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- W2403822990 abstract "The effect of various steroid contraceptive agents on the pituitary-gonadal system was studied in 8 women. Norethindrone inhibited the hypophyseal secretion of luteinizing hormone (LH) while megestrol acetate hastened LH release. Chlormadinone acetate appears to suppress ovulation by inhibiting the secretion of follicle stimulating hormone (FSH) or LH. Mestranol however primarily exerts its effect by inhibiting the release of FSH. Ovulation was induced in 2 women with secondary amenorrhea by the combined administration of human menstrual gonadotropin and human chorionic gonadotropin (HCG). Pregnant mares serum and HGC administered in combination induced ovulation in 2 of 3 normally menstruating women who were taking gestagens but the results with HCG alone were poor. Histological examination of ovarian sections revealed thickening of the tunica albuginea an increase in atretic follicles mild to moderate thecal luteinization and fibrosis of the stroma in all cases. The variations in actions of the steroids seem to be related to some extent to the pattern of urinary excretion of gonadotropin." @default.
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- W2403822990 date "1972-06-01" @default.
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- W2403822990 title "The kinetics of the human pituitary-gonadal system during steroid treatment." @default.
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