublicationYear "1995" @default.
- W2403669774 type Work @default.
- W2403669774 sameAs 2403669774 @default.
- W2403669774 citedByCount "0" @default.
- W2403669774 crossrefType "journal-article" @default.
- W2403669774 hasAuthorship W2403669774A5027400640 @default.
- W2403669774 hasAuthorship W2403669774A5084174709 @default.
- W2403669774 hasConcept C126322002 @default.
- W2403669774 hasConcept C134018914 @default.
- W2403669774 hasConcept C2776104379 @default.
- W2403669774 hasConcept C2776825266 @default.
- W2403669774 hasConcept C2778163477 @default.
- W2403669774 hasConcept C2779036427 @default.
- W2403669774 hasConcept C2780072125 @default.
- W2403669774 hasConcept C62746215 @default.
- W2403669774 hasConcept C71924100 @default.
- W2403669774 hasConcept C86803240 @default.
- W2403669774 hasConceptScore W2403669774C126322002 @default.
- W2403669774 hasConceptScore W2403669774C134018914 @default.
- W2403669774 hasConceptScore W2403669774C2776104379 @default.
- W2403669774 hasConceptScore W2403669774C2776825266 @default.
- W2403669774 hasConceptScore W2403669774C2778163477 @default.
- W2403669774 hasConceptScore W2403669774C2779036427 @default.
- W2403669774 hasConceptScore W2403669774C2780072125 @default.
- W2403669774 hasConceptScore W2403669774C62746215 @default.
- W2403669774 hasConceptScore W2403669774C71924100 @default.
- W2403669774 hasConceptScore W2403669774C86803240 @default.
- W2403669774 hasIssue "9" @default.
- W2403669774 hasLocation W24036697741 @default.
- W2403669774 hasOpenAccess W2403669774 @default.
- W2403669774 hasPrimaryLocation W24036697741 @default.
- W2403669774 hasRelatedWork W1921887616 @default.
- W2403669774 hasRelatedWork W1984025014 @default.
- W2403669774 hasRelatedWork W2043222887 @default.
- W2403669774 hasRelatedWork W2073466768 @default.
- W2403669774 hasRelatedWork W2086757727 @default.
- W2403669774 hasRelatedWork W2109027187 @default.
- W2403669774 hasRelatedWork W2141642527 @default.
- W2403669774 hasRelatedWork W2151831271 @default.
- W2403669774 hasRelatedWork W2188061723 @default.
- W2403669774 hasRelatedWork W2413465750 @default.
- W2403669774 hasVolume "41" @default.
- W2403669774 isParatext "false" @default.
- W2403669774 isRetracted "false" @default.
- W2403669774 magId "2403669774" @default.
- W2403669774 workType "article" @default.