FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2404697974> ?p ?o ?g. }

• W2404697974 endingPage "442" @default.
• W2404697974 startingPage "436" @default.
• W2404697974 abstract "A randomized, double-blind study was designed to evaluate the therapeutic effect and safety of prostacyclin (epoprostenol) in patients undergoing cardiopulmonary bypass. One hundred patients having isolated coronary bypass grafting received 300 units/kg of heparin and then either prostacyclin (12.5 ng/kg/min from heparinization until cardiopulmonary bypass, 25 ng/kg/min during bypass) or buffer/diluent in a similar manner. Standardized anesthetic, perfusion, and surgical techniques were used. Drug and placebo groups were similar in demographic data and bypass times, and there were no deaths. Activated coagulation time and platelet count were significantly higher during cardiopulmonary bypass in patients receiving prostacyclin. Platelet count remained significantly higher 24 hours after bypass in the active drug group. Immediately after operation, there was significantly less prolongation of bleeding time (1.3 versus 2.9 minutes; p = 0.009) in the patients receiving prostacyclin. Blood loss was significantly reduced during the first 4 hours postoperatively in the prostacyclin group (261 +/- 159 versus 347 +/- 197 ml; p = 0.02). There was no significant difference between the groups when total blood loss was compared (710 +/- 351 versus 869 +/- 498 ml; p = 0.07). Patients receiving prostacyclin required an average of 257 ml less blood transfused in the intensive care unit (p = 0.02). We conclude that the clinical impact of prostacyclin in patients undergoing coronary artery operations was demonstrable, but small. Prostacyclin may provide clinical benefits in patients undergoing cardiopulmonary bypass when there are contraindications to or other difficulties with blood transfusion. With prostacyclin, reduced heparin dose is possible and therefore reduced protamine requirement would offer a potential benefit of less cardiovascular depression immediately after bypass. However, the advantages offered by prostacyclin are not sufficient to recommend its routine use during cardiopulmonary bypass." @default.
• W2404697974 created "2016-06-24" @default.
• W2404697974 creator A5002073300 @default.
• W2404697974 creator A5014042507 @default.
• W2404697974 creator A5014235995 @default.
• W2404697974 creator A5026867259 @default.
• W2404697974 creator A5028109655 @default.
• W2404697974 creator A5073284115 @default.
• W2404697974 creator A5077126991 @default.
• W2404697974 creator A5086486615 @default.
• W2404697974 date "1986-03-01" @default.
• W2404697974 modified "2023-10-16" @default.
• W2404697974 title "A prospective, randomized study of the effects of prostacyclin on platelets and blood loss during coronary bypass operations" @default.
• W2404697974 cites W1969575905 @default.
• W2404697974 cites W1978240846 @default.
• W2404697974 cites W1996999357 @default.
• W2404697974 cites W1999386605 @default.
• W2404697974 cites W2021272127 @default.
• W2404697974 cites W2031694896 @default.
• W2404697974 cites W2045461798 @default.
• W2404697974 cites W2056454083 @default.
• W2404697974 cites W2062185761 @default.
• W2404697974 cites W2085793029 @default.
• W2404697974 cites W2397660008 @default.
• W2404697974 cites W2399495832 @default.
• W2404697974 cites W2403972555 @default.
• W2404697974 cites W2412731382 @default.
• W2404697974 cites W2473585115 @default.
• W2404697974 cites W2474946206 @default.
• W2404697974 cites W4293363093 @default.
• W2404697974 doi "https://doi.org/10.1016/s0022-5223(19)36060-x" @default.
• W2404697974 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3512919" @default.
• W2404697974 hasPublicationYear "1986" @default.
• W2404697974 type Work @default.
• W2404697974 sameAs 2404697974 @default.
• W2404697974 citedByCount "80" @default.
• W2404697974 countsByYear W24046979742013 @default.
• W2404697974 countsByYear W24046979742014 @default.
• W2404697974 countsByYear W24046979742017 @default.
• W2404697974 countsByYear W24046979742020 @default.
• W2404697974 crossrefType "journal-article" @default.
• W2404697974 hasAuthorship W2404697974A5002073300 @default.
• W2404697974 hasAuthorship W2404697974A5014042507 @default.
• W2404697974 hasAuthorship W2404697974A5014235995 @default.
• W2404697974 hasAuthorship W2404697974A5026867259 @default.
• W2404697974 hasAuthorship W2404697974A5028109655 @default.
• W2404697974 hasAuthorship W2404697974A5073284115 @default.
• W2404697974 hasAuthorship W2404697974A5077126991 @default.
• W2404697974 hasAuthorship W2404697974A5086486615 @default.
• W2404697974 hasBestOaLocation W24046979741 @default.
• W2404697974 hasConcept C126322002 @default.
• W2404697974 hasConcept C141071460 @default.
• W2404697974 hasConcept C142724271 @default.
• W2404697974 hasConcept C164705383 @default.
• W2404697974 hasConcept C204787440 @default.
• W2404697974 hasConcept C27081682 @default.
• W2404697974 hasConcept C2776820930 @default.
• W2404697974 hasConcept C2777557582 @default.
• W2404697974 hasConcept C2778881276 @default.
• W2404697974 hasConcept C2781128415 @default.
• W2404697974 hasConcept C42219234 @default.
• W2404697974 hasConcept C71924100 @default.
• W2404697974 hasConcept C89560881 @default.
• W2404697974 hasConceptScore W2404697974C126322002 @default.
• W2404697974 hasConceptScore W2404697974C141071460 @default.
• W2404697974 hasConceptScore W2404697974C142724271 @default.
• W2404697974 hasConceptScore W2404697974C164705383 @default.
• W2404697974 hasConceptScore W2404697974C204787440 @default.
• W2404697974 hasConceptScore W2404697974C27081682 @default.
• W2404697974 hasConceptScore W2404697974C2776820930 @default.
• W2404697974 hasConceptScore W2404697974C2777557582 @default.
• W2404697974 hasConceptScore W2404697974C2778881276 @default.
• W2404697974 hasConceptScore W2404697974C2781128415 @default.
• W2404697974 hasConceptScore W2404697974C42219234 @default.
• W2404697974 hasConceptScore W2404697974C71924100 @default.
• W2404697974 hasConceptScore W2404697974C89560881 @default.
• W2404697974 hasIssue "3" @default.
• W2404697974 hasLocation W24046979741 @default.
• W2404697974 hasLocation W24046979742 @default.
• W2404697974 hasOpenAccess W2404697974 @default.
• W2404697974 hasPrimaryLocation W24046979741 @default.
• W2404697974 hasRelatedWork W1995047479 @default.
• W2404697974 hasRelatedWork W1996999357 @default.
• W2404697974 hasRelatedWork W2036623213 @default.
• W2404697974 hasRelatedWork W2062073913 @default.
• W2404697974 hasRelatedWork W2094866602 @default.
• W2404697974 hasRelatedWork W2418281388 @default.
• W2404697974 hasRelatedWork W2469315777 @default.
• W2404697974 hasRelatedWork W2471417634 @default.
• W2404697974 hasRelatedWork W32076284 @default.
• W2404697974 hasRelatedWork W4386383678 @default.
• W2404697974 hasVolume "91" @default.
• W2404697974 isParatext "false" @default.
• W2404697974 isRetracted "false" @default.
• W2404697974 magId "2404697974" @default.
• W2404697974 workType "article" @default.