FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2404735349> ?p ?o ?g. }

• W2404735349 abstract "The protective effect of a mixed powder from solid-cultured and liquid-cultured Lentinus edodes mycelia (2:1, w/w) (designate LED) on the carbon tetrachloride (CCl₄)- and ethanol-induced hepatotoxicity of male Sprague-Dawley (SD) rat was investigated. In the CCl₄-induced rat hepatotoxicity experiment, rats of 4 groups (6 rats/group) were administere with Normal (0.2 ml distilled water), Control (0.2 ml distilled water), LED (LED 200 ㎎/㎏ BW + 0.2 ml distilled water), and Silymarin (200 ㎎/㎏ BW + 0.2 ml distilled water), p.o., daily for 2 weeks. Afterwards, all groups except for the Normal group were subjected to abdominal injection with CCl₄ (CCl₄: corn oil, 1:1 v/v; 0.5 ml/㎏ BW). For the ethanol- induced rat hepatotoxicity experiment, rats were divided into 5 groups (5 rats/group): Normal; Pair-fed control (PFC); Control (ethanol); LED (ethanol + LED 200 ㎎/㎏ BW); and Silymarin (ethanol + silymarin 200 ㎎/㎏ BW). Rats of the Normal and PFC groups were fed a basal liquid diet, and rats of the Control, LED, and Silymarin groups were fed a liquid ethanol diet containing LED or Silymarin. Eight weeks later, blood and liver samples were collected to analyze biomarkers. In CCl₄-induced SD rats, LED elevated hepatic superoxide dismutase (SOD), catalase, and glutathione peroxidase (GSH peroxidase) activities and thiobarbituric reactive substances (TBARS) were reduced, resulting in the reduction of glutamate-oxalate transaminase (GOT), glutamate-pyruvate transaminase (GPT) and lactic dehydrogenase (LDH) activities in plasma. Similar results of these enzymes and biochemical markers in both liver tissues and plasma were seen in ethanol-induced hepatotoxicity of SD rats. In addition, elevated alcohol dehydrogenase (ADH) activity and reduced expression of cytochrome p450 mixed monooxygenase enzyme (CYP2E1) were seen in liver tissues from ethanol-treated rats by LED treatment. These effects of LED were similar to those of Silymarin. In in vitro experiments, LED showed antioxidant activity in a 2,2-diphenyl-1-picrylhydrazyl (DPPH) system and mouse liver mitochondria system induced by NADPH/Fe 2+ and cumine hydroperoxide (CuOOH). These results indicate that LED protected SD rat hepatotoxicity, induced by CCl₄ and ethanol, through its antioxidative activity and might be useful as a material for protection from hepatoxicity in humans." @default.
• W2404735349 created "2016-06-24" @default.
• W2404735349 creator A5016601490 @default.
• W2404735349 creator A5022094869 @default.
• W2404735349 creator A5028955636 @default.
• W2404735349 creator A5046663469 @default.
• W2404735349 creator A5050495646 @default.
• W2404735349 creator A5082418557 @default.
• W2404735349 creator A5090746393 @default.
• W2404735349 date "2010-01-30" @default.
• W2404735349 modified "2023-09-24" @default.
• W2404735349 title "Mycelial Culture of Lentinus edodes Alleviates Rat Liver Toxicity Induced by Carbon Tetrachloride and Ethanol" @default.
• W2404735349 cites W1990633347 @default.
• W2404735349 cites W2153124385 @default.
• W2404735349 doi "https://doi.org/10.5352/jls.2010.20.1.133" @default.
• W2404735349 hasPublicationYear "2010" @default.
• W2404735349 type Work @default.
• W2404735349 sameAs 2404735349 @default.
• W2404735349 citedByCount "2" @default.
• W2404735349 countsByYear W24047353492015 @default.
• W2404735349 countsByYear W24047353492021 @default.
• W2404735349 crossrefType "journal-article" @default.
• W2404735349 hasAuthorship W2404735349A5016601490 @default.
• W2404735349 hasAuthorship W2404735349A5022094869 @default.
• W2404735349 hasAuthorship W2404735349A5028955636 @default.
• W2404735349 hasAuthorship W2404735349A5046663469 @default.
• W2404735349 hasAuthorship W2404735349A5050495646 @default.
• W2404735349 hasAuthorship W2404735349A5082418557 @default.
