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• W2404745333 endingPage "149" @default.
• W2404745333 startingPage "125" @default.
• W2404745333 abstract "Evidence accumulating over the past decade has linked alterations in bioenergetic metabolism to the pathogenesis of several diseases, including inflammatory conditions and cancer. However, the mutual relationship between the effector functions and the metabolism of immune cells has begun to emerge only recently. Similar to malignant cells, both innate and adaptive immune cells undergo a metabolic reprogramming that is required for effector functions, de facto underlying the elicitation of a robust immune response. These changes allow immune cells not only to rapidly respond to pathogens or (pre)malignant cells but also to adapt to changing microenvironmental conditions. Targeting the metabolic alterations of malignant cells has been the subject of an intense wave of investigation, resulting in the identification of promising therapeutic strategies. Since the inflammatory milieu and the tumor microenvironment are similar, the metabolism of immune cells and its regulation has recently come under renewed interest as a target for immunotherapy. Here, we describe different tools and techniques to study the bioenergetic metabolism of cultured cells, using immune cells as a model. Our methodological approach relies on an extracellular flux analyzer, an instrument that enables the real-time measurement of the two central pathways used by living cells to generate adenosine triphosphate: glycolysis and oxidative phosphorylation. This instrument and similar technological innovations have transformed the study of cellular metabolism, unveiling its profound impact on various immunologic and oncological disorders." @default.
• W2404745333 created "2016-06-24" @default.
• W2404745333 creator A5001689917 @default.
• W2404745333 creator A5022663310 @default.
• W2404745333 creator A5039929066 @default.
• W2404745333 creator A5043390034 @default.
• W2404745333 date "2014-01-01" @default.
• W2404745333 modified "2023-10-12" @default.
• W2404745333 title "Extracellular Flux Analysis to Monitor Glycolytic Rates and Mitochondrial Oxygen Consumption" @default.
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• W2404745333 doi "https://doi.org/10.1016/b978-0-12-416618-9.00007-8" @default.
• W2404745333 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24862264" @default.
• W2404745333 hasPublicationYear "2014" @default.
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