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• W2404008088 abstract "Influenza A virus (IAV) is a segmented negative-sense RNA virus that causes seasonal epidemics and periodic pandemics in humans. Two regions (nucleotide positions 82–148 and 497–564) in the positive-sense RNA of the NS segment fold into a multi-branch loop or hairpin structures. We studied 25,384 NS segment positive-sense RNA unique sequences of human and non-human IAVs in order to predict secondary RNA structures of the 82–148 and 497–564 regions using RNAfold software, and determined their host- and lineage-specific distributions. Hairpins prevailed in avian and avian-origin human IAVs, including H1N1pdm1918 and H5N1. In human and swine IAV hairpins distribution varied between evolutionary lineages. These results suggest a possible functional role for these RNA secondary structures and the need for experimental evaluation of these structures in the influenza life cycle." @default.
• W2404008088 created "2016-06-24" @default.
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• W2404008088 date "2016-05-20" @default.
• W2404008088 modified "2023-10-09" @default.
• W2404008088 title "The influenza A virus NS genome segment displays lineage-specific patterns in predicted RNA secondary structure" @default.
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• W2404008088 doi "https://doi.org/10.1186/s13104-016-2083-6" @default.
• W2404008088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4875733" @default.
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• W2404008088 hasPublicationYear "2016" @default.
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