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• W2404046659 startingPage "1163" @default.
• W2404046659 abstract "Introduction: Autoimmune hepatitis (AIH) is a severe life-threatening hepatopathy of unknown etiology, affecting both pediatric and adult populations, and characterised by inflammatory liver histology, circulating non-organ-specific autoantibodies, and hypergammaglobulinaemia. AIH is a very heterogeneous disease with a variety of clinical presentations, ranging from asymptomatic liver test abnormalities to acute severe hepatitis or even acute liver failure. It responds very well to immunosuppressive treatment with prednisolone with or without azathioprine. Patients who are intolerant or fail to respond to standard therapy are candidates for alternative immunosuppressive regimens, the combination of steroids with mycophenolate mofetil or calcineurin inhibitors being the most frequently reported. The pathogenesis of AIH remains not completely understood, although there is evidence that genetic predisposition, molecular mimicry and defective immunoregulatory mechanisms contribute to the autoimmune liver damage.Areas covered: A literature search was conducted using the key-words ‘autoimmune hepatitis’, ‘immunogenetics’, ‘regulatory T-cells’ and ‘immunosuppression’. The aim of this review is to discuss recent breakthroughs in the understanding AIH pathogenesis, diagnosis and treatment.Expert commentary: Progress in the understanding of AIH pathogenesis is likely to contribute to the development of novel therapeutic strategies, such as the adoptive transfer of autologous expanded antigen-specific regulatory T-cells." @default.
• W2404046659 created "2016-06-24" @default.
• W2404046659 creator A5002061253 @default.
• W2404046659 creator A5046470723 @default.
• W2404046659 creator A5068523462 @default.
• W2404046659 date "2016-06-03" @default.
• W2404046659 modified "2023-10-18" @default.
• W2404046659 title "Contemporary issues and future directions in autoimmune hepatitis" @default.
• W2404046659 cites W1454028175 @default.
• W2404046659 cites W1485643592 @default.
• W2404046659 cites W1498948971 @default.
• W2404046659 cites W1518082296 @default.
• W2404046659 cites W1559193604 @default.
• W2404046659 cites W1613711713 @default.
• W2404046659 cites W1862847840 @default.
• W2404046659 cites W1916127359 @default.
• W2404046659 cites W1964062013 @default.
• W2404046659 cites W1965572636 @default.
• W2404046659 cites W1966490902 @default.
• W2404046659 cites W1969917809 @default.
• W2404046659 cites W1970535089 @default.
• W2404046659 cites W1971668390 @default.
• W2404046659 cites W1973130325 @default.
• W2404046659 cites W1973339766 @default.
• W2404046659 cites W1973849425 @default.
• W2404046659 cites W1976054841 @default.
• W2404046659 cites W1977878136 @default.
• W2404046659 cites W1980062656 @default.
• W2404046659 cites W1980921578 @default.
• W2404046659 cites W1981536745 @default.
• W2404046659 cites W1982288970 @default.
• W2404046659 cites W1984419953 @default.
• W2404046659 cites W1987144168 @default.
• W2404046659 cites W1992915371 @default.
• W2404046659 cites W1997647425 @default.
• W2404046659 cites W1997982558 @default.
• W2404046659 cites W1998949806 @default.
• W2404046659 cites W1999672624 @default.
• W2404046659 cites W1999980623 @default.
• W2404046659 cites W2000484633 @default.
• W2404046659 cites W2000959749 @default.
• W2404046659 cites W2001123056 @default.
• W2404046659 cites W2002828005 @default.
• W2404046659 cites W2003353479 @default.
• W2404046659 cites W2003655939 @default.
• W2404046659 cites W2004003332 @default.
• W2404046659 cites W2006493179 @default.
• W2404046659 cites W2007142217 @default.
• W2404046659 cites W2008658190 @default.
• W2404046659 cites W2009184780 @default.
• W2404046659 cites W2009415077 @default.
• W2404046659 cites W2009522235 @default.
• W2404046659 cites W2012941212 @default.
• W2404046659 cites W2013648656 @default.
• W2404046659 cites W2017419353 @default.
• W2404046659 cites W2019080866 @default.
• W2404046659 cites W2021234462 @default.
• W2404046659 cites W2021815290 @default.
• W2404046659 cites W2022202791 @default.
• W2404046659 cites W2024490058 @default.
• W2404046659 cites W2026784146 @default.
• W2404046659 cites W2027752385 @default.
• W2404046659 cites W2030973449 @default.
• W2404046659 cites W2034288342 @default.
• W2404046659 cites W2037296823 @default.
• W2404046659 cites W2039049566 @default.
• W2404046659 cites W2040423355 @default.
• W2404046659 cites W2041914872 @default.
• W2404046659 cites W2042142548 @default.
• W2404046659 cites W2047989729 @default.
• W2404046659 cites W2049587621 @default.
• W2404046659 cites W2052425971 @default.
• W2404046659 cites W2052482860 @default.
• W2404046659 cites W2052589536 @default.
• W2404046659 cites W2055202209 @default.
• W2404046659 cites W2056051783 @default.
• W2404046659 cites W2058957121 @default.
• W2404046659 cites W2064389502 @default.
• W2404046659 cites W2064477316 @default.
• W2404046659 cites W2065338991 @default.
• W2404046659 cites W2068373868 @default.
• W2404046659 cites W2068639447 @default.
• W2404046659 cites W2069308616 @default.
• W2404046659 cites W2071553791 @default.
• W2404046659 cites W2074504038 @default.
• W2404046659 cites W2076839204 @default.
• W2404046659 cites W2085106134 @default.
• W2404046659 cites W2086030126 @default.
• W2404046659 cites W2087797638 @default.
• W2404046659 cites W2087850939 @default.
• W2404046659 cites W2090069133 @default.
• W2404046659 cites W2090645357 @default.
• W2404046659 cites W2091218470 @default.
• W2404046659 cites W2092696659 @default.
• W2404046659 cites W2095262005 @default.
• W2404046659 cites W2095607675 @default.
• W2404046659 cites W2095937258 @default.
• W2404046659 cites W2106268478 @default.

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