Matches in SemOpenAlex for { <https://semopenalex.org/work/W2404444983> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2404444983 endingPage "7" @default.
- W2404444983 startingPage "2073" @default.
- W2404444983 abstract "Malignant gliomas are relatively resistant to radiation and chemotherapy. To investigate whether cisplatin (cis-diamminedichloroplatinum(II), CDDP) causes resistance we pretreated C6 cells with 10(-6) M CDDP for 24 hours and then tested their sensitivity in a colorimetric assay. Pretreated cells developed resistance to CDDP (resistance factor 2.0) and radiation (survival after 9 Gy 60Co: 36.4% +/- 5.5 versus 28.6% +/- 5.2, p = 0.005). Glutathione levels of pretreated cells were higher (51.7 +/- 13.8 ng/mg protein) than in wt cells (40.4 +/- 13.2, p = 0.029). Addressing the mechanisms we established 4 wild type subclones with different CDDP sensitivities. However, cross-resistance to CDDP (survival: 60.7% +/- 3.5 versus 7.2% +/- 0.5, respectively p = < 0.001) and radiation (29.7% +/- 2.6 versus 12.9% +/- 0.8, p = < 0.001) could also be induced in a subclone showing involvement of mutation. These data suggest that CDDP can induce resistance mediated via induced mutation and increased GSH levels." @default.
- W2404444983 created "2016-06-24" @default.
- W2404444983 creator A5025165118 @default.
- W2404444983 creator A5041011083 @default.
- W2404444983 creator A5060931240 @default.
- W2404444983 creator A5062013948 @default.
- W2404444983 creator A5074694794 @default.
- W2404444983 date "1997-05-01" @default.
- W2404444983 modified "2023-09-23" @default.
- W2404444983 title "C6 cells cross-resistant to cisplatin and radiation." @default.
- W2404444983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9216666" @default.
- W2404444983 hasPublicationYear "1997" @default.
- W2404444983 type Work @default.
- W2404444983 sameAs 2404444983 @default.
- W2404444983 citedByCount "5" @default.
- W2404444983 crossrefType "journal-article" @default.
- W2404444983 hasAuthorship W2404444983A5025165118 @default.
- W2404444983 hasAuthorship W2404444983A5041011083 @default.
- W2404444983 hasAuthorship W2404444983A5060931240 @default.
- W2404444983 hasAuthorship W2404444983A5062013948 @default.
- W2404444983 hasAuthorship W2404444983A5074694794 @default.
- W2404444983 hasConcept C104317684 @default.
- W2404444983 hasConcept C111337013 @default.
- W2404444983 hasConcept C121332964 @default.
- W2404444983 hasConcept C126322002 @default.
- W2404444983 hasConcept C153911025 @default.
- W2404444983 hasConcept C181199279 @default.
- W2404444983 hasConcept C185544564 @default.
- W2404444983 hasConcept C185592680 @default.
- W2404444983 hasConcept C26114605 @default.
- W2404444983 hasConcept C2776694085 @default.
- W2404444983 hasConcept C2778080818 @default.
- W2404444983 hasConcept C2778239845 @default.
- W2404444983 hasConcept C501734568 @default.
- W2404444983 hasConcept C502942594 @default.
- W2404444983 hasConcept C538909803 @default.
- W2404444983 hasConcept C54355233 @default.
- W2404444983 hasConcept C55493867 @default.
- W2404444983 hasConcept C71924100 @default.
- W2404444983 hasConcept C86803240 @default.
- W2404444983 hasConceptScore W2404444983C104317684 @default.
- W2404444983 hasConceptScore W2404444983C111337013 @default.
- W2404444983 hasConceptScore W2404444983C121332964 @default.
- W2404444983 hasConceptScore W2404444983C126322002 @default.
- W2404444983 hasConceptScore W2404444983C153911025 @default.
- W2404444983 hasConceptScore W2404444983C181199279 @default.
- W2404444983 hasConceptScore W2404444983C185544564 @default.
- W2404444983 hasConceptScore W2404444983C185592680 @default.
- W2404444983 hasConceptScore W2404444983C26114605 @default.
- W2404444983 hasConceptScore W2404444983C2776694085 @default.
- W2404444983 hasConceptScore W2404444983C2778080818 @default.
- W2404444983 hasConceptScore W2404444983C2778239845 @default.
- W2404444983 hasConceptScore W2404444983C501734568 @default.
- W2404444983 hasConceptScore W2404444983C502942594 @default.
- W2404444983 hasConceptScore W2404444983C538909803 @default.
- W2404444983 hasConceptScore W2404444983C54355233 @default.
- W2404444983 hasConceptScore W2404444983C55493867 @default.
- W2404444983 hasConceptScore W2404444983C71924100 @default.
- W2404444983 hasConceptScore W2404444983C86803240 @default.
- W2404444983 hasIssue "3C" @default.
- W2404444983 hasLocation W24044449831 @default.
- W2404444983 hasOpenAccess W2404444983 @default.
- W2404444983 hasPrimaryLocation W24044449831 @default.
- W2404444983 hasRelatedWork W1431768425 @default.
- W2404444983 hasRelatedWork W2042403432 @default.
- W2404444983 hasRelatedWork W2044918757 @default.
- W2404444983 hasRelatedWork W2049263374 @default.
- W2404444983 hasRelatedWork W2054383146 @default.
- W2404444983 hasRelatedWork W2067117419 @default.
- W2404444983 hasRelatedWork W2404444983 @default.
- W2404444983 hasRelatedWork W2411145041 @default.
- W2404444983 hasRelatedWork W2972697340 @default.
- W2404444983 hasRelatedWork W43627072 @default.
- W2404444983 hasVolume "17" @default.
- W2404444983 isParatext "false" @default.
- W2404444983 isRetracted "false" @default.
- W2404444983 magId "2404444983" @default.
- W2404444983 workType "article" @default.