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- W2404545296 endingPage "894" @default.
- W2404545296 startingPage "887" @default.
- W2404545296 abstract "Nitrite/nitrate salts are used in fertilizers and as food preservatives. Human exposure to high levels of nitrite results in its uptake and subsequent entry into blood where it can interact with erythrocytes. We show that treatment of human erythrocytes with sodium nitrite (NaNO2 ) results in a dose-dependent increase in the production of reactive oxygen species. This was accompanied by a decrease in the antioxidant power which lowered the free radical quenching and metal-reducing ability. NaNO2 treatment also inhibited plasma membrane redox system (PMRS) of erythrocytes. These changes increase the susceptibility of erythrocytes to oxidative damage, decrease the antioxidant power of whole blood, and can be a major cause of nitrite-induced cellular toxicity." @default.
- W2404545296 created "2016-06-24" @default.
- W2404545296 creator A5005163376 @default.
- W2404545296 creator A5023338166 @default.
- W2404545296 date "2016-06-06" @default.
- W2404545296 modified "2023-10-10" @default.
- W2404545296 title "Sodium nitrite enhances generation of reactive oxygen species that decrease antioxidant power and inhibit plasma membrane redox system of human erythrocytes" @default.
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- W2404545296 doi "https://doi.org/10.1002/cbin.10628" @default.
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