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- W2404183265 abstract "巨噬细胞(macrophages)是一种几乎分布于机体所有组织的吞噬细胞.当外界病原菌侵入机体的无菌环境时,它通过识别摄取、抗原呈递等作用吞噬杀灭病原菌,并能够释放炎症介质等调节适应性免疫.由此可见,巨噬细胞不仅是固有免疫中的主力军,还是连接固有免疫和适应性免疫的桥梁.脓毒症是一种涉及固有免疫和适应性免疫反应的复杂综合征,探讨脓毒症发生发展过程中巨噬细胞的来源分化及功能显得尤为重要,本文中将对巨噬细胞在脓毒症发病机制中的作用研究动态进行综述.1 巨噬细胞概述单核/巨噬细胞系统(mononuclear phagocytic system)由骨髓干细胞髓系分化而来.骨髓中髓系前体细胞被释放到血液循环中形成单核细胞,并在数天内分布于全身组织,形成不成熟单核细胞的储存库.当单核细胞从血液循环中迁移溢出,并分化成为巨噬细胞或髓系树突细胞(DC)时,全身组织中储存的单核细胞便会进来补充.换言之,单核细胞即是巨噬细胞和DC细胞在稳态期应对炎症反应的后备储存库[1]。" @default.
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- W2404183265 date "2013-04-01" @default.
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- W2404183265 title "[Advance in the study of the role of macrophages in the pathogenesis of sepsis]." @default.
- W2404183265 doi "https://doi.org/10.3760/cma.j.issn.2095-4352.2013.04.020" @default.
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