Matches in SemOpenAlex for { <https://semopenalex.org/work/W2404726753> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2404726753 abstract "p53 alterations have been identified in approximately 23% of breast carcinomas, particularly in hormone receptor-negative high-grade carcinomas. It is considered to be an early event in breast carcinogenesis. Nevertheless, the putative precursor lesion of high-grade breast carcinoma remains elusive. Breast excision specimens from 93 triple-negative high-grade invasive ductal carcinomas, 48 estrogen receptor (ER)-positive/progesterone receptor-positive/Her2-negative non-high-grade invasive ductal carcinomas, and 50 mammoplasty breasts were selected. At least 2 tissue blocks with tumor and adjacent benign tissue were sectioned and subjected to immunohistochemistry staining for p53. TP53 gene sequencing was performed on select tumors. Further immunohistochemistry staining for ER and Ki-67 was performed on consecutive sections of tissue with p53-positive normal/benign cells. Of the 93 high-grade carcinomas, 51 (55%) were positive for p53 alteration, whereas only 3 (6.25%) of the 48 non-high-grade carcinomas were p53 altered. Focal p53 positivity in adjacent normal/benign breast tissue was identified in 19 cases, and 18 of them also had p53 alteration in their carcinomas. Only 1 case had focal p53 staining in normal/benign tissue, but the tumor was negative for p53 alteration. No p53 staining positivity was identified in the mammoplasty specimens. The p53-stained normal/benign cells were ER negative and did not show an increase in the Ki-67 labeling index. These findings indicate that the p53 staining positivity in normal/benign breast tissue is not a random event. It could be considered as the p53 signature in breast and serve as an indicator for future potential risk of p53-positive high-grade breast carcinoma." @default.
- W2404726753 created "2016-06-24" @default.
- W2404726753 creator A5010105551 @default.
- W2404726753 creator A5028987280 @default.
- W2404726753 creator A5038519989 @default.
- W2404726753 creator A5057866558 @default.
- W2404726753 creator A5075171048 @default.
- W2404726753 creator A5085211151 @default.
- W2404726753 creator A5087899523 @default.
- W2404726753 creator A5090428050 @default.
- W2404726753 date "2016-09-01" @default.
- W2404726753 modified "2023-10-17" @default.
- W2404726753 title "p53 alteration in morphologically normal/benign breast tissue in patients with triple-negative high-grade breast carcinomas: breast p53 signature?" @default.
- W2404726753 cites W1558526836 @default.
- W2404726753 cites W1958068799 @default.
- W2404726753 cites W1972680809 @default.
- W2404726753 cites W1978553767 @default.
- W2404726753 cites W2015204696 @default.
- W2404726753 cites W2032098468 @default.
- W2404726753 cites W2033737920 @default.
- W2404726753 cites W2049560881 @default.
- W2404726753 cites W2050276844 @default.
- W2404726753 cites W2052762729 @default.
- W2404726753 cites W2054785621 @default.
- W2404726753 cites W2096283457 @default.
- W2404726753 cites W2120431466 @default.
- W2404726753 cites W2148227665 @default.
- W2404726753 cites W2154049188 @default.
- W2404726753 cites W2155192329 @default.
- W2404726753 cites W2157840751 @default.
- W2404726753 cites W2169402240 @default.
- W2404726753 doi "https://doi.org/10.1016/j.humpath.2016.05.011" @default.
- W2404726753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27246177" @default.
- W2404726753 hasPublicationYear "2016" @default.
- W2404726753 type Work @default.
- W2404726753 sameAs 2404726753 @default.
- W2404726753 citedByCount "3" @default.
- W2404726753 countsByYear W24047267532017 @default.
- W2404726753 countsByYear W24047267532020 @default.
- W2404726753 countsByYear W24047267532021 @default.
- W2404726753 crossrefType "journal-article" @default.
- W2404726753 hasAuthorship W2404726753A5010105551 @default.
- W2404726753 hasAuthorship W2404726753A5028987280 @default.
- W2404726753 hasAuthorship W2404726753A5038519989 @default.
- W2404726753 hasAuthorship W2404726753A5057866558 @default.
- W2404726753 hasAuthorship W2404726753A5075171048 @default.
- W2404726753 hasAuthorship W2404726753A5085211151 @default.
- W2404726753 hasAuthorship W2404726753A5087899523 @default.
- W2404726753 hasAuthorship W2404726753A5090428050 @default.
- W2404726753 hasConcept C121608353 @default.
- W2404726753 hasConcept C126322002 @default.
- W2404726753 hasConcept C142724271 @default.
- W2404726753 hasConcept C204232928 @default.
- W2404726753 hasConcept C2777546739 @default.
- W2404726753 hasConcept C2777751288 @default.
- W2404726753 hasConcept C2780862961 @default.
- W2404726753 hasConcept C3018521938 @default.
- W2404726753 hasConcept C530470458 @default.
- W2404726753 hasConcept C71924100 @default.
- W2404726753 hasConcept C74864618 @default.
- W2404726753 hasConcept C84606932 @default.
- W2404726753 hasConcept C86803240 @default.
- W2404726753 hasConcept C98717036 @default.
- W2404726753 hasConceptScore W2404726753C121608353 @default.
- W2404726753 hasConceptScore W2404726753C126322002 @default.
- W2404726753 hasConceptScore W2404726753C142724271 @default.
- W2404726753 hasConceptScore W2404726753C204232928 @default.
- W2404726753 hasConceptScore W2404726753C2777546739 @default.
- W2404726753 hasConceptScore W2404726753C2777751288 @default.
- W2404726753 hasConceptScore W2404726753C2780862961 @default.
- W2404726753 hasConceptScore W2404726753C3018521938 @default.
- W2404726753 hasConceptScore W2404726753C530470458 @default.
- W2404726753 hasConceptScore W2404726753C71924100 @default.
- W2404726753 hasConceptScore W2404726753C74864618 @default.
- W2404726753 hasConceptScore W2404726753C84606932 @default.
- W2404726753 hasConceptScore W2404726753C86803240 @default.
- W2404726753 hasConceptScore W2404726753C98717036 @default.
- W2404726753 hasLocation W24047267531 @default.
- W2404726753 hasLocation W24047267532 @default.
- W2404726753 hasOpenAccess W2404726753 @default.
- W2404726753 hasPrimaryLocation W24047267531 @default.
- W2404726753 hasRelatedWork W1970614368 @default.
- W2404726753 hasRelatedWork W1995899364 @default.
- W2404726753 hasRelatedWork W2110041566 @default.
- W2404726753 hasRelatedWork W2266353954 @default.
- W2404726753 hasRelatedWork W2271528792 @default.
- W2404726753 hasRelatedWork W2409481895 @default.
- W2404726753 hasRelatedWork W3030607533 @default.
- W2404726753 hasRelatedWork W3109088106 @default.
- W2404726753 hasRelatedWork W3200969472 @default.
- W2404726753 hasRelatedWork W2097535930 @default.
- W2404726753 isParatext "false" @default.
- W2404726753 isRetracted "false" @default.
- W2404726753 magId "2404726753" @default.
- W2404726753 workType "article" @default.