FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2404241327> ?p ?o ?g. }

• W2404241327 abstract "Abstract Abstract 2286 Poster Board II-263 Background: The outcomes of related and unrelated donor hematopoietic stem cell transplantations (HSCT) are strongly affected by the degree of human leukocyte antigen (HLA) matching between the transplant recipient and the donor or cord blood unit. HLA matching plays an important role in engraftment, incidence and severity of graft-versus-host disease (GVHD) and also in overall survival; although this factor is still not validated yet in many hematological malignancies. Objective: To evaluate the impact of HLA matching and difference in matching degree among transplants from unrelated donors (UD) on different outcomes in chronic lymphocytic leukemia (CLL). Materials & methods: We have analyzed 370 CLL patients who underwent an allogeneic HSCT reported to the EBMT registry. There were 280 males (75%) and 90 females with a median age of 53 years (24-69). Forty-five patients (12%) have received a previous HSCT. At transplant, 294 among 317 evaluated patients had a good performance status (PS) (93%), 43 patients were in CR (12%), 160 in PR (46%), 44 in SD (13%) and 103 in PD (29%) among 349 evaluated patients. Two hundred and sixty six patients received a reduced intensity conditioning regimen (RIC) and 103 a standard (Std) conditioning; 313 patients received PBSC, 56 BM and 2 cord blood cells from 198 HLA siblings, and 172 unrelated donors (UD). There were 136 (36%) sex-mismatched (91 F/M and 45 M/F), 150 pairs (40%) had an ABO incompatibility (61 minor, 89 major) and for CMV: 78 pairs were +, 146 - and 111 mixed. The median interval between diagnosis and transplantation was 53 months (3-308). According to the registry, there were 198 HLA siblings, 135 matched UD (MUD) and 37 mismatched UD (MMUD). We focused on UD and re-analyzed all HLA typings for patients and donors, after classification we found: 24 well matched (10/10 in high resolution), 28 partially matched (7/7, 8/8 or 9/9 in high resolution), 30 matched in low resolution and 90 mismatched in high resolution, which was different from the registry classification. Results: After transplantation, 359 patients engrafted, 199 developed an AGVHD (gr I: 74, gr II: 79, gr III: 29 and gr IV: 17) and 171 presented a cGVHD (83 limited and 88 extensive). The cumulative incidence of AGVHD for the total population was 22% for gr II and 13% for gr > II. [Siblings: 19% and 12%; well & patially matched: 37% and 10%; low resolution & MMUD: 19.6% and 15.3% for grII & gr > II respectively]. At 1 year after transplant for the total population, the cumulative incidence of limited and extensive cGVHD was 17 % (15-19) and 18.4% (16.4-20.4)[ Siblings: 16.2% (13.6-19) and 17.2% (14.5-20); well & patially matched: 23% (17.2-29) and 23.1% (17.2-29); low resolution & MMUD: 15.8% (12.3-19.1) and 18.3% (14.8-21.8)] respectively. With a median follow up of 48 months, the probability of 3 and 5-years overall survival (OS) for the total population were 62% (56-67) and 52% (45-57) respectively. We found a high significant difference in term of OS between the siblings, well & partially matched groups versus low & MMUD groups (p=0.002) (figure 2). [OS at 3 & 5 years; Siblings: 68.3% (61.8-75.5) and 57.2% (49.8-65.6); well & patially matched: 60.8% (47.6-77.7) and 53.3% (39.2-72.4), low resolution & MMUD: 49% (40.3-59.5) and 38.5% (29.5-50.2) respectively]. We observed also a high significant difference in term of transplant related mortality (TRM) between the same groups (p=0.0022) (figure 4). The multivariate analysis using Cox model studying age, pre-transplant status; gender, PS, cells source, ABO compatibility, conditioning and different HLA groups, showed a significant impact of 4 factors on OS: age: HR=1.04 (1.01-1.6) p=0.001, disease status (PD): HR=3.08 (1.2-7.1) p=0.02, PS: HR=2.37 (1.1-5.1) p=0.02 and HLA MMUD group: HR= 1.62 (1.02-2.59) p=0.03. The same factors were also highly significant in multivariate analysis in term of TRM (age: HR=1.04 (1.001-1.07) p=0.009, disease status (PD): HR=5.49 (1.29-23.4) p=0.02, PS: HR=3.8 (1.7-8.4) p=0.01 and HLA MMUD group: HR= 1.9 (1.07-3.37) p=0.02. Conclusion: This large retrospective analysis pointed out the high impact of HLA matching in terms of OS and TRM (in addition of age, disease status and PS), without any difference between HLA siblings, MUD and partially matched groups. Moreover, we demonstrated the importance of HLA classification when registering patients in the EBMT registry and its impact on different outcomes. Disclosures: No relevant conflicts of interest to declare." @default.
• W2404241327 created "2016-06-24" @default.
• W2404241327 creator A5003455280 @default.
• W2404241327 creator A5005481013 @default.
• W2404241327 creator A5027302651 @default.
• W2404241327 creator A5031769736 @default.
• W2404241327 creator A5031825598 @default.
• W2404241327 creator A5034008882 @default.
• W2404241327 creator A5035489508 @default.
• W2404241327 creator A5037448560 @default.
• W2404241327 creator A5038427683 @default.
• W2404241327 creator A5042734609 @default.
• W2404241327 creator A5058677948 @default.
• W2404241327 creator A5062694494 @default.