• W2404735349 hasAuthorship W2404735349A5090746393 @default.
• W2404735349 hasBestOaLocation W24047353491 @default.
• W2404735349 hasConcept C160160445 @default.
• W2404735349 hasConcept C178790620 @default.
• W2404735349 hasConcept C181199279 @default.
• W2404735349 hasConcept C185592680 @default.
• W2404735349 hasConcept C2775838275 @default.
• W2404735349 hasConcept C2776877979 @default.
• W2404735349 hasConcept C2777352226 @default.
• W2404735349 hasConcept C2777359374 @default.
• W2404735349 hasConcept C2777504301 @default.
• W2404735349 hasConcept C2778004101 @default.
• W2404735349 hasConcept C2778760513 @default.
• W2404735349 hasConcept C2778979269 @default.
• W2404735349 hasConcept C2779429693 @default.
• W2404735349 hasConcept C2779679107 @default.
• W2404735349 hasConcept C2780161600 @default.
• W2404735349 hasConcept C2780829032 @default.
• W2404735349 hasConcept C31903555 @default.
• W2404735349 hasConcept C43617362 @default.
• W2404735349 hasConcept C55493867 @default.
• W2404735349 hasConcept C71924100 @default.
• W2404735349 hasConcept C98274493 @default.
• W2404735349 hasConceptScore W2404735349C160160445 @default.
• W2404735349 hasConceptScore W2404735349C178790620 @default.
• W2404735349 hasConceptScore W2404735349C181199279 @default.
• W2404735349 hasConceptScore W2404735349C185592680 @default.
• W2404735349 hasConceptScore W2404735349C2775838275 @default.
• W2404735349 hasConceptScore W2404735349C2776877979 @default.
• W2404735349 hasConceptScore W2404735349C2777352226 @default.
• W2404735349 hasConceptScore W2404735349C2777359374 @default.
• W2404735349 hasConceptScore W2404735349C2777504301 @default.
• W2404735349 hasConceptScore W2404735349C2778004101 @default.
• W2404735349 hasConceptScore W2404735349C2778760513 @default.
• W2404735349 hasConceptScore W2404735349C2778979269 @default.
• W2404735349 hasConceptScore W2404735349C2779429693 @default.
• W2404735349 hasConceptScore W2404735349C2779679107 @default.
• W2404735349 hasConceptScore W2404735349C2780161600 @default.
• W2404735349 hasConceptScore W2404735349C2780829032 @default.
• W2404735349 hasConceptScore W2404735349C31903555 @default.
• W2404735349 hasConceptScore W2404735349C43617362 @default.
• W2404735349 hasConceptScore W2404735349C55493867 @default.
• W2404735349 hasConceptScore W2404735349C71924100 @default.
• W2404735349 hasConceptScore W2404735349C98274493 @default.
• W2404735349 hasLocation W24047353491 @default.
• W2404735349 hasOpenAccess W2404735349 @default.
• W2404735349 hasPrimaryLocation W24047353491 @default.
• W2404735349 hasRelatedWork W1486336081 @default.
• W2404735349 hasRelatedWork W185499269 @default.
• W2404735349 hasRelatedWork W1899250242 @default.
• W2404735349 hasRelatedWork W1981405187 @default.
• W2404735349 hasRelatedWork W1994576333 @default.
• W2404735349 hasRelatedWork W1999647919 @default.
• W2404735349 hasRelatedWork W2002830997 @default.
• W2404735349 hasRelatedWork W2030465082 @default.
• W2404735349 hasRelatedWork W2060854589 @default.
• W2404735349 hasRelatedWork W2083634601 @default.
• W2404735349 hasRelatedWork W2102510477 @default.
• W2404735349 hasRelatedWork W2186896172 @default.
• W2404735349 hasRelatedWork W2332832210 @default.
• W2404735349 hasRelatedWork W2555035115 @default.
• W2404735349 hasRelatedWork W2911324929 @default.
• W2404735349 hasRelatedWork W2943156558 @default.
• W2404735349 hasRelatedWork W3113616157 @default.
• W2404735349 hasRelatedWork W3115636279 @default.
• W2404735349 hasRelatedWork W3140945602 @default.
• W2404735349 hasRelatedWork W3171948640 @default.
• W2404735349 isParatext "false" @default.
• W2404735349 isRetracted "false" @default.
• W2404735349 magId "2404735349" @default.
• W2404735349 workType "article" @default.