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• W2404182134 endingPage "e0153102" @default.
• W2404182134 startingPage "e0153102" @default.
• W2404182134 abstract "We investigated the distinctiveness of gene regulatory networks in CA1 associated with the extinction of contextual fear memory (CFM) after recall using Affymetrix GeneChip Rat Genome 230 2.0 Arrays. These data were compared to previously published retrieval and reconsolidation-attributed, and consolidation datasets. A stringent dual normalization and pareto-scaled orthogonal partial least-square discriminant multivariate analysis together with a jack-knifing-based cross-validation approach was used on all datasets to reduce false positives. Consolidation, retrieval and extinction were correlated with distinct patterns of gene expression 2 hours later. Extinction-related gene expression was most distinct from the profile accompanying consolidation. A highly specific feature was the discrete regulation of neuroimmunological gene expression associated with retrieval and extinction. Immunity–associated genes of the tyrosine kinase receptor TGFβ and PDGF, and TNF families’ characterized extinction. Cytokines and proinflammatory interleukins of the IL-1 and IL-6 families were enriched with the no-extinction retrieval condition. We used comparative genomics to predict transcription factor binding sites in proximal promoter regions of the retrieval-regulated genes. Retrieval that does not lead to extinction was associated with NF-κB-mediated gene expression. We confirmed differential NF-κBp65 expression, and activity in all of a representative sample of our candidate genes in the no-extinction condition. The differential regulation of cytokine networks after the acquisition and retrieval of CFM identifies the important contribution that neuroimmune signalling plays in normal hippocampal function. Further, targeting cytokine signalling upon retrieval offers a therapeutic strategy to promote extinction mechanisms in human disorders characterised by dysregulation of associative memory." @default.
• W2404182134 created "2016-06-24" @default.
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• W2404182134 date "2016-05-25" @default.
• W2404182134 modified "2023-09-23" @default.
• W2404182134 title "The Regulation of Cytokine Networks in Hippocampal CA1 Differentiates Extinction from Those Required for the Maintenance of Contextual Fear Memory after Recall" @default.
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• W2404182134 cites W1963651954 @default.
• W2404182134 cites W1972758800 @default.
• W2404182134 cites W1974491267 @default.
• W2404182134 cites W1987874272 @default.
• W2404182134 cites W1989041973 @default.
• W2404182134 cites W1989085266 @default.
• W2404182134 cites W1990993711 @default.
• W2404182134 cites W1991021935 @default.
• W2404182134 cites W2002459043 @default.
• W2404182134 cites W2004232360 @default.
• W2404182134 cites W2009138589 @default.
• W2404182134 cites W2011180367 @default.
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• W2404182134 cites W2078758148 @default.
• W2404182134 cites W2080359823 @default.
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• W2404182134 doi "https://doi.org/10.1371/journal.pone.0153102" @default.
• W2404182134 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4880201" @default.
• W2404182134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27224427" @default.
• W2404182134 hasPublicationYear "2016" @default.
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