FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2404845416> ?p ?o ?g. }

• W2404845416 endingPage "42" @default.
• W2404845416 startingPage "633" @default.
• W2404845416 abstract "3-([4-(4-Chlorophenyl)piperazin-1-yl]-methyl)-1H-pyrrolo-2, 3-beta-pyridine (L-745,870) is a dopamine D(4) selective antagonist that has been studied as a potential treatment for schizophrenia, with the expectation that it would not exhibit the extrapyramidal side effects often observed with the use of classical antipsychotic agents. The metabolism of L-745,870 in vivo was investigated in the rat, rhesus monkey, and human using liquid chromatography-tandem mass spectrometry and/or NMR techniques in conjunction with radiochemical detection. In all three species, two major metabolic pathways were identified, namely N-dealkylation at the substituted piperazine moiety and the formation of a novel mercapturic acid adduct. It is proposed that the latter biotransformation process involves the formation of an electrophilic imine methide intermediate, analogous to that produced from 3-methyl indole. This report appears to represent the first example of metabolic activation of a 3-alkyl-7-azaindole nucleus." @default.
• W2404845416 created "2016-06-24" @default.
• W2404845416 creator A5003058999 @default.
• W2404845416 creator A5022210942 @default.
• W2404845416 creator A5046301560 @default.
• W2404845416 creator A5061465054 @default.
• W2404845416 creator A5064932633 @default.
• W2404845416 creator A5087980252 @default.
• W2404845416 date "2000-06-01" @default.
• W2404845416 modified "2023-09-23" @default.
• W2404845416 title "Metabolism of A dopamine D(4)-selective antagonist in rat, monkey, and humans: formation of A novel mercapturic acid adduct." @default.
• W2404845416 cites W1516084644 @default.
• W2404845416 cites W15831187 @default.
• W2404845416 cites W1923326352 @default.
• W2404845416 cites W1966900917 @default.
• W2404845416 cites W1974865048 @default.
• W2404845416 cites W1979258932 @default.
• W2404845416 cites W1992932912 @default.
• W2404845416 cites W1996735957 @default.
• W2404845416 cites W1998052476 @default.
• W2404845416 cites W2008170648 @default.
• W2404845416 cites W2023783869 @default.
• W2404845416 cites W2024189501 @default.
• W2404845416 cites W2026275409 @default.
• W2404845416 cites W2058044394 @default.
• W2404845416 cites W2070950079 @default.
• W2404845416 cites W2072121992 @default.
• W2404845416 cites W2075028631 @default.
• W2404845416 cites W2087688448 @default.
• W2404845416 cites W2097042950 @default.
• W2404845416 cites W2151331628 @default.
• W2404845416 cites W2184597224 @default.
• W2404845416 cites W2399518853 @default.
• W2404845416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10820134" @default.
• W2404845416 hasPublicationYear "2000" @default.
• W2404845416 type Work @default.
• W2404845416 sameAs 2404845416 @default.
• W2404845416 citedByCount "1" @default.
• W2404845416 crossrefType "journal-article" @default.
• W2404845416 hasAuthorship W2404845416A5003058999 @default.
• W2404845416 hasAuthorship W2404845416A5022210942 @default.
• W2404845416 hasAuthorship W2404845416A5046301560 @default.
• W2404845416 hasAuthorship W2404845416A5061465054 @default.
• W2404845416 hasAuthorship W2404845416A5064932633 @default.
• W2404845416 hasAuthorship W2404845416A5087980252 @default.
• W2404845416 hasConcept C162356407 @default.
• W2404845416 hasConcept C169760540 @default.
• W2404845416 hasConcept C170493617 @default.
• W2404845416 hasConcept C181199279 @default.
• W2404845416 hasConcept C185592680 @default.
• W2404845416 hasConcept C192989942 @default.
• W2404845416 hasConcept C2776706248 @default.
• W2404845416 hasConcept C2776710720 @default.
• W2404845416 hasConcept C2776885963 @default.
• W2404845416 hasConcept C2777477808 @default.
• W2404845416 hasConcept C2777503454 @default.
• W2404845416 hasConcept C2780539824 @default.
• W2404845416 hasConcept C31827203 @default.
• W2404845416 hasConcept C43617362 @default.
• W2404845416 hasConcept C513476851 @default.
• W2404845416 hasConcept C515207424 @default.
• W2404845416 hasConcept C538909803 @default.
• W2404845416 hasConcept C55493867 @default.
• W2404845416 hasConcept C62231903 @default.
• W2404845416 hasConcept C71240020 @default.
• W2404845416 hasConcept C86803240 @default.
• W2404845416 hasConceptScore W2404845416C162356407 @default.
• W2404845416 hasConceptScore W2404845416C169760540 @default.
• W2404845416 hasConceptScore W2404845416C170493617 @default.
• W2404845416 hasConceptScore W2404845416C181199279 @default.
• W2404845416 hasConceptScore W2404845416C185592680 @default.
• W2404845416 hasConceptScore W2404845416C192989942 @default.
• W2404845416 hasConceptScore W2404845416C2776706248 @default.
• W2404845416 hasConceptScore W2404845416C2776710720 @default.
• W2404845416 hasConceptScore W2404845416C2776885963 @default.
• W2404845416 hasConceptScore W2404845416C2777477808 @default.
• W2404845416 hasConceptScore W2404845416C2777503454 @default.
• W2404845416 hasConceptScore W2404845416C2780539824 @default.
• W2404845416 hasConceptScore W2404845416C31827203 @default.
• W2404845416 hasConceptScore W2404845416C43617362 @default.
• W2404845416 hasConceptScore W2404845416C513476851 @default.
• W2404845416 hasConceptScore W2404845416C515207424 @default.
• W2404845416 hasConceptScore W2404845416C538909803 @default.
• W2404845416 hasConceptScore W2404845416C55493867 @default.
• W2404845416 hasConceptScore W2404845416C62231903 @default.
• W2404845416 hasConceptScore W2404845416C71240020 @default.
• W2404845416 hasConceptScore W2404845416C86803240 @default.
• W2404845416 hasIssue "6" @default.
• W2404845416 hasLocation W24048454161 @default.
• W2404845416 hasOpenAccess W2404845416 @default.
• W2404845416 hasPrimaryLocation W24048454161 @default.
• W2404845416 hasRelatedWork W1499642052 @default.
• W2404845416 hasRelatedWork W2053460965 @default.
• W2404845416 hasRelatedWork W2074614182 @default.
• W2404845416 hasRelatedWork W2084590593 @default.
• W2404845416 hasRelatedWork W2153724285 @default.
• W2404845416 hasRelatedWork W2164283682 @default.
• W2404845416 hasRelatedWork W2343269492 @default.

• next