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- W2403886552 endingPage "81" @default.
- W2403886552 startingPage "75" @default.
- W2403886552 abstract "Axon initial segment (AIS) is the proximal part of the axon, which is not covered with a myelin sheath and possesses a distinctive, specialized assembly of voltage-gated ion channels and associated proteins. AIS plays critical roles in synaptic integration and action potential generation in central neurons. Recent evidence shows that stroke causes rapid, irreversible calpain-mediated proteolysis of the AIS cytoskeleton of neurons surrounding the ischemic necrotic core. A better understanding of the molecular mechanisms underlying this non-lethal neuronal damage might provide new therapeutic strategies for improving stroke outcome. Here, we present a brief overview of the structure and function of the AIS. We then discuss possible mechanisms underlying stroke-induced AIS damage, including the roles of calpains and possible sources of Ca(2+) ions, which are necessary for the activation of calpains. Finally, we discuss the potential functional implications of the loss of the AIS cytoskeleton and ion channel clusters for neuronal excitability." @default.
- W2403886552 created "2016-06-24" @default.
- W2403886552 creator A5001854767 @default.
- W2403886552 creator A5070402908 @default.
- W2403886552 date "2015-12-21" @default.
- W2403886552 modified "2023-10-03" @default.
- W2403886552 title "Functional implications of axon initial segment cytoskeletal disruption in stroke" @default.
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