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- W2403842938 abstract "An in vitro assay has been applied in 23 patients with renal cell carcinoma. A mononuclear cell-rich fraction was cultured from peripheral blood of patients with renal cell carcinoma. The number of monocytes maturing into macrophages was quantitated over a period of 7 days. Monocyte maturation was significantly lower in patients with renal cell carcinoma than in normal individuals. Of 10 patients tested both pre- and post-nephrectomy, 8 patients showed clinical improvement after surgery. In all 8, the posttreatment macrophage yield improved significantly from the pretreatment values to approach normal values. In 2 patients found to have metastasis postoperatively, the macrophage yield continued below normal levels. Our results suggest that the in vitro maturation of macrophages from mononuclear cells may parallel clinical events." @default.
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- W2403842938 date "1983-09-01" @default.
- W2403842938 modified "2023-09-26" @default.
- W2403842938 title "Culture of Peripheral Monocytes in Vitro in Patients with Renal Cell Carcinoma: A Possible Prognostic Indicator" @default.
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- W2403842938 doi "https://doi.org/10.1016/s0022-5347(17)51321-x" @default.
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