Matches in SemOpenAlex for { <https://semopenalex.org/work/W2404764145> ?p ?o ?g. }
- W2404764145 endingPage "643" @default.
- W2404764145 startingPage "636" @default.
- W2404764145 abstract "Intervertebral disc (IVD) degeneration is a common cause of low back pain. Testing potential therapeutics in the regeneration of the disc requires the use of model systems. Although several animal models have been developed to investigate IVD degeneration, they are technically challenging to prepare, expensive, present with limitations when performing biomechanical studies on the disc, and are impractical in large-scale screening of novel anabolic and scaffolding agents. An IVD organ culture system offers an inexpensive alternative. In the current paradigm, the bony endplates are removed to allow for nutrient diffusion and maintenance of disc cell viability. Although this is an excellent system for testing biologics, it results in concave cartilage endplates and, as such, requires special platens for loading purposes in a bioreactor as flat ones can overload the annular disc region leading to improper loading. Furthermore, the absence of bone makes it unsuitable for applying complex cyclic loading, a topic of interest in the study of chronic progressive degeneration, as multiaxial loading is more representative of daily forces encountered by the IVD. We have developed and validated a novel long-term IVD organ culture model that retains vertebral bone and is easy to prepare. Our model is ideal for testing potential drugs and alternate-based therapies, in addition to investigating the long-term effects of loading paradigms on disc degeneration and repair." @default.
- W2404764145 created "2016-06-24" @default.
- W2404764145 creator A5013713296 @default.
- W2404764145 creator A5014626013 @default.
- W2404764145 creator A5023449808 @default.
- W2404764145 creator A5028209585 @default.
- W2404764145 creator A5043034664 @default.
- W2404764145 creator A5043858525 @default.
- W2404764145 creator A5076549508 @default.
- W2404764145 creator A5078605559 @default.
- W2404764145 date "2016-07-01" @default.
- W2404764145 modified "2023-10-02" @default.
- W2404764145 title "Development of a Large Animal Long-Term Intervertebral Disc Organ Culture Model That Includes the Bony Vertebrae for <i>Ex Vivo</i> Studies" @default.
- W2404764145 cites W143623202 @default.
- W2404764145 cites W1581461985 @default.
- W2404764145 cites W1897804960 @default.
- W2404764145 cites W1965593333 @default.
- W2404764145 cites W1968316058 @default.
- W2404764145 cites W1968520537 @default.
- W2404764145 cites W1977581444 @default.
- W2404764145 cites W1984316576 @default.
- W2404764145 cites W1984594004 @default.
- W2404764145 cites W1986868734 @default.
- W2404764145 cites W1987228671 @default.
- W2404764145 cites W1992244280 @default.
- W2404764145 cites W1996701920 @default.
- W2404764145 cites W1996715533 @default.
- W2404764145 cites W1997828625 @default.
- W2404764145 cites W2006051929 @default.
- W2404764145 cites W2007470421 @default.
- W2404764145 cites W2009770780 @default.
- W2404764145 cites W2009840300 @default.
- W2404764145 cites W2011557285 @default.
- W2404764145 cites W2011936377 @default.
- W2404764145 cites W2021374356 @default.
- W2404764145 cites W2021412978 @default.
- W2404764145 cites W2021727935 @default.
- W2404764145 cites W2023584561 @default.
- W2404764145 cites W2024585159 @default.
- W2404764145 cites W2027990128 @default.
- W2404764145 cites W2030604088 @default.
- W2404764145 cites W2040939772 @default.
- W2404764145 cites W2075076411 @default.
- W2404764145 cites W2076136227 @default.
- W2404764145 cites W2087115556 @default.
- W2404764145 cites W2087563256 @default.
- W2404764145 cites W2088272358 @default.
- W2404764145 cites W2088633520 @default.
- W2404764145 cites W2089591376 @default.
- W2404764145 cites W2091025894 @default.
- W2404764145 cites W2091573615 @default.
- W2404764145 cites W2094458540 @default.
- W2404764145 cites W2101692026 @default.
- W2404764145 cites W2111763891 @default.
- W2404764145 cites W2129465868 @default.
- W2404764145 cites W2137373058 @default.
- W2404764145 cites W2142034162 @default.
- W2404764145 cites W2152983876 @default.
- W2404764145 cites W2162435517 @default.
- W2404764145 cites W2167942521 @default.
- W2404764145 cites W2320138524 @default.
- W2404764145 cites W2326211238 @default.
- W2404764145 cites W2410322647 @default.
- W2404764145 cites W32019318 @default.
- W2404764145 cites W4236569192 @default.
- W2404764145 cites W4293765706 @default.
- W2404764145 cites W4294855983 @default.
- W2404764145 cites W4361868163 @default.
- W2404764145 doi "https://doi.org/10.1089/ten.tec.2016.0049" @default.
- W2404764145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27216856" @default.
- W2404764145 hasPublicationYear "2016" @default.
- W2404764145 type Work @default.
- W2404764145 sameAs 2404764145 @default.
- W2404764145 citedByCount "18" @default.
- W2404764145 countsByYear W24047641452016 @default.
- W2404764145 countsByYear W24047641452018 @default.
- W2404764145 countsByYear W24047641452019 @default.
- W2404764145 countsByYear W24047641452020 @default.
- W2404764145 countsByYear W24047641452021 @default.
- W2404764145 countsByYear W24047641452022 @default.
- W2404764145 countsByYear W24047641452023 @default.
- W2404764145 crossrefType "journal-article" @default.
- W2404764145 hasAuthorship W2404764145A5013713296 @default.
- W2404764145 hasAuthorship W2404764145A5014626013 @default.
- W2404764145 hasAuthorship W2404764145A5023449808 @default.
- W2404764145 hasAuthorship W2404764145A5028209585 @default.
- W2404764145 hasAuthorship W2404764145A5043034664 @default.
- W2404764145 hasAuthorship W2404764145A5043858525 @default.
- W2404764145 hasAuthorship W2404764145A5076549508 @default.
- W2404764145 hasAuthorship W2404764145A5078605559 @default.
- W2404764145 hasConcept C105702510 @default.
- W2404764145 hasConcept C136229726 @default.
- W2404764145 hasConcept C141071460 @default.
- W2404764145 hasConcept C142724271 @default.
- W2404764145 hasConcept C150903083 @default.
- W2404764145 hasConcept C171056886 @default.
- W2404764145 hasConcept C207001950 @default.
- W2404764145 hasConcept C26291073 @default.