FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2404095905> ?p ?o ?g. }

• W2404095905 endingPage "65" @default.
• W2404095905 startingPage "449" @default.
• W2404095905 abstract "Peripheral blood lymphocytes of twenty-three subjects with grass pollen allergy were cultured with grass pollen antigen for 3 days. After harvesting, the culture supernatants were added to fresh autologous lymphocytes which were maintained in culture for 6 days. Cellular uptake of [3H]thymidine was measured during the sixth day of culture, and revealed that the lymphocyte culture supernatants stimulated greater thymidine uptake than expected from the lymphocyte transformation response to corresponding amounts of antigen. The supernatant factor which mediated this effect was termed `lymphocyte mitogenic factor' by analogy with a similar response of lymphocytes in clinical and experimental delayed hypersensitivity. Lymphocyte culture supernatants were also tested for migration–inhibition factor by their ability to inhibit the migration of guinea-pig macrophages.The majority of `allergic' supernatants contained a lymphocyte mitogenic factor active at 1/3 dilution (14/22) and 1/12 dilution (19/21) in contrast to supernatants derived from non-allergic subjects (2/16 and 1/17 respectively). The production of lymphocyte mitogenic factor corresponded to the occurrence of antigen-induced lymphocyte transformation (allergic: 18/22; non-allergic: 1/14); but only a minority of allergic supernatants contained a migration–inhibition factor (6/20). Clinical analysis revealed that migration–inhibition factor was particularly associated with the milder forms of allergy and with a past history of desensitization by depot injection of emulsified pollen antigen. In contrast, lymphocyte transformation and the production of mitogenic factor were uniformly distributed among the various categories of allergic subjects, all of whom had immediate (reaginic) hypersensitivity, but only three of whom had delayed hypersensitivity.The demonstration of lymphocyte mitogenic factor in a clinical state dominated by immediate hypersensitivity supported the view that antigen-induced transformations are generally mediated by soluble `mitogenic' factors and that such mediators are not necessarily identical to those which can inhibit macrophage migration. It appeared that some features of cellular immunity were associated with grass pollen allergy, in which it is suggested that heterogeneity of lymphocyte-derived mediators may underlie an apparent dissociation of cellular immune functions. On this basis it is proposed that clinical expression of an atopic state may be partly governed by which features of cellular immunity are present." @default.
• W2404095905 created "2016-06-24" @default.
• W2404095905 creator A5009969782 @default.
• W2404095905 creator A5024393556 @default.
• W2404095905 creator A5028810204 @default.
• W2404095905 creator A5039570752 @default.
• W2404095905 creator A5060926122 @default.
• W2404095905 date "1971-10-01" @default.
• W2404095905 modified "2023-09-26" @default.
• W2404095905 title "The production of lymphocyte mitogenic factor and migration-inhibition factor by antigen-stimulated lymphocytes of subjects with grass pollen allergy." @default.
• W2404095905 cites W1966219334 @default.
• W2404095905 cites W1967918330 @default.
• W2404095905 cites W1978753367 @default.
• W2404095905 cites W1987885307 @default.
• W2404095905 cites W1993730275 @default.
• W2404095905 cites W1994754374 @default.
• W2404095905 cites W1999213780 @default.
• W2404095905 cites W1999285365 @default.
• W2404095905 cites W2039303658 @default.
• W2404095905 cites W204990868 @default.
• W2404095905 cites W2069357264 @default.
• W2404095905 cites W2074202544 @default.
• W2404095905 cites W2086648020 @default.
• W2404095905 cites W2097511541 @default.
• W2404095905 cites W2415112390 @default.
• W2404095905 cites W2415182244 @default.
• W2404095905 cites W2441371252 @default.
• W2404095905 cites W1619941175 @default.
• W2404095905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1713015" @default.
• W2404095905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5123223" @default.
• W2404095905 hasPublicationYear "1971" @default.
• W2404095905 type Work @default.
• W2404095905 sameAs 2404095905 @default.
• W2404095905 citedByCount "20" @default.
• W2404095905 crossrefType "journal-article" @default.
• W2404095905 hasAuthorship W2404095905A5009969782 @default.
• W2404095905 hasAuthorship W2404095905A5024393556 @default.
• W2404095905 hasAuthorship W2404095905A5028810204 @default.
• W2404095905 hasAuthorship W2404095905A5039570752 @default.
• W2404095905 hasAuthorship W2404095905A5060926122 @default.
• W2404095905 hasConcept C147483822 @default.
• W2404095905 hasConcept C203014093 @default.
• W2404095905 hasConcept C207480886 @default.
• W2404095905 hasConcept C2777761686 @default.
• W2404095905 hasConcept C2992881475 @default.
• W2404095905 hasConcept C86803240 @default.
• W2404095905 hasConceptScore W2404095905C147483822 @default.
• W2404095905 hasConceptScore W2404095905C203014093 @default.
• W2404095905 hasConceptScore W2404095905C207480886 @default.
• W2404095905 hasConceptScore W2404095905C2777761686 @default.
• W2404095905 hasConceptScore W2404095905C2992881475 @default.
• W2404095905 hasConceptScore W2404095905C86803240 @default.
• W2404095905 hasIssue "4" @default.
• W2404095905 hasLocation W24040959051 @default.
• W2404095905 hasOpenAccess W2404095905 @default.
• W2404095905 hasPrimaryLocation W24040959051 @default.
• W2404095905 hasRelatedWork W1970167721 @default.
• W2404095905 hasRelatedWork W1975126408 @default.
• W2404095905 hasRelatedWork W1978625028 @default.
• W2404095905 hasRelatedWork W1980051361 @default.
• W2404095905 hasRelatedWork W2004039983 @default.
• W2404095905 hasRelatedWork W2076202779 @default.
• W2404095905 hasRelatedWork W2149871822 @default.
• W2404095905 hasRelatedWork W2156948268 @default.
• W2404095905 hasRelatedWork W2417789235 @default.
• W2404095905 hasRelatedWork W339222716 @default.
• W2404095905 hasVolume "9" @default.
• W2404095905 isParatext "false" @default.
• W2404095905 isRetracted "false" @default.
• W2404095905 magId "2404095905" @default.
• W2404095905 workType "article" @default.