Matches in SemOpenAlex for { <https://semopenalex.org/work/W2404291019> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2404291019 startingPage "124" @default.
- W2404291019 abstract "Protein kinase CKII is composed of two catalytic (alpha or alpha') subunits and two regulatory (beta) subunits. The beta subunit mediates tetramer formation through beta-beta homodimerization and alpha-beta heterodimerization. In a previous study R26 and R75, point mutants of CKIIb defective in beta-beta dimerization, were isolated. In the present work we characterized these CKIIbeta mutants in vitro. Purified R26 and R75 bound to CKIIalpha but were defective in binding to CKIIbeta. R75 stimulated the catalytic activity of CKII whereas R26 gave little stimulation, and poly-L-lysine increased the stimulation of catalytic activity by R26 or R75. Circular dichroism and intrinsic fluorescence data pointed to different conformational changes in R26 and R75. Molecular modeling of these mutants provides an explanation of the difference in their ability to interact with CKIIbeta and to activate CKIIalpha." @default.
- W2404291019 created "2016-06-24" @default.
- W2404291019 creator A5021983643 @default.
- W2404291019 creator A5032155136 @default.
- W2404291019 creator A5075150288 @default.
- W2404291019 creator A5090502997 @default.
- W2404291019 date "2005-02-28" @default.
- W2404291019 modified "2023-09-23" @default.
- W2404291019 title "In vitro characterization of protein kinase CKII beta mutants defective in beta-beta dimerization." @default.
- W2404291019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15750349" @default.
- W2404291019 hasPublicationYear "2005" @default.
- W2404291019 type Work @default.
- W2404291019 sameAs 2404291019 @default.
- W2404291019 citedByCount "0" @default.
- W2404291019 crossrefType "journal-article" @default.
- W2404291019 hasAuthorship W2404291019A5021983643 @default.
- W2404291019 hasAuthorship W2404291019A5032155136 @default.
- W2404291019 hasAuthorship W2404291019A5075150288 @default.
- W2404291019 hasAuthorship W2404291019A5090502997 @default.
- W2404291019 hasConcept C104292427 @default.
- W2404291019 hasConcept C104317684 @default.
- W2404291019 hasConcept C12554922 @default.
- W2404291019 hasConcept C143065580 @default.
- W2404291019 hasConcept C159110408 @default.
- W2404291019 hasConcept C185592680 @default.
- W2404291019 hasConcept C199360897 @default.
- W2404291019 hasConcept C2775944032 @default.
- W2404291019 hasConcept C2776174256 @default.
- W2404291019 hasConcept C41008148 @default.
- W2404291019 hasConcept C49453240 @default.
- W2404291019 hasConcept C55493867 @default.
- W2404291019 hasConcept C64943373 @default.
- W2404291019 hasConcept C71924100 @default.
- W2404291019 hasConcept C86803240 @default.
- W2404291019 hasConcept C95444343 @default.
- W2404291019 hasConceptScore W2404291019C104292427 @default.
- W2404291019 hasConceptScore W2404291019C104317684 @default.
- W2404291019 hasConceptScore W2404291019C12554922 @default.
- W2404291019 hasConceptScore W2404291019C143065580 @default.
- W2404291019 hasConceptScore W2404291019C159110408 @default.
- W2404291019 hasConceptScore W2404291019C185592680 @default.
- W2404291019 hasConceptScore W2404291019C199360897 @default.
- W2404291019 hasConceptScore W2404291019C2775944032 @default.
- W2404291019 hasConceptScore W2404291019C2776174256 @default.
- W2404291019 hasConceptScore W2404291019C41008148 @default.
- W2404291019 hasConceptScore W2404291019C49453240 @default.
- W2404291019 hasConceptScore W2404291019C55493867 @default.
- W2404291019 hasConceptScore W2404291019C64943373 @default.
- W2404291019 hasConceptScore W2404291019C71924100 @default.
- W2404291019 hasConceptScore W2404291019C86803240 @default.
- W2404291019 hasConceptScore W2404291019C95444343 @default.
- W2404291019 hasIssue "1" @default.
- W2404291019 hasLocation W24042910191 @default.
- W2404291019 hasLocation W24042910192 @default.
- W2404291019 hasOpenAccess W2404291019 @default.
- W2404291019 hasPrimaryLocation W24042910191 @default.
- W2404291019 hasRelatedWork W1495640495 @default.
- W2404291019 hasRelatedWork W1535803112 @default.
- W2404291019 hasRelatedWork W1548525708 @default.
- W2404291019 hasRelatedWork W1556727056 @default.
- W2404291019 hasRelatedWork W1565199479 @default.
- W2404291019 hasRelatedWork W1569246897 @default.
- W2404291019 hasRelatedWork W1577006617 @default.
- W2404291019 hasRelatedWork W1965021832 @default.
- W2404291019 hasRelatedWork W2005012362 @default.
- W2404291019 hasRelatedWork W2012871985 @default.
- W2404291019 hasRelatedWork W2031452273 @default.
- W2404291019 hasRelatedWork W2036910956 @default.
- W2404291019 hasRelatedWork W2051607559 @default.
- W2404291019 hasRelatedWork W2054984160 @default.
- W2404291019 hasRelatedWork W2081954703 @default.
- W2404291019 hasRelatedWork W2089087180 @default.
- W2404291019 hasRelatedWork W2139130381 @default.
- W2404291019 hasRelatedWork W2162265568 @default.
- W2404291019 hasRelatedWork W2415945220 @default.
- W2404291019 hasRelatedWork W2978826924 @default.
- W2404291019 hasVolume "19" @default.
- W2404291019 isParatext "false" @default.
- W2404291019 isRetracted "false" @default.
- W2404291019 magId "2404291019" @default.
- W2404291019 workType "article" @default.