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- W2404628047 abstract "ABSTRACT In connexion with the experiments of Jurand (1958) on the action of TEM on avian embryos, it seems worthwhile describing very shortly some observations on the effects of this substance, and also of Myleran, on early amphibian embryos. Bodenstein (1954 and earlier) has described some of the cytological results of the administration of various ‘radio-mimetic’ substances to amphibian embryos, including nitrogen mustards and TEM. The effects on the development of the eye were particularly considered, and they have also been discussed and illustrated by Töndury (1955). Two main types of damage were noted, the formation of giant cells, and of cellular degeneration accompanied by nuclear breakdown and the formation of deeply staining cytoplasmic lumps. The giant cells presumably arise from the suppression of cell-division followed by the formation of a restitution nucleus. These nuclei stain rather palely, and appear to be lacking in DNA. On the other hand, the cytoplasmic globules which are commonly met with appear to consist of RNA, and to indicate an over-production of that compound." @default.
- W2404628047 created "2016-06-24" @default.
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- W2404628047 date "1958-06-01" @default.
- W2404628047 modified "2023-09-25" @default.
- W2404628047 title "A Note on the Effects of some Cytotoxic Substances on Amphibian Embryos" @default.
- W2404628047 cites W2071392313 @default.
- W2404628047 doi "https://doi.org/10.1242/dev.6.2.363" @default.
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