Matches in SemOpenAlex for { <https://semopenalex.org/work/W2403704191> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2403704191 endingPage "9" @default.
- W2403704191 startingPage "22" @default.
- W2403704191 abstract "Among Gram negative bacteria, Pseudomonas aeruginosa, the extended spectrum beta-lactamases (ESBL)-producing strains, Acinetobacter spp, in particular the multiresistant Acinetobacter baumannii, and Stenotrophomonas maltophilia are the most implicated micrororganisms in the ever more increasing problem of bacterial resistance. Possible solutions have to be searched, on one hand, in the use of new drugs but, on the other hand, in the re-evaluation of those already available drugs, possibly considering a new role for old drugs such as colistine and fosfomycin. Concerning ESBL-producing strains, the most recent data provided by EARSS report, in Italy, an incidence rate of 10-25 percent. The insurgence of an infection sustained by an ESBL+ve strain is strictly related to some well known risk factors, like the hospital stay itself, the disease severity, the length of stay in ICU, intubation and mechanical ventilation, catheterization, urinary or artery, and the past exposure to antibiotics. The raise in ESBL producing strains is closely related to the increasing use of cephalosporins. In the setting of a Gram negative infection, the combination therapy guarantees a higher coverage by reducing insurgence of possible resistance mechanisms, possibly resulting synergistic, and allowing a de-escalation therapy, although to this latter other problems, such as tolerability, costs and compliance, can be related. Another basic aspect to take into account of, in order to achieve the maximal efficacy of the antibiotic treatment, is the right dosage. In the idea to look for the best approach for the antibiotic treatment of a severe infection in a hospital setting, when a Gram negative aetiology is implicated, it can be possibly presumed that the right way consists in avoiding inappropriate antibiotic therapies, making therapeutic choices based on guidelines resulted from local epidemiological data, initiating the therapy promptly, avoiding excessive use of antibiotics, possibly modifying therapy at the light of clinical data and microbiological results (de-escalation)." @default.
- W2403704191 created "2016-06-24" @default.
- W2403704191 creator A5005642145 @default.
- W2403704191 creator A5039694085 @default.
- W2403704191 date "2008-04-01" @default.
- W2403704191 modified "2023-09-28" @default.
- W2403704191 title "[Diagnostic and therapeutic management of Gram-negative infections]." @default.
- W2403704191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18843221" @default.
- W2403704191 hasPublicationYear "2008" @default.
- W2403704191 type Work @default.
- W2403704191 sameAs 2403704191 @default.
- W2403704191 citedByCount "3" @default.
- W2403704191 countsByYear W24037041912012 @default.
- W2403704191 crossrefType "journal-article" @default.
- W2403704191 hasAuthorship W2403704191A5005642145 @default.
- W2403704191 hasAuthorship W2403704191A5039694085 @default.
- W2403704191 hasConcept C126322002 @default.
- W2403704191 hasConcept C177713679 @default.
- W2403704191 hasConcept C197934379 @default.
- W2403704191 hasConcept C2775941552 @default.
- W2403704191 hasConcept C2776315533 @default.
- W2403704191 hasConcept C2776352461 @default.
- W2403704191 hasConcept C2776685102 @default.
- W2403704191 hasConcept C2777637488 @default.
- W2403704191 hasConcept C2778375690 @default.
- W2403704191 hasConcept C2778523567 @default.
- W2403704191 hasConcept C2778897966 @default.
- W2403704191 hasConcept C501593827 @default.
- W2403704191 hasConcept C523546767 @default.
- W2403704191 hasConcept C54355233 @default.
- W2403704191 hasConcept C64778159 @default.
- W2403704191 hasConcept C71924100 @default.
- W2403704191 hasConcept C86803240 @default.
- W2403704191 hasConcept C89423630 @default.
- W2403704191 hasConcept C94665300 @default.
- W2403704191 hasConceptScore W2403704191C126322002 @default.
- W2403704191 hasConceptScore W2403704191C177713679 @default.
- W2403704191 hasConceptScore W2403704191C197934379 @default.
- W2403704191 hasConceptScore W2403704191C2775941552 @default.
- W2403704191 hasConceptScore W2403704191C2776315533 @default.
- W2403704191 hasConceptScore W2403704191C2776352461 @default.
- W2403704191 hasConceptScore W2403704191C2776685102 @default.
- W2403704191 hasConceptScore W2403704191C2777637488 @default.
- W2403704191 hasConceptScore W2403704191C2778375690 @default.
- W2403704191 hasConceptScore W2403704191C2778523567 @default.
- W2403704191 hasConceptScore W2403704191C2778897966 @default.
- W2403704191 hasConceptScore W2403704191C501593827 @default.
- W2403704191 hasConceptScore W2403704191C523546767 @default.
- W2403704191 hasConceptScore W2403704191C54355233 @default.
- W2403704191 hasConceptScore W2403704191C64778159 @default.
- W2403704191 hasConceptScore W2403704191C71924100 @default.
- W2403704191 hasConceptScore W2403704191C86803240 @default.
- W2403704191 hasConceptScore W2403704191C89423630 @default.
- W2403704191 hasConceptScore W2403704191C94665300 @default.
- W2403704191 hasLocation W24037041911 @default.
- W2403704191 hasOpenAccess W2403704191 @default.
- W2403704191 hasPrimaryLocation W24037041911 @default.
- W2403704191 hasRelatedWork W1963956238 @default.
- W2403704191 hasRelatedWork W1982600413 @default.
- W2403704191 hasRelatedWork W2018268645 @default.
- W2403704191 hasRelatedWork W2018548890 @default.
- W2403704191 hasRelatedWork W2034844309 @default.
- W2403704191 hasRelatedWork W2072713996 @default.
- W2403704191 hasRelatedWork W2079321216 @default.
- W2403704191 hasRelatedWork W2092409007 @default.
- W2403704191 hasRelatedWork W2143952244 @default.
- W2403704191 hasRelatedWork W2149075985 @default.
- W2403704191 hasRelatedWork W2171457888 @default.
- W2403704191 hasRelatedWork W2189503299 @default.
- W2403704191 hasRelatedWork W2212904326 @default.
- W2403704191 hasRelatedWork W2227004897 @default.
- W2403704191 hasRelatedWork W2301100232 @default.
- W2403704191 hasRelatedWork W2443195609 @default.
- W2403704191 hasRelatedWork W2536721813 @default.
- W2403704191 hasRelatedWork W2589280334 @default.
- W2403704191 hasRelatedWork W2621260729 @default.
- W2403704191 hasRelatedWork W2924739878 @default.
- W2403704191 hasVolume "16 Suppl2" @default.
- W2403704191 isParatext "false" @default.
- W2403704191 isRetracted "false" @default.
- W2403704191 magId "2403704191" @default.
- W2403704191 workType "article" @default.