• W2404241327 creator A5062839406 @default.
• W2404241327 creator A5072027146 @default.
• W2404241327 creator A5076329357 @default.
• W2404241327 creator A5076734375 @default.
• W2404241327 creator A5085132315 @default.
• W2404241327 creator A5085146093 @default.
• W2404241327 date "2009-11-20" @default.
• W2404241327 modified "2023-10-02" @default.
• W2404241327 title "High Impact of Human Leukocyte Antigen Matching On Overall Survival and Transplant Related Mortality in Allogeneic Hematopoietic Stem Cell Transplantation for CLL: Long-Term Study From the EBMT Registry." @default.
• W2404241327 doi "https://doi.org/10.1182/blood.v114.22.2286.2286" @default.
• W2404241327 hasPublicationYear "2009" @default.
• W2404241327 type Work @default.
• W2404241327 sameAs 2404241327 @default.
• W2404241327 citedByCount "0" @default.
• W2404241327 crossrefType "journal-article" @default.
• W2404241327 hasAuthorship W2404241327A5003455280 @default.
• W2404241327 hasAuthorship W2404241327A5005481013 @default.
• W2404241327 hasAuthorship W2404241327A5027302651 @default.
• W2404241327 hasAuthorship W2404241327A5031769736 @default.
• W2404241327 hasAuthorship W2404241327A5031825598 @default.
• W2404241327 hasAuthorship W2404241327A5034008882 @default.
• W2404241327 hasAuthorship W2404241327A5035489508 @default.
• W2404241327 hasAuthorship W2404241327A5037448560 @default.
• W2404241327 hasAuthorship W2404241327A5038427683 @default.
• W2404241327 hasAuthorship W2404241327A5042734609 @default.
• W2404241327 hasAuthorship W2404241327A5058677948 @default.
• W2404241327 hasAuthorship W2404241327A5062694494 @default.
• W2404241327 hasAuthorship W2404241327A5062839406 @default.
• W2404241327 hasAuthorship W2404241327A5072027146 @default.
• W2404241327 hasAuthorship W2404241327A5076329357 @default.
• W2404241327 hasAuthorship W2404241327A5076734375 @default.
• W2404241327 hasAuthorship W2404241327A5085132315 @default.
• W2404241327 hasAuthorship W2404241327A5085146093 @default.
• W2404241327 hasConcept C126322002 @default.
• W2404241327 hasConcept C141071460 @default.
• W2404241327 hasConcept C147483822 @default.
• W2404241327 hasConcept C176080213 @default.
• W2404241327 hasConcept C188280979 @default.
• W2404241327 hasConcept C203014093 @default.
• W2404241327 hasConcept C2777408962 @default.
• W2404241327 hasConcept C2779972918 @default.
• W2404241327 hasConcept C2780914630 @default.
• W2404241327 hasConcept C2911091166 @default.
• W2404241327 hasConcept C71924100 @default.
• W2404241327 hasConcept C90924648 @default.
• W2404241327 hasConceptScore W2404241327C126322002 @default.
• W2404241327 hasConceptScore W2404241327C141071460 @default.
• W2404241327 hasConceptScore W2404241327C147483822 @default.
• W2404241327 hasConceptScore W2404241327C176080213 @default.
• W2404241327 hasConceptScore W2404241327C188280979 @default.
• W2404241327 hasConceptScore W2404241327C203014093 @default.
• W2404241327 hasConceptScore W2404241327C2777408962 @default.
• W2404241327 hasConceptScore W2404241327C2779972918 @default.
• W2404241327 hasConceptScore W2404241327C2780914630 @default.
• W2404241327 hasConceptScore W2404241327C2911091166 @default.
• W2404241327 hasConceptScore W2404241327C71924100 @default.
• W2404241327 hasConceptScore W2404241327C90924648 @default.
• W2404241327 hasLocation W24042413271 @default.
• W2404241327 hasOpenAccess W2404241327 @default.
• W2404241327 hasPrimaryLocation W24042413271 @default.
• W2404241327 hasRelatedWork W2035523115 @default.
• W2404241327 hasRelatedWork W2058524254 @default.
• W2404241327 hasRelatedWork W2080252342 @default.
• W2404241327 hasRelatedWork W2338649718 @default.
• W2404241327 hasRelatedWork W2527154745 @default.
• W2404241327 hasRelatedWork W2545515351 @default.
• W2404241327 hasRelatedWork W2553661869 @default.
• W2404241327 hasRelatedWork W2555256262 @default.
• W2404241327 hasRelatedWork W2557237563 @default.
• W2404241327 hasRelatedWork W2563423704 @default.
• W2404241327 hasRelatedWork W2569580730 @default.
• W2404241327 hasRelatedWork W2573101281 @default.
• W2404241327 hasRelatedWork W2590289920 @default.
• W2404241327 hasRelatedWork W2591729942 @default.
• W2404241327 hasRelatedWork W2614476956 @default.
• W2404241327 hasRelatedWork W2751843345 @default.
• W2404241327 hasRelatedWork W2786688102 @default.
• W2404241327 hasRelatedWork W2979622763 @default.
• W2404241327 hasRelatedWork W3182771327 @default.
• W2404241327 hasRelatedWork W3186415996 @default.
• W2404241327 isParatext "false" @default.
• W2404241327 isRetracted "false" @default.
• W2404241327 magId "2404241327" @default.
• W2404241327 workType "article" @default.