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• W2404434366 abstract "// Ryan L. Hanson 1 , Roger B. Brown 2 , Maria M. Steele 1 , Paul M. Grandgenett 1 , James A. Grunkemeyer 1 , Michael A. Hollingsworth 1 1 Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA 2 University of New Mexico, Albuquerque, NM 87131, USA Correspondence to: Michael A. Hollingsworth, email: mahollin@unmc.edu Keywords: FRA-1, MUC1, ERK, pancreatic cancer, invasion Received: April 04, 2016      Accepted: May 10, 2016      Published: May 23, 2016 ABSTRACT The MUC1 glycoprotein is overexpressed and aberrantly glycosylated in >90% of pancreatic ductal adenocarcinoma cases and impacts tumor progression by initiating downstream signaling through phosphorylation of its cytoplasmic tail. Previous studies have demonstrated that MUC1 alters expression of known targets of activator protein 1 (AP-1); however, no studies have evaluated the precise impact of MUC1 signaling on the activity and formation of AP-1. Given the known role of these proteins in modulating migration, invasion, and tumor progression, we explored the effects of MUC1 on AP-1 dimer formation and function. We determined that MUC1 increased the protein levels of c-Jun, the major component of AP-1, and promoted dimerization of c-Jun with the Fos-protein FRA-1. We demonstrate that FRA-1 acts as a potent mediator of migration and invasion in a manner that is modulated by signals through MUC1, which acts as a dominant regulator of specific AP-1 and FRA-1 target genes. Our results provide the first in vivo evidence of a FRA-1 mediated expression profile that impacts pancreatic tumor growth properties. In summary, we show that MUC1 enhancement of ERK activation influences FRA-1 activity to modulate tumor migration, invasion and metastasis in a subset of pancreatic cancer cases." @default.
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• W2404434366 date "2016-05-23" @default.
• W2404434366 modified "2023-10-02" @default.
• W2404434366 title "Identification of FRA-1 as a novel player in pancreatic cancer in cooperation with a MUC1: ERK signaling axis" @default.
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• W2404434366 doi "https://doi.org/10.18632/oncotarget.9557" @default.
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