FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2404455434> ?p ?o ?g. }

• W2404455434 endingPage "1224" @default.
• W2404455434 startingPage "1211" @default.
• W2404455434 abstract "To allow for sufficient time to repair DNA double-stranded breaks (DSBs), eukaryotic cells activate the DNA damage checkpoint. In budding yeast, Rad53 (mammalian Chk2) phosphorylation parallels the persistence of the unrepaired DSB and is extinguished when repair is complete in a process termed recovery or when the cells adapt to the DNA damage checkpoint. A strain containing a slowly repaired DSB does not require the histone chaperone Asf1 to resume cell cycle progression after DSB repair. When a second, rapidly repairable DSB is added to this strain, Asf1 becomes required for recovery. Recovery from two repairable DSBs also depends on the histone acetyltransferase Rtt109 and the cullin subunit Rtt101, both of which modify histone H3 that is associated with Asf1. We show that dissociation of histone H3 from Asf1 is required for efficient recovery and that Asf1 is required for complete dephosphorylation of Rad53 when the upstream DNA damage checkpoint signaling is turned off. Our data suggest that the requirements for recovery from the DNA damage checkpoint become more stringent with increased levels of damage and that Asf1 plays a histone chaperone-independent role in facilitating complete Rad53 dephosphorylation following repair." @default.
• W2404455434 created "2016-06-24" @default.
• W2404455434 creator A5001037106 @default.
• W2404455434 creator A5007474774 @default.
• W2404455434 creator A5020046284 @default.
• W2404455434 creator A5048113506 @default.
• W2404455434 creator A5050683716 @default.
• W2404455434 creator A5053069378 @default.
• W2404455434 creator A5085085286 @default.
• W2404455434 date "2016-05-15" @default.
• W2404455434 modified "2023-10-17" @default.
• W2404455434 title "Asf1 facilitates dephosphorylation of Rad53 after DNA double-strand break repair" @default.
• W2404455434 cites W1512281455 @default.
• W2404455434 cites W1560496206 @default.
• W2404455434 cites W1808208779 @default.
• W2404455434 cites W1961560739 @default.
• W2404455434 cites W1965341449 @default.
• W2404455434 cites W1967439841 @default.
• W2404455434 cites W1967834407 @default.
• W2404455434 cites W1968552183 @default.
• W2404455434 cites W1978054036 @default.
• W2404455434 cites W1980725176 @default.
• W2404455434 cites W1981934737 @default.
• W2404455434 cites W1983623780 @default.
• W2404455434 cites W1987721350 @default.
• W2404455434 cites W1989136612 @default.
• W2404455434 cites W1990103859 @default.
• W2404455434 cites W2010578066 @default.
• W2404455434 cites W2011287943 @default.
• W2404455434 cites W2024442567 @default.
• W2404455434 cites W2027928541 @default.
• W2404455434 cites W2031292590 @default.
• W2404455434 cites W2035910115 @default.
• W2404455434 cites W2041065032 @default.
• W2404455434 cites W2043895957 @default.
• W2404455434 cites W2045090937 @default.
• W2404455434 cites W2045959185 @default.
• W2404455434 cites W2048729396 @default.
• W2404455434 cites W2048908822 @default.
• W2404455434 cites W2049353065 @default.
• W2404455434 cites W2051289873 @default.
• W2404455434 cites W2051302495 @default.
• W2404455434 cites W2053289821 @default.
• W2404455434 cites W2055604308 @default.
• W2404455434 cites W2056029006 @default.
• W2404455434 cites W2058223290 @default.
• W2404455434 cites W2062185406 @default.
• W2404455434 cites W2062309902 @default.
• W2404455434 cites W2063607742 @default.
• W2404455434 cites W2065431856 @default.
• W2404455434 cites W2069334332 @default.
• W2404455434 cites W2077436902 @default.
• W2404455434 cites W2079156670 @default.
• W2404455434 cites W2083753924 @default.
• W2404455434 cites W2086516583 @default.
• W2404455434 cites W2086932102 @default.
• W2404455434 cites W2088853419 @default.
• W2404455434 cites W2089731808 @default.
• W2404455434 cites W2091204939 @default.
• W2404455434 cites W2102433010 @default.
• W2404455434 cites W2103427783 @default.
• W2404455434 cites W2105989207 @default.
• W2404455434 cites W2107130407 @default.
• W2404455434 cites W2108436181 @default.
• W2404455434 cites W2111159182 @default.
• W2404455434 cites W2113603158 @default.
• W2404455434 cites W2119386919 @default.
• W2404455434 cites W2121664774 @default.
• W2404455434 cites W2125666185 @default.
• W2404455434 cites W2126492332 @default.
• W2404455434 cites W2129068490 @default.
• W2404455434 cites W2129230649 @default.
• W2404455434 cites W2136849444 @default.
• W2404455434 cites W2138539875 @default.
• W2404455434 cites W2140454994 @default.
• W2404455434 cites W2145506563 @default.
• W2404455434 cites W2145929363 @default.
• W2404455434 cites W2147339231 @default.
• W2404455434 cites W2148530409 @default.
• W2404455434 cites W2150688223 @default.
• W2404455434 cites W2165337946 @default.
• W2404455434 cites W2166951778 @default.
• W2404455434 cites W2167365794 @default.
• W2404455434 cites W2168825528 @default.
• W2404455434 cites W2169911836 @default.
• W2404455434 cites W4242509748 @default.
• W2404455434 doi "https://doi.org/10.1101/gad.280685.116" @default.
• W2404455434 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4888841" @default.
• W2404455434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27222517" @default.
• W2404455434 hasPublicationYear "2016" @default.
• W2404455434 type Work @default.
• W2404455434 sameAs 2404455434 @default.
• W2404455434 citedByCount "19" @default.
• W2404455434 countsByYear W24044554342016 @default.
• W2404455434 countsByYear W24044554342017 @default.
• W2404455434 countsByYear W24044554342018 @default.
• W2404455434 countsByYear W24044554342019 @default.
• W2404455434 countsByYear W24044554342020 @default.

• next