FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2404379596> ?p ?o ?g. }

• W2404379596 endingPage "356" @default.
• W2404379596 startingPage "352" @default.
• W2404379596 abstract "Abstract The regulatory role of leukotrienes (LT) on human myelopoiesis was investigated. Mononuclear bone marrow cells from 31 healthy donors were cultivated in the presence of suboptimal concentrations of recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) for 10 days in semisolid agar. The addition of LTC4 or LTB4 to the cultures dose- dependently stimulated myeloid stem cell proliferation. Maximal effects were observed at 10(-8) mol/L, at which LTC4 induced a 91% +/- 23% (mean +/- SEM; P = .004) and LTB4 a 73% +/- 22% (P = .008) increase in colony formation. In contrast, addition of the LTB4 isomer 5(S), 12(S)- diHETE did not affect the growth. LTD4 exerted a weak potentiating effect on progenitor proliferation (17% +/- 7% growth stimulation at 10(-10) mol/L; P = .034), whereas LTE4 was without consistent effect. Furthermore, LTC4-induced stimulation of colony formation was insensitive to the LTD4 antagonist ICI 198615. The dual lipoxygenase and prostaglandin endoperoxide synthase inhibitor CL42A potently suppressed the proliferation of myeloid colonies, a suppression that could be reversed by parallel addition of LTB4 or LTC4. The results suggest that both LTB4 and LTC4 possess strong and specific synergistic stimulatory effects on GM-CSF-induced human myeloid progenitor cell growth." @default.
• W2404379596 created "2016-06-24" @default.
• W2404379596 creator A5002063554 @default.
• W2404379596 creator A5009460759 @default.
• W2404379596 creator A5066820395 @default.
• W2404379596 creator A5074740795 @default.
• W2404379596 date "1993-01-15" @default.
• W2404379596 modified "2023-10-18" @default.
• W2404379596 title "Stimulation of human myelopoiesis by leukotrienes B4 and C4: interactions with granulocyte-macrophage colony-stimulating factor" @default.
• W2404379596 cites W1561256649 @default.
• W2404379596 cites W1584053655 @default.
• W2404379596 cites W1978972285 @default.
• W2404379596 cites W1991421537 @default.
• W2404379596 cites W1992458754 @default.
• W2404379596 cites W2011584193 @default.
• W2404379596 cites W2012253223 @default.
• W2404379596 cites W2016011359 @default.
• W2404379596 cites W2024176341 @default.
• W2404379596 cites W2024350919 @default.
• W2404379596 cites W2029791404 @default.
• W2404379596 cites W2036631709 @default.
• W2404379596 cites W2040931991 @default.
• W2404379596 cites W2052322037 @default.
• W2404379596 cites W2055384723 @default.
• W2404379596 cites W2120179212 @default.
• W2404379596 cites W2161459826 @default.
• W2404379596 cites W2181628422 @default.
• W2404379596 cites W2229653903 @default.
• W2404379596 cites W2395428351 @default.
• W2404379596 cites W2416368473 @default.
• W2404379596 cites W2443199170 @default.
• W2404379596 cites W2465718698 @default.
• W2404379596 cites W2505179795 @default.
• W2404379596 cites W70030604 @default.
• W2404379596 doi "https://doi.org/10.1182/blood.v81.2.352.352" @default.
• W2404379596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8380723" @default.
• W2404379596 hasPublicationYear "1993" @default.
• W2404379596 type Work @default.
• W2404379596 sameAs 2404379596 @default.
• W2404379596 citedByCount "62" @default.
• W2404379596 countsByYear W24043795962012 @default.
• W2404379596 countsByYear W24043795962015 @default.
• W2404379596 countsByYear W24043795962016 @default.
• W2404379596 countsByYear W24043795962020 @default.
• W2404379596 countsByYear W24043795962021 @default.
• W2404379596 countsByYear W24043795962022 @default.
• W2404379596 crossrefType "journal-article" @default.
• W2404379596 hasAuthorship W2404379596A5002063554 @default.
• W2404379596 hasAuthorship W2404379596A5009460759 @default.
• W2404379596 hasAuthorship W2404379596A5066820395 @default.
• W2404379596 hasAuthorship W2404379596A5074740795 @default.
• W2404379596 hasBestOaLocation W24043795961 @default.
• W2404379596 hasConcept C109159458 @default.
• W2404379596 hasConcept C126322002 @default.
• W2404379596 hasConcept C134018914 @default.
• W2404379596 hasConcept C170493617 @default.
• W2404379596 hasConcept C201750760 @default.
• W2404379596 hasConcept C203014093 @default.
• W2404379596 hasConcept C24998067 @default.
• W2404379596 hasConcept C2775960820 @default.
• W2404379596 hasConcept C2776042228 @default.
• W2404379596 hasConcept C2776452501 @default.
• W2404379596 hasConcept C2776685179 @default.
• W2404379596 hasConcept C2776914184 @default.
• W2404379596 hasConcept C2777983669 @default.
• W2404379596 hasConcept C2779282312 @default.
• W2404379596 hasConcept C28328180 @default.
• W2404379596 hasConcept C55493867 @default.
• W2404379596 hasConcept C71924100 @default.
• W2404379596 hasConcept C86803240 @default.
• W2404379596 hasConcept C880424 @default.
• W2404379596 hasConcept C95444343 @default.
• W2404379596 hasConcept C95862172 @default.
• W2404379596 hasConceptScore W2404379596C109159458 @default.
• W2404379596 hasConceptScore W2404379596C126322002 @default.
• W2404379596 hasConceptScore W2404379596C134018914 @default.
• W2404379596 hasConceptScore W2404379596C170493617 @default.
• W2404379596 hasConceptScore W2404379596C201750760 @default.
• W2404379596 hasConceptScore W2404379596C203014093 @default.
• W2404379596 hasConceptScore W2404379596C24998067 @default.
• W2404379596 hasConceptScore W2404379596C2775960820 @default.
• W2404379596 hasConceptScore W2404379596C2776042228 @default.
• W2404379596 hasConceptScore W2404379596C2776452501 @default.
• W2404379596 hasConceptScore W2404379596C2776685179 @default.
• W2404379596 hasConceptScore W2404379596C2776914184 @default.
• W2404379596 hasConceptScore W2404379596C2777983669 @default.
• W2404379596 hasConceptScore W2404379596C2779282312 @default.
• W2404379596 hasConceptScore W2404379596C28328180 @default.
• W2404379596 hasConceptScore W2404379596C55493867 @default.
• W2404379596 hasConceptScore W2404379596C71924100 @default.
• W2404379596 hasConceptScore W2404379596C86803240 @default.
• W2404379596 hasConceptScore W2404379596C880424 @default.
• W2404379596 hasConceptScore W2404379596C95444343 @default.
• W2404379596 hasConceptScore W2404379596C95862172 @default.
• W2404379596 hasIssue "2" @default.
• W2404379596 hasLocation W24043795961 @default.
• W2404379596 hasOpenAccess W2404379596 @default.
• W2404379596 hasPrimaryLocation W24043795961 @default.

• next