Matches in SemOpenAlex for { <https://semopenalex.org/work/W2403686661> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2403686661 endingPage "40" @default.
- W2403686661 startingPage "33" @default.
- W2403686661 abstract "The effect of dietary fibers (DF) of wheat bran on hepatocyte apoptosis in rats adequately provided with vitamins or insufficiently supplied with vitamins has been investigated. 48 male Wistar rats (initial body mass--58.1 +/- 0.5 g) were randomly divided into 6 groups and fed with semi-synthetic diet, containing 100% or 20% of vitamin mixture (Vit) with or without addition of DF in the dose corresponding to the upper allowable level of its consumption (5% of diet mass) for 4 weeks. The animals of the 1 group received 100% of vitamin mixture (100% Vit); 2 group--100% Vit + DF; 3 group--20% of vitamin mixture with full exclusion of vitamins E, B1 and B2 (20% Vit); 4 group--20% of vitamin mixture and DF (20% Vit + DF). The next 5 days rats from vitamin-deficient groups were fed with diets supplemented with 80% of vitamins from their content in control group: (5 group--20% Vit + 80% Vit; 6 group--20% Vit + DF + 80% Vit). The suspension of hepatocytes was received by Becton Dickinson Medimachine System (USA). Hepatocyte apoptosis was assessed by the method of flow cytometry using Beckman Coulter FC 500 (USA) cytometer by stained cells with Annexin V-FITC/ 7-Amino-Actinomycin D Kit (Beckman Coulter, USA). In rats fed complete semi-synthetic diet supplemented with DF (100% Vit + DF) the hepatocyte apoptosis was higher by 22% (p < 0.10) than that in rats of control group (4.99 +/- 1.82%). In rats fed diets with low vitamin content (groups: 20% Vit and 20% Vit + DF) the hepatocyte apoptosis was significantly higher (p < 0.05) than that in the control group and reached 7.03 +/- 1.74 and 7.26 +/- 1.13% accordingly. Normalization of vitamin content in the diets of rats from deficient groups during 5 days had no effect on the severity of apoptosis regardless from presence (8.02 +/- 2.18%) or absence of the DF (8.04 +/- 1.66%). Adding DF in dose corresponding to the upper allowable level of consumption, on the background of adequate vitamin content in the diet is accompanied by a tendency to develop hepatocyte apoptosis, which may be the result of a direct action of short chain fatty acids generated from the DF and the deterioration of vitamin sufficiency." @default.
- W2403686661 created "2016-06-24" @default.
- W2403686661 creator A5004090993 @default.
- W2403686661 creator A5010418894 @default.
- W2403686661 creator A5056113629 @default.
- W2403686661 creator A5074076688 @default.
- W2403686661 creator A5077937934 @default.
- W2403686661 date "2014-01-01" @default.
- W2403686661 modified "2023-09-23" @default.
- W2403686661 title "[Effects of dietary fibers on hepatocyte apoptosis in rats with alimentary polyhypovitaminosis]." @default.
- W2403686661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25059054" @default.
- W2403686661 hasPublicationYear "2014" @default.
- W2403686661 type Work @default.
- W2403686661 sameAs 2403686661 @default.
- W2403686661 citedByCount "0" @default.
- W2403686661 crossrefType "journal-article" @default.
- W2403686661 hasAuthorship W2403686661A5004090993 @default.
- W2403686661 hasAuthorship W2403686661A5010418894 @default.
- W2403686661 hasAuthorship W2403686661A5056113629 @default.
- W2403686661 hasAuthorship W2403686661A5074076688 @default.
- W2403686661 hasAuthorship W2403686661A5077937934 @default.
- W2403686661 hasConcept C126322002 @default.
- W2403686661 hasConcept C134018914 @default.
- W2403686661 hasConcept C153911025 @default.
- W2403686661 hasConcept C178790620 @default.
- W2403686661 hasConcept C185592680 @default.
- W2403686661 hasConcept C190283241 @default.
- W2403686661 hasConcept C202751555 @default.
- W2403686661 hasConcept C206139338 @default.
- W2403686661 hasConcept C2776200302 @default.
- W2403686661 hasConcept C2776873940 @default.
- W2403686661 hasConcept C2776940978 @default.
- W2403686661 hasConcept C2777551382 @default.
- W2403686661 hasConcept C2778004101 @default.
- W2403686661 hasConcept C2780022331 @default.
- W2403686661 hasConcept C553184892 @default.
- W2403686661 hasConcept C55493867 @default.
- W2403686661 hasConcept C71924100 @default.
- W2403686661 hasConcept C86803240 @default.
- W2403686661 hasConcept C88634738 @default.
- W2403686661 hasConceptScore W2403686661C126322002 @default.
- W2403686661 hasConceptScore W2403686661C134018914 @default.
- W2403686661 hasConceptScore W2403686661C153911025 @default.
- W2403686661 hasConceptScore W2403686661C178790620 @default.
- W2403686661 hasConceptScore W2403686661C185592680 @default.
- W2403686661 hasConceptScore W2403686661C190283241 @default.
- W2403686661 hasConceptScore W2403686661C202751555 @default.
- W2403686661 hasConceptScore W2403686661C206139338 @default.
- W2403686661 hasConceptScore W2403686661C2776200302 @default.
- W2403686661 hasConceptScore W2403686661C2776873940 @default.
- W2403686661 hasConceptScore W2403686661C2776940978 @default.
- W2403686661 hasConceptScore W2403686661C2777551382 @default.
- W2403686661 hasConceptScore W2403686661C2778004101 @default.
- W2403686661 hasConceptScore W2403686661C2780022331 @default.
- W2403686661 hasConceptScore W2403686661C553184892 @default.
- W2403686661 hasConceptScore W2403686661C55493867 @default.
- W2403686661 hasConceptScore W2403686661C71924100 @default.
- W2403686661 hasConceptScore W2403686661C86803240 @default.
- W2403686661 hasConceptScore W2403686661C88634738 @default.
- W2403686661 hasIssue "1" @default.
- W2403686661 hasLocation W24036866611 @default.
- W2403686661 hasOpenAccess W2403686661 @default.
- W2403686661 hasPrimaryLocation W24036866611 @default.
- W2403686661 hasRelatedWork W1509699993 @default.
- W2403686661 hasRelatedWork W1963936565 @default.
- W2403686661 hasRelatedWork W2128584967 @default.
- W2403686661 hasRelatedWork W2368062056 @default.
- W2403686661 hasRelatedWork W2384075892 @default.
- W2403686661 hasRelatedWork W2393733452 @default.
- W2403686661 hasRelatedWork W2403686661 @default.
- W2403686661 hasRelatedWork W2411473202 @default.
- W2403686661 hasRelatedWork W2412660613 @default.
- W2403686661 hasRelatedWork W2415247795 @default.
- W2403686661 hasVolume "83" @default.
- W2403686661 isParatext "false" @default.
- W2403686661 isRetracted "false" @default.
- W2403686661 magId "2403686661" @default.
- W2403686661 workType "article" @default.