FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2403679905> ?p ?o ?g. }

• W2403679905 endingPage "7" @default.
• W2403679905 startingPage "62" @default.
• W2403679905 abstract "Diabetes mellitus (DM) is a chronic disease with a U.S. prevalence of 25.8 million, and 90-95% of all cases are type-2 diabetes mellitus (T2DM). Despite the known mortality and morbidity associated with T2DM, the majority of patients do not achieve their hemoglobin A1c (HbA1c) goals. Nonadherence is one of the contributing factors to the lackluster attainment of treatment goals. Drug tolerability may impact medication nonadherence; therefore, strategies to improve tolerability are important. Colesevelam, a second-generation bile acid resin, was designed with greater specificity and affinity for bile acids. Its physiochemical attributes contribute to an improved tolerability profile. Colesevelam has demonstrated efficacy in lowering HbA1c in addition to low-density lipoprotein-cholesterol, although clinical outcomes data are lacking. Several mechanisms of colesevelam's effect in T2DM have been proposed, including effects on insulin sensitivity and secretion, incretin effects, changes in bile acid composition, and splanchnic sequestration of mealtime glucose. Colesevelam is associated with reductions in HbA1c in T2DM patients ranging from 0.32 to 1.1 percentage points. Colesevelam is generally well tolerated, and indirect comparisons with cholestyramine suggest that it is associated with fewer gastrointestinal symptoms. Reported adherence and persistence to colesevelam treatment in observational studies are 33.3% and 49%, respectively." @default.
• W2403679905 created "2016-06-24" @default.
• W2403679905 creator A5003821899 @default.
• W2403679905 creator A5027328466 @default.
• W2403679905 date "2015-01-01" @default.
• W2403679905 modified "2023-09-23" @default.
• W2403679905 title "Patient tolerance and acceptance of colesevelam hydrochloride: focus on type-2 diabetes mellitus." @default.
• W2403679905 cites W1504151606 @default.
• W2403679905 cites W1968157528 @default.
• W2403679905 cites W1971627211 @default.
• W2403679905 cites W1977447015 @default.
• W2403679905 cites W1986971321 @default.
• W2403679905 cites W1987843898 @default.
• W2403679905 cites W1990008846 @default.
• W2403679905 cites W1992713447 @default.
• W2403679905 cites W1993940832 @default.
• W2403679905 cites W2001475834 @default.
• W2403679905 cites W2007869150 @default.
• W2403679905 cites W2009738913 @default.
• W2403679905 cites W2009802306 @default.
• W2403679905 cites W2010882273 @default.
• W2403679905 cites W2011054347 @default.
• W2403679905 cites W2017509671 @default.
• W2403679905 cites W2018104197 @default.
• W2403679905 cites W2020179045 @default.
• W2403679905 cites W2021042232 @default.
• W2403679905 cites W2021244274 @default.
• W2403679905 cites W2022113949 @default.
• W2403679905 cites W2029084557 @default.
• W2403679905 cites W2030721649 @default.
• W2403679905 cites W2032035573 @default.
• W2403679905 cites W2033045842 @default.
• W2403679905 cites W2033720203 @default.
• W2403679905 cites W2042444560 @default.
• W2403679905 cites W2043098959 @default.
• W2403679905 cites W2043961502 @default.
• W2403679905 cites W2045302557 @default.
• W2403679905 cites W2045362322 @default.
• W2403679905 cites W2046189497 @default.
• W2403679905 cites W205211558 @default.
• W2403679905 cites W2054983288 @default.
• W2403679905 cites W2057276238 @default.
• W2403679905 cites W2057913111 @default.
• W2403679905 cites W2060290335 @default.
• W2403679905 cites W2060839966 @default.
• W2403679905 cites W2062679938 @default.
• W2403679905 cites W2072979222 @default.
• W2403679905 cites W2073291685 @default.
• W2403679905 cites W2093375064 @default.
• W2403679905 cites W2094177994 @default.
• W2403679905 cites W2094381391 @default.
• W2403679905 cites W2099460952 @default.
• W2403679905 cites W2101244337 @default.
• W2403679905 cites W2112534505 @default.
• W2403679905 cites W2130189158 @default.
• W2403679905 cites W2130501785 @default.
• W2403679905 cites W2131105271 @default.
• W2403679905 cites W2132814611 @default.
• W2403679905 cites W2132848136 @default.
• W2403679905 cites W2134745997 @default.
• W2403679905 cites W2138109132 @default.
• W2403679905 cites W2141548864 @default.
• W2403679905 cites W2146901298 @default.
• W2403679905 cites W2147419557 @default.
• W2403679905 cites W2147494036 @default.
• W2403679905 cites W2155391879 @default.
• W2403679905 cites W2157454916 @default.
• W2403679905 cites W2164733897 @default.
• W2403679905 cites W2171109114 @default.
• W2403679905 cites W2172193326 @default.
• W2403679905 cites W2418104707 @default.
• W2403679905 cites W4229629337 @default.
• W2403679905 cites W4248021162 @default.
• W2403679905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4296594" @default.
• W2403679905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25628509" @default.
• W2403679905 hasPublicationYear "2015" @default.
• W2403679905 type Work @default.
• W2403679905 sameAs 2403679905 @default.
• W2403679905 citedByCount "1" @default.
• W2403679905 countsByYear W24036799052017 @default.
• W2403679905 crossrefType "journal-article" @default.
• W2403679905 hasAuthorship W2403679905A5003821899 @default.
• W2403679905 hasAuthorship W2403679905A5027328466 @default.
• W2403679905 hasConcept C126322002 @default.
• W2403679905 hasConcept C134018914 @default.
• W2403679905 hasConcept C197934379 @default.
• W2403679905 hasConcept C2777180221 @default.
• W2403679905 hasConcept C2778163477 @default.
• W2403679905 hasConcept C2778375690 @default.
• W2403679905 hasConcept C2778697171 @default.
• W2403679905 hasConcept C2778881409 @default.
• W2403679905 hasConcept C2779399885 @default.
• W2403679905 hasConcept C2910068830 @default.
• W2403679905 hasConcept C555293320 @default.
• W2403679905 hasConcept C71924100 @default.
• W2403679905 hasConcept C90924648 @default.
• W2403679905 hasConceptScore W2403679905C126322002 @default.
• W2403679905 hasConceptScore W2403679905C134018914 @default.

• next